Volume 19, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Spring 2012)                   Sci J Hamadan Univ Med Sci 2012, 19(1): 27-31 | Back to browse issues page


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Karami P, Aslani M M, Najafi Mosleh M, Alikhani M Y. Determination Pattern of Antibiotic Resistance in Entropathogenic Escherichia coli Strains Isolated from Children with Diarrhea. Sci J Hamadan Univ Med Sci . 2012; 19 (1) :27-31
URL: http://sjh.umsha.ac.ir/article-1-198-en.html

, alikhani@umsha.ac.ir
Abstract:   (926 Views)

Introduction & Objective: Diarrheal diseases are considered a major health problem, especially in children. Enteropathogenic Escherichia coli (EPEC) strains are the common cause of diarrhea in children especially in developing countries. Because of undesirable effects of diarrhea and its interference with children's growth, in some cases antibiotic treatment is recommended. In recent years, resistance toward common and effective antibiotics in the treatment of infectious diseases became one of the most important challenges in medical society, for this purpose, antibiotic sensitivity and resistance of strains in every geographical zone must be determined. So in this study, of antibiotic patterns of these bacteria were examined.

Materials & Methods: This cross-sectional study was performed on 192 strains of Enteropathogen Escherichia coli isolated from children who were suffering from diarrhea in 1389-1390 in the microbiology laboratory of Hamadan University of medical sciences. To identify these strains, standard biochemical and serology tests were used. The antibiotic sensitivity test of these isolates was carried out with disc diffusion agar method according to the CLSI standards for 14 different antibiotics disc. Resistance toward 3 or more than 3 classes of antibiotics were defined as multidrug resistance.

Results: The result of this study shows EPEC strains had the highest resistance to cefpodoxime (97%), trimethoprim (60.7%), tetracycline (58.4%) and ampicillin (45.8%). Multidrug resistance was 68.7 percent. These strains also showed the highest sensitivity against imipenem, ceftriaxone, and ciprofloxacin antibiotics.

Conclusion: EPEC strains that were studied with resistance to ampicillin, tetracycline and convenient sensitivity against fluoroquinolones are one of the major factors in children’s diarrhea. A result of this research suggests that antimicrobial resistance in Escherichia coli strains are high and prescribing and antibiotic is not logical, because it makes the treatment of infectious diseases difficult. So with supervision on the consumption of antimicrobial agents in the treatment of multidrug resistant infections and if possible, with determining resistant strains of phenotypes and genotypes, the development of resistance in bacteria can be prevented.

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Type of Study: Original | Subject: Special

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