@article{ author = {Khoshhal, M. and Vafaei, F. and Sedigh, S. and Ghodrati, A.}, title = {Comparison of the Influence of Crown to Implant Ratio on Marginal Bone Loss around Implants in Posterior Areas of the Maxilla and Mandible}, abstract ={Introduction & Objective: Due to the patients’ growing interest in the use of dental implants, medical staff should be completely aware of treatment success and prognostic factors to prevent failures. The purpose of this study was to evaluate the effect of different crown to implant ratio (C / I Ratio) in the posterior areas of the maxilla and mandible as one of the most important principles of biomechanics on marginal bone loss around the implant neck (MBL). Material & Methods: This study was conducted as a prospective cohort study. In this study, patients treated at a private dental implants office during the years 2013-2014 were selected. Parallel digital radiographs 6 months and 12 months after loading the implants were measured to evaluate the effects of prosthetic implants on posterior areas of the maxillary and mandibular crowns by a digital caliper. All patients were evaluated radiographically and data were collected and analyzed by SPSS 16 with non parametrical tests. Results: A total of 48 fixtures of SIC Implant System in 18 patients, including 28 pcs in maxilla and 20 pcs in mandible were evaluated. Statistical analysis of marginal bone level around the implant neck in radiograpy taken showed no significant difference in the effect of different C/I Ratio of marginal bone loss around implants (P=0.094). Comparison of posterior areas of the maxilla and mandible also showed no difference between the effects of different amounts of C/I Ratio of the marginal bone. Conclusion: The present study showed that the marginal bone loss was not statistically significant after the placement of implants in the posterior region of the jaw with a different range of crown – to- implant ratio from 0.87 to 2.55. Thus, it seems that there is no relationship between marginal bone loss around the implant neck with different proportions of crown - implant and with the location of the treatment (P>0.05).  (Sci J Hamadan Univ Med Sci 2016; 23 (1):5-16)}, Keywords = {Crowns , Dental Implants , Marginal Bone}, volume = {23}, Number = {1}, pages = {5-16}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-850-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-850-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Nadi, F. and Dehghan, A. and Pourolajal, J. and Nadi, E.}, title = {The Histopathologic Pattern of Primary Pulmonary Malignant Tumor Incidence in Hamadan Province from 2005-2015}, abstract ={Introduction & Objective: Lung cancer is the most common cause of cancer death among the population of most countries in the world. In Hamadan as a region with significant population in Iran, the epidemiologic studies have not previously done. Therefore ,this study was carried out to evaluate the frequency of histopathological types of primary pulmonary malignant neoplasms in patients admitted to Hamadan educational hospitals from 2005 to 2015. Materials & Methods: This research is a cross sectional study. In this study, 263 cases(225 males and 38 females) out of 429 pathology samples reported to be lung cancers  were entered into the study. These data were collected at Be’asat, Shahid Beheshti and Razi pathology laboratory centers. The data were analyzed by STATA software, c2, t test and ANOVA. Results: The results show that in Hamadan contrary to the world statistics, 44.87% of patients had squamous cell carcinoma, 25,1%had small cell lung cancer, 14.8% had adenocarcinoma and 15.2% had other types of carcinoma. 85.5% of the samples  were related to  males and 14.45% related to females. Conclusion: This study shows that during 10 years in Hamadan province in opposite of universal studies bronchogenic lung cancer tumor was squamous cell carcinoma. Moreover ,tumors incidence in males are more than women.  (Sci J Hamadan Univ Med Sci 2016; 23 (1):17-24)}, Keywords = {Carcinoma Squamous Cell , Histopathology , Lung Neoplasms}, volume = {23}, Number = {1}, pages = {17-24}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-852-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-852-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Farokhneshat, F. and Rahmani, A.R. and Samadi, M.T and Soltanian, A.R.}, title = {Non-Carcinogenic Risk Assessment of Heavy Metal of Lead, Chro-mium and Zinc in Drinking Water Supplies of Hamadan in Winter 2015}, abstract ={Introduction & Objective: Heavy metals are the most harmful contaminants found in drinking water supplies that can lead to serious damage to metabolic, physiological and body structures. Industrial activities like production and storage of sewage spills and improper disposal of industrial wastes as well as the exhaustion of the distribution network and the home network can cause the release of heavy metals in the drinking water. Therefore, the  measurement of these elements at the point of use is necessary. Material & Methods: This cross-sectional study assessed the amount of lead,chromium, and zinc in the drinking water of Hamadan City  in the winter of 1393 which can increase the risk of getting non-cancer diseases Stratified random sampling was conducted to measure the samples concentration by atomic absorption (Perkin Elmer, AAS-PEA-700 model). In order to carry out the risk characterization and sectional exposure assessment, the US EPA (Environmental Protection Agency of America) were used. Results: The results showed that the average concentration of lead, chromium and zinc at the point of use of surface water resources, 10.927, 2.246 and 1305.604 the underground 19.301, 11.085 and 1613.709and mixed 20.085, 11.563 and 1299.844 , respectively and the average of exposure to risk  of children is 0.078 and  of adults are 0.047and lead risk index was HQ<1 for all ages. Zinc and chromium had 31.7 percent risk for < 1month and 1-3 month age group and exposure to zinc and chromium, higher than the 0.3, have been 0.003, respectively. Conclusion: 41.46 percent of the samples contained Lead concentration higher than WHO standards and Industrial Research of Iran Institute of Standards and 39.02 percent of the samples had concentrations above the EPA standard. None of the samples  had sectional risk for children and adults. Although the amount of chromium and zinc was sub-standard, because they are  highly disease producing, the risk in the two  following age groups increases  :  < 1month and 1-3 months. Therefore, sub-standard concentration does not mean that there is no risk. (Sci J Hamadan Univ Med Sci 2016; 23 (1):25-33)}, Keywords = {Atomic Absorption , Heavy Metals , Water}, volume = {23}, Number = {1}, pages = {25-33}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-853-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-853-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Eshghi, Gh. and Alirezaei, P. and Ghalavand, H. and Khezrian, L.