Volume 12, Number 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2006)                   Sci J Hamadan Univ Med Sci 2006, 12(4): 11-16 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mazdeh M, Monsef A R, Mani Kashani K. Study of Relationship between Homocysteine and Stroke. Sci J Hamadan Univ Med Sci . 2006; 12 (4) :11-16
URL: http://sjh.umsha.ac.ir/article-1-511-en.html

, mazdeh_m2007@yahoo.com
Abstract:   (808 Views)

Introduction & Objective : Stroke is the third most common cause of death in the world , and it is also a major cause of longterm disability . The most promising strategy to reduce the stroke is prevention and the success of this prevention strategy depends , however , on identifying and controlling all important causal and modifiable risk factors. A previously emerging risk factor for stroke , which is prevalent and modifiable and may be causal , is elevated plasma homocysteine. The author of this study hypothesized that elevated homocysteine (Hcys) is a risk factor for all of stroke subtypes in which atherosclerosis plays a primary role.

Materials & Methods : This case-controlled study included 58 patients (33 men and 25 women ) with stroke who were admitted to a university teaching hospital in Hamadan. The control group consisted of 103 randomly selected subjects (60 men and 53 women) with a mean age of 50 years who did not have a stroke. Both groups of patients provided a history of their vascular modifiable risk factors , effectiveness factor in plasma Hcys level . Then analyzed fasting blood samples , for plasma Hcys levels.

Results : Compared with control subjects , ischemic (n=44) , and hemorrhagic (n=14) strokes had higher geometric mean values of total Hcys and higher proportions of Hcys³ 11.0 mmol/L that was significant.

Conclusion: There is a significant association between elevated Hcys and all of stroke subtypes.

Full-Text [PDF 220 kb]   (365 Downloads)    
Type of Study: Original | Subject: Special

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Scientific Journal of Hamadan University of Medical Sciences

Designed & Developed by : Yektaweb