Volume 29, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2023)                   Avicenna J Clin Med 2023, 29(4): 204-210 | Back to browse issues page

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Salim Bahrami S A R, Khamse M, Sanaei Z, Karkhanei B. Relationship of Oxygen Saturation Percentage (SaO2) and Arterial Oxygen Pressure (PaO2) with the Outcome of Covid-19 Patients Hospitalized in intensive care Units. Avicenna J Clin Med 2023; 29 (4) :204-210
URL: http://sjh.umsha.ac.ir/article-1-2574-en.html
Relationship of Oxygen Saturation Percentage (SaO2) and Arterial Oxygen Pressure (PaO2) with the Outcome of Covid-19 Patients Hospitalized in intensive care Units
Seyed Ahmad Raza Salim Bahrami1 , Mona Khamse2 , Zahra Sanaei3 , Behrouz Karkhanei 4
1- Department of Anesthesia, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Anesthesia, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , bk13472000@yahoo.com
Abstract:   (1220 Views)

Background and Objective: In order to determine the Hypoxemia and prognosis of patients with covid-19 hospitalized in the intensive care unit, reliable oxygen supply indicators are needed. In this situation, the examination of the percentage of arterial oxygen saturation (SaO2) and arterial oxygen pressure (PaO2), as well as their relationship, may be helpful.

Materials and Methods: This descriptive-cross-sectional study examined 1,121 patients with covid-19 hospitalized in the intensive care unit of hospitals affiliated with Hamadan University of Medical Sciences. Data were collected through a researcher-made checklist, including age, gender, history of smoking and drug use, underlying disease, duration of hospitalization, the outcome of hospitalization, and hemoglobin listed in the patient's medical records. Moreover, SaO2 and PaO2 were examined in the first arterial blood analysis report after admission to the hospital.

Results: A positive and significant correlation was observed between SaO2 and PaO2 (r=0.733 and P<0.001). SaO2 significantly predicted Pao2 in COVID-19 patients (β=63.51, R2=0.630, P<0.001). Furthermore, the duration of hospitalization had a positive and significant correlation with PaO2 (r=0.112, P<0.001) and SaO2 (r=0.063, P=0.034).
Conclusion: The measurement of the percentage of oxygen saturation and arterial oxygen pressure through arterial blood gas analysis is more accurate in diagnosing Hypoxemia in covid-19 patients. They are better indicators to determine the prognosis of critically ill patients.

