TY - JOUR T1 - A Rare Case Report of Kikuchi’s Disease or Histiocytic Necrotizing Lymphadenitis TT - گزارش یک مورد نادر بیماری کیکوچی یا لنفادنیت هیستیوسیتیک نکروزان JF - umsha JO - umsha VL - 10 IS - 3 UR - http://sjh.umsha.ac.ir/article-1-662-en.html Y1 - 2003 SP - 67 EP - 72 KW - Atypical Lymphocytosis KW - Histiocytic Necrotizing Lymphadenitis KW - Lymphadenopathy N2 - Kikuchi’s disease or histiocytic necrotizing lymphadenitis is uncommon disease that first time was recognized in Japan . The etiology of disease is unknown. Clinical features consist with unilateral cervical lymphadenopathy , often with upper respiratory prodrome and associated in some patients with fever . More cases occur in women , commonly under 40 years of age . The involved nodes are usually firm with rubbery , discrete and sometimes tender. Occasional patients present with generalized lymphadenopathy , and rarely, hepatosplenomegaly occurs. Diagnosis has been made by surgical biopsy & histological lymphnode appearance . The patient was a 27-years-old woman that was admitted in infectious ward of Sina Hospital in 2/1/2001 . The patient had fever since 10 days and about 40 days she had a mass in her left cervical that grew gradually. In physical examination of patient showed erythema of pharynx , no exuda and a mass in left cervical area that was, nontender , rubbery , discrete with size 5´5 cm . Her temperature was 39.6°c. Initial diagnosis were Typhoid fever or Infectious mononucleosis. Laboratory tests were relative leukopenia (4000/mm3) with 48% lymphocytosis & 35% Atypical lymphocyte. She was admitted in hospital in date of 1/2/2001 with complients of fever , headache and vomiting . For the patient was performed surgical biopsy with initial diagnosis of lymphoma by specialist surgen. Pathologist was reported kikuchi’s disease ( histiocytic necrotizing lymphadenitis). In the diagnositic approach to unilateral cervical lymphadenopathy and atypical lymphocytosis, kikuchi’s disease despite of the other more common cause as lymphoma, infectous mononucleosis should be considered . M3 ER -