%0 Journal Article %A Zarghami, Nosratollah %A Mohajri, Abbas %A Fakhrjoo, Ashraf %A Montazeri, Ali %A Asadi, Jahanbakhsh %T Study of Prostate Specific Antigen Gene Expression and Telomerase in Breast Cancer Patients: Relationship to Steroid Hormone Receptors %J Avicenna Journal of Clinical Medicine %V 14 %N 3 %U http://sjh.umsha.ac.ir/article-1-408-en.html %R %D 2007 %K Breast Cancer, Prostate Specific Antigen, Telomerase, %X Introduction & Objective: Breast cancer is the most common disease in women. In the expansion and progression of breast tumors combination of tumor markers including prostate specific antigen (PSA) and telomerase are engaged. The aim of this study was to evaluate relationship between telomerase activity and prostate specific antigen gene expression with steroid hormone receptors in breast cancer patients. Materials & Methods: This study was a case-control and consisted of 50 women diagnosed with breast benign tumors as control and 50 women having malignant tumors as cases. Telomerase activity was measured in tumor cytosol of samples by telomeric repeat amplification protocol (TRAP) assay. PSA protein was measured using ultra sensitive immunoflourometric assay and PSA mRNA expression was carried out using RT-PCR technique in all tumor tissues. Estrogen and progesterone receptors were stained using immunohistochemistry technique in tumor tissues. Data analysis was carried out by using SPSS software version 11.6 and paired t-student test. Results: Using TRAP assay, presence of the telomerase activity was positive in all of the breast cancer patients. The difference of relative telomerase activity (RTA) values between stages and also all grades were more statistically significant (p %> http://sjh.umsha.ac.ir/article-1-408-en.pdf %P 10-18 %& 10 %! Study of Prostate Specific Antigen Gene Expression and Telomerase in Breast Cancer Patients: Relationship to Steroid Hormone Receptors %9 Original %L A-10-2-369 %+ %G eng %@ 2588-722X %[ 2007