Volume 14, Issue 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2007)                   Avicenna J Clin Med 2007, 14(3): 29-35 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salehi I, Mohammadi M, Farajnia S, Gaderi Sophi F, Badalzadeh R, Vatankhah A M. Effect of Regular Swimming on Oxidative Stress and Atherogenic Index in Blood of Diabetic Male Rats. Avicenna J Clin Med. 2007; 14 (3) :29-35
URL: http://sjh.umsha.ac.ir/article-1-411-en.html
, IrSalehi@yahoo.com
Abstract:   (2508 Views)

Background & Objective: Diabetes is a metabolic disorder caused by low secretion or resistant to the insulin action. Oxidative stress, an imbalance between the free radical production and antioxidant defense systems of the body, is strongly related to diabetes and its symptoms. The aim of the present study is to evaluate effect of regular swimming on antioxidant system in diabetes.

Materials & Methods: Diabetes was induced by a single dose injection of streptozotocin (i.p, 50mg/Kg). Duration of exercise was 8 weeks. 40 male rats (200±20 g) were divided into four groups (control, control with exercise, diabetic, diabetic with exercise). At the end of experiments, rats were anesthetized by sodium pentobarbital (50mg/Kg) and blood samples were collected from the heart. Plasma and red blood cells were used to determine the super oxide dismutase (SOD), gluthathione peroxidase (GPX) and catalase (CAT) activities, and malonedialdehyde (MDA) levels.

Results: Diabetes significantly reduced SOD, GPX, and catalase activities in diabetic rats compared with control rats. MDA level, as a lipid peroxidation index, was increased significantly in diabetic-nonexercised rats compared to control. In response to exercise, MDA level decreased significantly in diabetic rats whereas SOD, GPX and catalase activities showed significant increases.

Conclusion: Swimming is beneficial in prevention of the hyperlipidemic symptoms and tissue injuries caused by oxidation stress in diabetes mellitus through increasing of the blood antioxidant enzyme activities, decreasing of the MDA level and reducing of the atherogenic index.

Full-Text [PDF 259 kb]   (840 Downloads)    
Type of Study: Original | Subject: Special

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2018 All Rights Reserved | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb