Volume 3, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Autumn & Winter 1996)                   Sci J Hamadan Univ Med Sci 1996, 3(1): 0-0 | Back to browse issues page


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Manighalam S, Toosi P, Tahriri S. The Study of Results of Liver Biopsy in Psoriatic Patients Which Treated by Methotrexate. Sci J Hamadan Univ Med Sci . 1996; 3 (1)
URL: http://sjh.umsha.ac.ir/article-1-1074-en.html

Abstract:   (552 Views)

Objective: To assess Methotrexate-related side effects on the liver.

Patients & methods: 45 liver biopsies were examined in dermatology ward of Loghman-e-Hakim Hospital in 1986-91.27 liver biopsies were examined after treatment with Methotrexate and were comparisoned with 27 liver biopsies which were not treated with Methotrexate.

Results: Among 27 liver biopsies which were treated with Methotrexate, 50% mild fatty degeneration 20% mild fibrosis, 11% severe fibrosis and 4% Cirrhosis.

Conclusion: Methotrexate has little side effects on liver and the most common Methotrexate-related side effects are fatty degeneration and fibrosis.

     
Type of Study: Original | Subject: Special

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