Volume 30, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2023)
Avicenna J Clin Med 2023, 30(2): 65-71 |
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1- Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Modeling of Noncommunicable Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran ,mreza_sobhan@yahoo.com
2- Modeling of Noncommunicable Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (1374 Views)
Background and Objective: Considering the role of bacteria in causing some forms of acne, in recent years, the use of antibiotics along with other medications has had positive results in acne treatment; therefore, the present study aimed to compare the effect of the combination of topical erythromycin and zinc acetate with topical erythromycin alone in treating mild to moderate acne vulgaris.
Materials and Methods: In this clinical trial, 76 patients with acne vulgaris who were referred to a specialized skin clinic were selected and randomly assigned into two treatment groups, namely, A (n=39) and B (n=37). Group A was treated with a local solution of erythromycin 4% without zinc acetate, and group B was treated with a combined local solution of erythromycin 4% and zinc acetate 1.2%. The treatment continued twice a day for three months.
Results: In groups, A and B, respectively, the average lesion intensity score before treatment was 21.1 ± 6.5 and 21.9 ± 5.4 (P=0.555), the first month of treatment was 17.0 ± 6.4 and 15.7 ± 5.9 (P=0.578), the second month of treatment 9.1 ± 4.5 and 6.4 ± 3.3 (P=0.014), the third month of treatment 4.0 ± 3.0 and 2.0 ± 3.0 (P=0.001), and the frequency of complete recovery was 38.5 and 64.9%, respectively (P=0.021). In group B, the severity of papules in the second (P=0.002) and third (P=0.001) months of the treatment was significantly lower than in group A.
Conclusion: Based on the obtained results, using a combination of erythromycin 4% with zinc acetate 1.2% as a topical solution is more effective than the topical solution of erythromycin 4% alone in treating acne lesions
Materials and Methods: In this clinical trial, 76 patients with acne vulgaris who were referred to a specialized skin clinic were selected and randomly assigned into two treatment groups, namely, A (n=39) and B (n=37). Group A was treated with a local solution of erythromycin 4% without zinc acetate, and group B was treated with a combined local solution of erythromycin 4% and zinc acetate 1.2%. The treatment continued twice a day for three months.
Results: In groups, A and B, respectively, the average lesion intensity score before treatment was 21.1 ± 6.5 and 21.9 ± 5.4 (P=0.555), the first month of treatment was 17.0 ± 6.4 and 15.7 ± 5.9 (P=0.578), the second month of treatment 9.1 ± 4.5 and 6.4 ± 3.3 (P=0.014), the third month of treatment 4.0 ± 3.0 and 2.0 ± 3.0 (P=0.001), and the frequency of complete recovery was 38.5 and 64.9%, respectively (P=0.021). In group B, the severity of papules in the second (P=0.002) and third (P=0.001) months of the treatment was significantly lower than in group A.
Conclusion: Based on the obtained results, using a combination of erythromycin 4% with zinc acetate 1.2% as a topical solution is more effective than the topical solution of erythromycin 4% alone in treating acne lesions
Type of Study: Original |
Subject:
Dermatology
References
1. Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020;10(1):5754. PMID: 32238884 DOI: 10.1038/s41598-020-62715-3
2. Jaber RM, Alnshash BM, Mousa SN, Fayoumi HS, Al-Qaderi LM, Zant AM. The epidemiology of acne vulgaris among adolescents and young adults in Jordan University Hospital. Open J Nurs. 2020;10(4):353-66. DOI: 10.4236/ojn.2020.104024
3. Ogé LK, Broussard A, Marshall MD. Acne vulgaris: diagnosis and treatment. Am Fam Physcian. 2019;100(8):475-84. PMID: 31613567
4. Habeshian KA, Cohen BA. Current issues in the treatment of acne vulgaris. Pediatrics. 2020;145(2):225-30. PMID: 32358215 DOI: 10.1542/peds.2019-2056L
5. Eichenfield LF, Krakowski AC, Piggott C, Del Rosso J, Baldwin H, Friedlander SF, et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013;131(3):163-86. PMID: 23637225 DOI: 10.1542/peds.2013-0490B
6. Leung AK, Barankin B, Lam JM, Leong KF, Hon KL. Dermatology: how to manage acne vulgaris. Drugs Context. 2021;10:1-18. PMID: 34691199 DOI: 10.7573/dic.2021-8-6
7. Sevimli Dikicier B. Topical treatment of acne vulgaris: efficiency, side effects, and adherence rate. J Int Med Res. 2019;47(7):2987-92. PMID: 31122106 DOI: 10.1177/0300060519847367
8. Schachner L, Pestana A, Kittles C. A clinical trial comparing the safety and efficacy of a topical erythromycin-zinc formulation with a topical clindamycin formulation. J Am Acad Dermatol. 1990;22(3):489-95. PMID: 2138180 DOI: 10.1016/0190-9622(90)70069-t
9. Mohammadi S, Farajzadeh S, Pardakhti A, Khalili M, Mohebbi A, Yousefian MR, et al. A survey to compare the efficacy of niosomal erythromycin alone versus combination of erythromycin and zinc acetate in the treatment of acne vulgaris. J Kerman Univ Med Sci. 2017;24(5):420-30.
10. Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis. Dermatologic Ther. 2020;33(6):e14252. PMID: 32860489 DOI: 10.1111/dth.14252
11. Sayyafan MS, Ramzi M, Salmanpour R. Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild-to-moderate acne vulgaris. J Dermatological Treatment. 2020;31(7):730-3. PMID: 30998422 DOI: 10.1080/09546634.2019.1606394
12. Cervantes J, Eber AE, Perper M, Nascimento VM, Nouri K, Keri JE. The role of zinc in the treatment of acne: A review of the literature. Dermatol Ther. 2018;31(1):e12576. PMID: 29193602 DOI: 10.1111/dth.12576
13. Al-Hamamy HR, Sharquie KE, Noaimi AA, Hussein WN. Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris. Our Dermatol Online. 2014;5(4):347-351. DOI: 10.7241/ourd.20144.61
14. Capitanio B, Sinagra JL, Weller RB, Brown C, Berardesca E. Randomized controlled study of a cosmetic treatment for mild acne. Clin Exp Dermatol. 2012;37(4):346-9. PMID: 22369176 DOI: 10.1111/j.1365-2230.2011.04317.x
15. Rostami Mogaddam M, Safavi Ardabili N, Maleki N, Soflaee M. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. Biomed Res Int. 2014;2014:474108. PMID: 25157359 DOI: 10.1155/2014/474108
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