AU - Zeraati, Fatemeh AU - Malakoti, Seyyed Mansour AU - Araghchian, Maliheh AU - Sheikh, Nasrin AU - Nadi, Ebrahim TI - Comparison of Inhibitory Effect of Gripe Mixture and Caraway Mixture on Acetylcholine Induced Spasm in Rat jejunum PT - JOURNAL ARTICLE TA - umsha JN - umsha VO - 10 VI - 3 IP - 3 4099 - http://sjh.umsha.ac.ir/article-1-657-en.html 4100 - http://sjh.umsha.ac.ir/article-1-657-en.pdf SO - umsha 3 ABĀ  - In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared. 2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1mml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test . The results show that both drugs inhibit the spasm induced by acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The caraway mixture showed a higher effect in comparison with gripe mixture (P<0.05). The caraway mixture has a higher inhibitory effect on acetylcholine induced spasm in rat jejunum . It seems that it has the same effect on human. CP - IRAN IN - LG - eng PB - umsha PG - 39 PT - Original YR - 2003