TY - JOUR T1 - Effect of Amlodipine on The Concentration of Carotid Tissue Endothelin in High Cholesterol Fed Rabbits TT - تأثیر آملودیپین بر غلظت بافتی اندوتلین درشریان کاروتید خرگوش های دریافت کننده رژیم غذایی با کلسترول بالا JF - umsha JO - umsha VL - 14 IS - 4 UR - http://sjh.umsha.ac.ir/article-1-400-en.html Y1 - 2008 SP - 43 EP - 48 KW - Amlodipine KW - Endothelin-1 KW - Atherosclerosis KW - Carotid Artery N2 - Introduction & Objective: Endothelin-1 is involved in induction and progression of atherosclerosis. Since several changes with abnormality in transferring of calcium ions have been seen in atherosclerotic vessels, it is supposed that calcium channel blockers can slowdown the process of atherosclerosis. Materials & Methods: This study was an interventional experiment. 36 Newsland white male rabbits were divided into four groups: control group receiving normal diet, a group receiving normal diet and amlodipine, a group with high-cholesterol diet and finally high-cholesterol diet with amlodipine group. Results: The levels of cholesterol and triglyceride in groups with high-cholesterol diet significantly increased compared to controls (p M3 ER -