Volume 6, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Autumn & Winter 1999)                   Sci J Hamadan Univ Med Sci 1999, 6(1): 0-0 | Back to browse issues page


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Jalali M, Golalipour J, Fazel A. Hypervitaminosis A Induced First Arch Syndrome. Sci J Hamadan Univ Med Sci . 1999; 6 (1)
URL: http://sjh.umsha.ac.ir/article-1-978-en.html

Abstract:   (645 Views)

In this study we examine the effect(s) of excess vitamin A on developing first branchial arch. Intraperitoneal administration of 10000 u/Kg of vitamin A at zero and 12 hrs, on day of gestation (vaginal plug = zero) induced high incidences of craniofacial defect such as mandibular hypoplasia and cleft palate. It is well known that distruption among the neural crest cells migration and/or differentiation during face formation might cause facial malformation. Based on our results, we may conclude that excess vitamin A probably interfere with crest cells migration in cranifacial as it may induced excess cell death. The later phenomena may also cause facial defects.

     
Type of Study: Original | Subject: Special

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