Volume 21, Number 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2015)                   Sci J Hamadan Univ Med Sci 2015, 21(4): 277-285 | Back to browse issues page


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Alamhulu M, Nazeri S. Investigation of Antibacterial and Antioxidant Activities of Alcoholic Extracts of Flower and Root of Dendrostellera Lesserti on Some Human Pathogenic Bacteria. Sci J Hamadan Univ Med Sci . 2015; 21 (4) :277-285
URL: http://sjh.umsha.ac.ir/article-1-65-en.html

Assistant Professor, Department of Biotechnology, School of Agriculture, Bu-Ali Sina University, Hamadan, Iran. , snblnazeri@yahoo.com
Abstract:   (919 Views)

Introduction & Objective: With increasing the information about the dangerous side effects of synthetic antibiotics , the demand for natural alternative of these drugs has increased. The purpose of this study is to investigate the antibacterial and antioxidant properties of root and flower extracts of the medicinal plant of Dendrostellera lesserti against some human pathogenic bacteria.

 Materials & Methods: In this experimental study, Dendrostellera lesserti was collected from Hamadan province in 2013. After identification, the extracts were prepared by maceration method. Antibacterial activities were determined by the agar well diffusion method, MIC (serial dilution method) and MBC. Antioxidant properties by DPPH method and amount of phenolic and flavonoid were measured by Folin-ciocalteu and aluminum chloride methods , respectively. The data were analyzed using sas software version 9.2 (P<0.05).

 Results: The largest growth inhibition zone with diameter of 21.33±.66 mm was seen in Salmonella typhi culture against root methanolic extract. MIC and MBC of root extract was lower in comparison with flower. Methanolic extract of flower in at concentration of 0.8 mg/ml had the highest scavenging percentage of free radical. The higher amount of phenol and flavonoid was related to methanol extract of root, 111.8±2.69 mgGAE/g and 2.25±0.35 mgQ/g, respectively

Conclusion: According to the obtained results, the root and flower methanolic extracts of Dendrostellera lesserti contain compounds with antibacterial and antioxidant properties.

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Type of Study: Original | Subject: Special

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