Volume 6, Number 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2000)                   Sci J Hamadan Univ Med Sci 2000, 6(4): 0-0 | Back to browse issues page


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Mohammad Alizadeh A H. A Case Report of Dublin-Johnson Syndrome. Sci J Hamadan Univ Med Sci . 2000; 6 (4)
URL: http://sjh.umsha.ac.ir/article-1-1014-en.html

Abstract:   (750 Views)

Hyperbilirubinemia is a common manifestation in internal medicine. It is divided to conjugated and unconjugated hyperbilirubinemia . Conjugated hyperbilirubinemia usually results from hepatocellular or cholestatic liver disease or from extrahepatic biliary obstruction. Isolated conjugated hyperbilirubinemia is the primary manifestation of two heritable disorders, Rotor and Dublin – Johnson syndromes, and can also be seen in some patients with the syndrome of recurrent benign intrahepatic cholestasis.

Dubin – Johnson syndrome is a rare, benign autosmally inheritd hyperbilirubinemia characterized by presence of dark pigment in the centrilobular regin of the liver cells.

Patients with Dubin – Johnson syndrome may be asymptomatic or have vague constitational or gasterointestinal syndromes. Pruritus is absent, and serum bile acid levels are normal.

     
Type of Study: Case Report | Subject: Special

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