Lichen Planus is an inflammatory disorder of skin and mucous
membrane, with approximately unknown etiology and pathogenesis. From
the clinical aspect, the disease is characterized by polygonal, purple, itchy
and plan papules. Pathological changes are various in dermis and
epidermis. One of those, is necrotic Keratinocyte or Civatte Body that seen
in lower layer of epidermis and specially in upper layer of dermis.
This investigation was a three years study of clinical and histopathological
characteristics of Lichen Planus and relationship between response of
Civatte body (Civ-b) and activity of the disease, in Sina hospital of
Hamadan city (1995-98). This study was an analytic cross sectional study,
and was performed by 106 files and microscopic slides of the patients
affected by Lichen Planus.
In this study, results showed that 75.8% of all dermis Civatte Body are in
active phase of disease and this number is 88.2% for epidermis. The
correlation between number of Civatte body and disease activity was
statistically established by Fisher’s exact test (P value < 0.001). On the other
hand, disease activity was also related to intensity of band from infiltration.
Also results confirm that the more Civatte Body in dermis, the more
epidermis Civatte Body.
In this research, it was established that the more Civatte body, the more
activity of Linchen planus and the decrease of Civatte Body shows
decrease activity and relieve of disease.
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