Volume 16, Number 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2009)                   Sci J Hamadan Univ Med Sci 2009, 16(3): 16-20 | Back to browse issues page


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Faghani M, Mohammad Ghasemi F, Nasiri E, Nikbakht M. Investigation of Intron 3 Polymorphism of p53 in Breast Cancer Patients in Isfahan. Sci J Hamadan Univ Med Sci . 2009; 16 (3) :16-20
URL: http://sjh.umsha.ac.ir/article-1-305-en.html

, mfaghani@gums.ac.ir
Abstract:   (985 Views)

Introduction & Objective: Genetic agents play important roles in developing of cancers. Mutations and polymorphism affects on p53 protein function in suppressing tumor. We aimed to investigate the intron 3 polymorphism of p53 in Isfahanian breast invasive ductal carcinoma.

Materials & Methods: We undertook a case–control study on 192 controls and 192 patients with breast invasive ductal carcinoma from Isfahan. p53 intron 3 genotypes were identified using allele-specific PCR. The c2-test was used to assess the statistical significance of the data.

Results: In control samples, the genotype distribution for p53 intron 3 polymorphisms was 57.3% and 42.7% for the A1/A2 and A1/A1 genotypes, respectively. In the cancer group, 85.4% of the cases were A1/A2 and 14.6% were A1/A1. The differences in the distribution of the p53 intron 3 polymorphism between the cases and controls were statistically significant (P<0.001).

Conclusion: Our findings indicated that p53 intron 3 polymorphism probably is a genetic predisposing factor for breast invasive ductal carcinoma development in Isfahanian specimens.

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Type of Study: Original | Subject: Special

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