 
Keywords: Blood Gas Analysis, COVID-19, Hypoxemia
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Type of Study: Original | Subject: Infectious Diseases
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References
1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. PMID: 32091533 DOI: 10.1001/jama.2020.2648
2. Sayan I, Altınay M, Çınar AS, Türk HŞ, Peker N, Şahin K, et al. Impact of HFNC application on mortality and intensive care length of stay in acute respiratory failure secondary to COVID-19 pneumonia. Heart Lung. 2021; 50(3):425-9. PMID: 33621840 DOI: 10.1016/j.hrtlng.2021.02.009
3. Hicks T, Winter A, Green K, Kierkegaard P, Price DA, Body R, et al. Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation. BMC Health Serv Res. 2021;21(1):532. PMID: 34059036 DOI: 10.1186/s12913-021-06460-x
4. Bartoletti M, Azap O, Barac A, Bussini L, Ergonul O, Krause R, et al. ESCMID COVID-19 living guidelines: drug treatment and clinical management. Clin Microbiol Infect. 2022;28(2):222-38. PMID: 34823008 DOI: 10.1016/j.cmi.2021.11.007
5. Badraoui R, Alrashedi MM, El-May MV, Bardakci F. Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19. J Biomol Struct Dyn. 2021;39(17):6842-51. PMID: 32752936 DOI: 10.1080/07391102. 2020.1803139
6. Mina B, Newton A, Hadda V. Noninvasive ventilation in treatment of respiratory failure-related COVID-19 infection: review of the literature. Can Respir J. 2022;2022:9914081. PMID: 36091330 DOI: 10.1155/2022/9914081
7. Bilan N, Dastranji A, Behbahani AG. Comparison of the spo2/fio2 ratio and the pao2/fio2 ratio in patients with acute lung injury or acute respiratory distress syndrome. J Cardiovasc Thorac Res. 2015;7(1):28-31. PMID: 25859313 DOI: 10.15171/jcvtr.2014.06
8. Yaghoubi N, Youssefi M, Jabbari Azad F, Farzad F, Yavari Z, Zahedi Avval F. Total antioxidant capacity as a marker of severity of COVID‐19 infection: Possible prognostic and therapeutic clinical application. J Med Virol. 2022;94(4):1558-65. PMID: 34862613 DOI: 10.1002/jmv.27500
9. Holmes K, Kazmierczak K, Irwin KE, Evans CC. Is prone positioning effective in improving hypoxemia for nonventilated patients with COVID-19? A rapid evidence assessment. Cardiopulm Phys Ther J. 2022;33(1):40-8.
10. James A, Petit M, Biancale F, Bougle A, Degos V, Monsel A, et al. Agreement between pulse oximetry and arterial oxygen saturation measurement in critical care patients during COVID-19: a cross-sectional study. J Clin Monit Comput. 2023:1-8. DOI: 10.1007/s10877-022-00959-2
11. Wilson‐Baig N, McDonnell T, Bentley A. Discrepancy between SpO2 and SaO2 in patients with COVID‐19. Anaesthesia. 2021;76(Suppl 3) :6-7. PMID: 32738055 DOI: 10.1111/anae.15228
12. Turcato G, Panebianco L, Zaboli A, Scheurer C, Ausserhofer D, Wieser A, et al. Correlation between arterial blood gas and CT volumetry in patients with SARS-CoV-2 in the emergency department. Int J Infect Dis. 2020;97:233-5. PMID: 32553834 DOI: 10.1016/j.ijid.2020.06.033
13. Bezuidenhout MC, Wiese OJ, Moodley D, Maasdorp E, Davids MR, Koegenlenberg CF, et al. Correlating arterial blood gas, acid-base and blood pressure abnormalities with outcomes in COVID-19 intensive care patients. Ann Clin Biochem. 2021;58(2):95-101. PMID: 33103442 DOI: 10.1177/0004563220972539
14. Oliynyk OV, Rorat M, Barg W. Oxygen metabolism markers as predictors of mortality in severe COVID-19. Int J Infect Dis. 2021;103:452-6. PMID: 33310024 DOI: 10.1016/j.ijid.2020.12.012
15. Farkhad NK, Reihani H, Moghadam AA, Moghadam AB, Tavakol-Afshari J. Are mesenchymal stem cells able to manage cytokine storm in COVID-19 patients? A review of recent studies. Regen Ther. 2021;18:152-60. PMID: 34124322 DOI: 10.1016/j.reth.2021.05.007
16. Sirohiya P, Vig S, Pandey K, Meena JK, Singh R, Ratre BK, et al. A correlation analysis of peripheral oxygen saturation and arterial oxygen saturation among COVID-19 patients. Cureus. 2022;14(4):24005. PMID: 35547430 DOI: 10.7759/cureus.24005
17. Kumar A, Aggarwal R, Khanna P, Kumar R, Singh AK, Soni KD, et al. Correlation of the SpO2/FiO2 (S/F) ratio and the PaO2/FiO2 (P/F) ratio in patients with COVID-19 pneumonia. Med Intensiva. 2022;46(7):408-10. PMID: 34812212 DOI: 10.1016/j.medin.2021.10.005
18. Roozeman JP, Mazzinari G, Serpa Neto A, Hollmann MW, Paulus F, Schultz MJ, et al. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study. J Crit Care. 2022;68:31-7. PMID: 34872014 DOI: 10.1016/j.jcrc.2021.11.009
19. Nguyen LS, Helias M, Raia L, Nicolas E, Jaubert P, Benghanem S, et al. Impact of COVID-19 on the association between pulse oximetry and arterial oxygenation in patients with acute respiratory distress syndrome. Sci Rep. 2022;12(1):1462. DOI: 10.1038/s41598-021-02634-z
20. Damiani E, Carsetti A, Casarotta E, Scorcella C, Domizi R, Adrario E, et al. Microvascular alterations in patients with SARS-COV-2 severe pneumonia. Ann Intensive Care. 2020;10(1):60. PMID: 32436075 DOI: 10.1186/s13613-020-00680-w
21. Luks AM, Swenson ER. Pulse oximetry for monitoring patients with COVID-19 at home. potential pitfalls and practical guidance. Ann Am Thorac Soc. 2020;17(9):1040-6. PMID: 32521167 DOI: 10.1513/AnnalsATS.202005-418FR
22. Bonaventura A, Mumoli N, Mazzone A, Colombo A, Evangelista I, Cerutti S, et al. Correlation of SpO(2)/FiO(2) and PaO(2)/FiO(2) in patients with symptomatic COVID-19: an observational, retrospective study. Intern Emerg Med. 2022;17(6):1769-75. PMID: 35460432 DOI: 10.1007/s11739-022-02981-3
23. Dormishian A, Schott A, Aguilar AC, Bancalari E, Claure N. Pulse oximetry reliability for detection of hypoxemia under motion in extremely premature infants. Pediatr Res. 2023;93(1):118-24. PMID: 35978093 DOI: 10.1038/s41390-022-02258-7
24. Brouqui P, Amrane S, Million M, Cortaredona S, Parola P, Lagier JC, et al. Asymptomatic hypoxia in COVID-19 is associated with poor outcome. Int J Infect Dis. 2021;102:233-8. PMID: 33130200 DOI: 10.1016/j.ijid.2020. 10.067
25. Kausar S, Rida-e-Zehra S, Latif A, Jafferi SA, Hussain SNF, Azim SN, et al. Prevalence of different severities of hypoxia in COVID-19 patients admitted in critical care unit. Int J Clin Med. 2020;8(2):62. DOI: 10.11648/j.ijacm.20200802.16
26. Guo L, Jin Z, Gan TJ, Wang E. Silent hypoxemia in patients with COVID-19 pneumonia: a review. Med Sci Monit. 2021;27:930776. PMID: 34635632 DOI: 10.12659/MSM.930776
27. Catoire P, Tellier E, de la Rivière C, Beauvieux MC, Valdenaire G, Galinski M, et al. Assessment of the SpO(2)/FiO(2) ratio as a tool for hypoxemia screening in the emergency department. Am J Emerg Med. 2021;44:116-20. PMID: 33588251 DOI: 10.1016/j.ajem.2021.01.092
28. Alamé K, Lemaitre EL, Abensur Vuillaume L, Noizet M, Gottwalles Y, Chouihed T, et al. Silent hypoxemia in the emergency department: a retrospective Cohort of two clinical phenotypes in critical COVID-19. J Clin Med. 2022;11(17):5034. PMID: 36078970 DOI: 10.3390/jcm11175034
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