Volume 14, Issue 2 (Scientific Journal of Hamadan University of Medical Sciences-Summer 2007)                   Avicenna J Clin Med 2007, 14(2): 28-34 | Back to browse issues page

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Comparison of the Effect of Verapamil, Nifedipine and Diltiazem on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice. Avicenna J Clin Med. 2007; 14 (2) :28-34
URL: http://sjh.umsha.ac.ir/article-1-425-en.html
Abstract:   (1093 Views)

Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal seizure models (but not all animals). The aim of this study was to investigate the effects of verapamil, nifedipine and diltiazem on pentylenetetrazole-induced seizure threshold and to compare these effects in mice

Materials & Methods: In this experimental study, mice were pretreated intraperitoneally with vehicle or calcium channel blockers (0.5, 1, 2.5, 5, 10 and 20 mg/kg) before intravenously the determination of the pentylenetetrazole-induced seizure threshold.

Results: Our results showed that the pentylenetetrazole-induced seizure threshold was 33.4 0.42 mg/kg in control group. In animals pretreated with verapamil, nifedipine and diltiazem the pentylenetetrazole-induced seizure threshold dose dependently increased. Compare between calcium channel blockers showed that diltiazem and verapamil had greatest and least effects, respectively.

Conclusion: Our results suggest that the Ca2+ channel blockers possess anticonvulsant activity probably via an antagonism effect on voltage-gated Ca2+ channels.

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Type of Study: Original | Subject: Special

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