AU - Heshmatian, Behnam AU - Parviz, Mohsen AU - Karimian, Seyyed Morteza AU - Keshavarz, Mansour AU - Sohanaky, Hamid TI - Amygdala Centralis Cardiovascular Response to Renin Substrate Microinjection in Renovascular Hypertensive Rats PT - JOURNAL ARTICLE TA - umsha JN - umsha VO - 13 VI - 4 IP - 4 4099 - http://sjh.umsha.ac.ir/article-1-456-en.html 4100 - http://sjh.umsha.ac.ir/article-1-456-en.pdf SO - umsha 4 AB  - Introduction & Objectives: Previous studies have revealed that induction of two kidney-one clip (2K1C) Goldblatt hypertension in rats eliminates hypertensive response after inactivating of the Central Nucleus of the Amygdala (CA). The present study investigated the possibility of alteration in local Renin Angiotensin System (RAS) activity in CA after hypertension induction and evaluation of cardiovascular response to Renin Substrate (RS) microinjection into CA in Wistar rats. Materials & Methods: Clamps were placed on the left renal arteries to induce 2K1C Goldblatt hypertension. A similar surgery procedure without clipping was done in sham group. Rats were studied eight weeks after surgery. The Mean Arterial Blood Pressure (MAP) and heart rate (HR) were measured directly with indwelling arterial cannula under urethane anesthesia. Rats received bilateral cannulation of the CA for RS microinjection. After bilateral microinjection of consecutive doses of RS (0.5µL- 0.1, 1 & 10 µM) saline and pretreatment of losartan (10µM), saralasin(1nM) or captopril(10µM) before RS into CA, MAP and HR measured and compared between groups. Results: Bilateral microinjection of consecutive doses of RS   into CA increased MAP and HR significantly greater in hypertensive group in comparison with normotensive ones (P CP - IRAN IN - LG - eng PB - umsha PG - 20 PT - Original YR - 2007