Volume 5, Number 2 (Scientific Journal of Hamadan University of Medical Sciences-Spring & Summer 1998)                   Sci J Hamadan Univ Med Sci 1998, 5(2): 0-0 | Back to browse issues page


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Kheirollah A, Zahraei M. The Study of Alterations of alpha – 1 – Antitrypsin (1-AT) in Serum of Hypothyroid Patients. Sci J Hamadan Univ Med Sci . 1998; 5 (2)
URL: http://sjh.umsha.ac.ir/article-1-1040-en.html

Abstract:   (531 Views)

Alpha-1- Protease inhibitor or a1-Antitrypsin (a1-AT) is an a1-glycoprotein and a small molecule which acts as an extracellular inhibitor of serin proteases. It seems that this molecule protein has a protective role in tissues such as inhibition (inactivation) of elastase, colagenase, etc.

a1-AT deficiency is a hereditary disorder which characteristed by reduced
a1-AT serum level and may cause emphysema, skin disorders, etc.

This study measures alteration of this 27 hypothyroid patients and 30 healthy individuals.

T3,T4, TSH was assayed by g-counter and TIC (trypsin inhibitory capacity) by sysnthetic substrate BAEE and using U.V. spectrophotometer.

The results showed the TIC in hypothyroid patients was significantly lower than that of healthy individual (1.28U+ 0.148 Vs 1.87 + 0.29 mg/ml).

Sina correlation between T3 and TIC for hypothyroid was 0.62, then it should be concluded that trypsin inhibitory capacity and a1-AT concentrration decreased in hypothyroidism and decrease dinsity of dermal elastic fiber.

     
Type of Study: Original | Subject: Special

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