%0 Journal Article %A Khodadadi, Iraj %A Zahraei, Mahin %T Measurement of Non-Enzymatic Glycosylated Serum Proteins (GSP) by Improved Thiobarbitoric Acid Assay %J Avicenna Journal of Clinical Medicine %V 6 %N 1 %U http://sjh.umsha.ac.ir/article-1-979-en.html %R %D 1999 %K Blood Glucose / Blood Proteins / Diabetes Mellitus / Glycosylation, %X Several classes of protein may undergo non-enzymetic addition of glucose derived product. Hemoglobin was the first protein shown to be modified. Subsequent studies have demonstrated a similar effect of glucose on lens crystalline, collagen, erythrocyte membrane proteins, albumin and other serum proteins. Measurement of these non-enzymatic glycosylated serum proteins (GSP) showed that the levels were approximately two to three times higher in diabetic than non-diabetic subjects. In diabetic patients the mean + SD of GSP was 0.693 + 0.257 (SD) nmol HMF per mg protein compared with 0.355 + 0.108 (SD) in controls (P< 0.001). in diabetic patients levels appear to reflect glycemia in the preceding several days and correlate with other parameters of diabetes such as FBS. In this study non-enzymaticaly glycosylated serum protein measured by a colorimetric assay in 96 diabetic and 37 control subjects and relationship of GSP to FBS was shown. %> http://sjh.umsha.ac.ir/article-1-979-en. %P 0-0 %& 0 %! %9 Original %L A-11-185-132 %+ %G eng %@ 2588-722X %[ 1999