TY - JOUR T1 - A Case Report of Dublin-Johnson Syndrome TT - معرفی یک مورد بیمار مبتلا به سندرم دوبین جانسون JF - umsha JO - umsha VL - 6 IS - 4 UR - http://sjh.umsha.ac.ir/article-1-1014-en.html Y1 - 2000 SP - 0 EP - 0 KW - Hyperbilirubinemia / Jaundice KW - Chronic Idiopathic N2 - Hyperbilirubinemia is a common manifestation in internal medicine. It is divided to conjugated and unconjugated hyperbilirubinemia . Conjugated hyperbilirubinemia usually results from hepatocellular or cholestatic liver disease or from extrahepatic biliary obstruction. Isolated conjugated hyperbilirubinemia is the primary manifestation of two heritable disorders, Rotor and Dublin – Johnson syndromes, and can also be seen in some patients with the syndrome of recurrent benign intrahepatic cholestasis. Dubin – Johnson syndrome is a rare, benign autosmally inheritd hyperbilirubinemia characterized by presence of dark pigment in the centrilobular regin of the liver cells. Patients with Dubin – Johnson syndrome may be asymptomatic or have vague constitational or gasterointestinal syndromes. Pruritus is absent, and serum bile acid levels are normal. M3 ER -