Volume 19, Number 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2013)                   Sci J Hamadan Univ Med Sci 2013, 19(4): 11-19 | Back to browse issues page


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Amiri I, Rabiee S, Goodarzi M T, Etemadi K, Hematpour Z. Assessment of Correlation between Homocysteine Concentration in Follicular Fluid and Oocyte and Embryo Quality in Polycystic Ovary Syndrome Patients Undergoing Assisted Reproductive Technology. Sci J Hamadan Univ Med Sci . 2013; 19 (4) :11-19
URL: http://sjh.umsha.ac.ir/article-1-159-en.html

Associate Professor of Anatomy, Research Center for Endometr & Endometriosis, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran. , amiri@umsha.ac.ir
Abstract:   (1023 Views)

Introduction & Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. According to the Rotterdam criteria, this syndrome is identified by presence of two of three criteria: (1) polycystic ovaries (2) oligo/anovulation and/or (3) clinical or biochemical evidence of hyperandrogenism. Low mature oocyte and embryo have been reported in polycystic ovary syndrome patients undergoing assisted reproduction. An inverse correlation between follicular fluid homocysteine (Hcy) concentration and oocyte and embryo maturity has also been found. This study has been implemented to do more evaluation on the relationship between homocysteine levels in follicular fluid and oocyte and embryo quality.

Materials & Methods: 30 PCOS patients as case group and 30 women with male factor infertility as control group were included in the study. The follicular fluid in the cases was collected during ovary punition and Hcy level was measured by ELISA method. The oocytes and embryos were classified into several groups. The Hcy levels of follicular fluid of two groups were compared and its relation with oocyte and embryo quality was assessed.

Results: Although the homocysteine concentration in follicular fluid of the case group was higher than the control group, the differences were not statistically significant. Moreover , no significant correlation was found between oocyte and embryo quality and homocysteine concentration of follicular fluid of the two groups.

Conclusion: In our study, no significant correlation was found between oocyte and embryo quality and homocysteine concentration of follicular fluid of PCOS patients but further stud-ies with larger sample sizes are recommended.

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Type of Study: Original | Subject: Special

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