Volume 23, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Spring 2016)                   Sci J Hamadan Univ Med Sci 2016, 23(1): 88-92 | Back to browse issues page


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Safari M, Baghbani A. A Case Report of a Patient with Leukocyte Adhesion Deficiency Type I Syndrome and Normal Time of Umbilical Cord Detachment. Sci J Hamadan Univ Med Sci . 2016; 23 (1) :88-92
URL: http://sjh.umsha.ac.ir/article-1-865-en.html

Assistant Professor of Pediatrics, Research Center for Molecular Medicine Hamadan University of Medical Sciences & Health Services, Hamadan, Iran. (mo_sfr@yahoo.com)
Abstract:   (833 Views)

Introduction: Leukocyte adhesion deficiency type 1 is a rare disorder of function of neutrophils which presents with recurrent bacterial and fungal infections. The patients usually have a history of delayed umbilical cord detachment.

Case Report: The patient was a fourteen-month-old boy with recurrent bronchopneumonia, skin abscess and oral candidiasis. There was a history of abscess formation in site of vaccine injection in two and four months of age. The umbilical cord detachment was occurred in the 6th day of birth. Laboratory studies showed marked leukocytosis and neutrophilia .Flowcytometry showed low amount of CD18. These were all compatible with a diagnosis of leukocyte adhesion deficiency type I (LADs1).

Conclusions: The patients die in the event of a delay in diagnosis because of recurrent severe infections. Early diagnosis and treatment of these diseases by stem cell transplantation improve the survival of the patient.

(Sci J Hamadan Univ Med Sci 2016; 23 (1):88-92)

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Type of Study: Case Report | Subject: Special

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