}, title = {Comparison of Serum Lipid Levels in Skin Tag Affected Patients with Healthy Individuals}, abstract ={Introduction & Objective: Skin tag is a soft, small and pedunculated lesion that is usually located on the skin folds like neck and axilla. The relationship between skin tags and dyslipidemia has been reported in several studies. This study was conducted with the aim of comparing serum lipid levels in skin tag affected subjects with healthy individuals. Materials & Methods: In this case-control study, lipid profile (serum levels of total cholesterol, triglyceride, low density lipoprotein (LDL) and  high density lipoprotein (HDL)) of skin tag affected patients presenting to dermatology clinic of Farshchian hospital (Hamadan, Iran) was compared with lipid profile of individuals presenting to the same clinic for the reasons other than skin tags. All the data collected were analyzed with SPSS16 software. Results:  In this study, lipid profile of 49 skin tag affected individuals was compared with lipid profile of 49 individuals not affected by such lesion. Mean serum levels of total cholesterol, triglyceride, LDL and HDL were significantly higher in the affected group in comparison to control group (P<0.05). Conclusions: This study showed that the presence of skin tags could be related to increased levels of serum lipids. It is recommended that physicians consider the possibility of dyslipidemia in patients presenting with these skin lesions. (Sci J Hamadan Univ Med Sci 2016; 23 (1):34-39)}, Keywords = {Dyslipidemia , Lipid Profile , Skin Tags }, volume = {23}, Number = {1}, pages = {34-39}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-854-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-854-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Pahlevani, P. and Mosavi, S.M. and RastgooHaghi, A.R. and Lahotian, H. and EsnaAshari, F. and Alizadeh, Z.}, title = {Study of the Effects of Stachys Lvandulifolia Alcoholic Extract on Histomorphometry of Endometrium in Polycystic Ovarian Syndrome Rat Model}, abstract ={Introduction & Objective: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women. Chronic anovulation due to polycystic ovary syndrome predisposes women to endometrial changes.  Stachys lavandulifolia is an aromatic plant belonging to the Labiatae family proven to have estrogenic properties. In this study, we evaluated the effects of Stachys lavandulifolia extract on endometrial histological parameters in a rat model of PCOS. Materials & Methods: Thirty-six adult female Sprague-Dawley rats, weighing between 17-200 g were used in this experimental study. PCOS was induced by a single intramuscular injection of 4 mg Estradiol Valerate. The rats were divided into six groups; control group with no treatment, the PCOS group receiving solvent, three PCOS groups treated by multiple doses (225, 450, 900 mg/kg) of Stachys lvandulifolia extract, and PCOS group receiving clomiphene citrate (1.5 mg/kg). Extracts were injected intraperitoneally for a period of 4 estrous cycles (16 days). The endometrial biopsies were stained with Hematoxylin-Eosin and then the number of glands, endometrial glandular cell height, internal diameter of glands, height of epithelial cells and height of endometrium and pathological changes were examined. Results: The results showed that the height of surface epithelium and glandular epithelium increased and the endometrial thickness and internal diameter of glands insignificantly decreased in PCOS group compared to control (P>0.05) while the number of glands showed significant decrease (P=0.01). In addition, 40% of the rats in PCOS group showed endometrial hyperplasia. Treatment with clomiphen citrate and different concentrations of the Stachys lvandulifolia led height of glandular epithelium, internal diameter of glands, height of surface epithelium and endometrium and number of glands to become more similar to the control group, although they were not significant(P>0.05). Treatment with clomiphen citrate and 900 mg/kg concentrations of the Stachys lvandulifolia reduced hyperplasia in 35% and 33.3%  of rats respectively. Conclusion: The results of this study showed that stachys lvandulifolia dose dependently causes changes in the endometrial histological parameters of PCOS rat model.  (Sci J Hamadan Univ Med Sci 2016; 23 (1):40-48)}, Keywords = {Clomiphene , Endometrium , Estradiol , Polycyctic Ovary Syndrome, Stachys Lavandulifolia}, volume = {23}, Number = {1}, pages = {40-48}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-855-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-855-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Bidgoli, M. and Amiri, I. and Soheilifar, S. and Hoshyar, E.}, title = {In vitro Evaluation of the Effect of Melatonin on Osteogenic Differen-tiation of PDL Mesenchymal Stem Cells Isolated from Chronic Perio-dontitis Affected Teeth}, abstract ={Introduction & Objective: In recent years stem cells have been evaluated for regenerating lost tissues. Therefore, many studies aimed to assess isolation of these cells from different origins, and culture them. The purpose of this study is to evaluate the osteogenic differentiation of stem cells derived from periodontal ligament of periodontitis affected teeth in melatonin contained media. Materials & Methods: In this experimental-laboratory study after tooth extraction and isolating the apical segment of the roots, the periodontal ligament tissue was removed. Cells were expanded and after the third passage; flow cytometery analysis was performed to evaluate the surface markers (CD 105, CD146, CD90, CD 45, CD31, CD34, CD106 and CD 73). Adherent cell layer was used for osteogenic differentiation in melatonin contained osteogenic media. Then, osteogenic differentiation was evaluated using alizarin red staining, alkaline phosphatase and calcium content tests were performed. Results: Quantitative analysis of alizarin red staining on the 28th day demonstrated that mineralized nodule formation in the group supplemented with melatonin was higher than the control group. Results from alkaline phosphatase activity test on the 7th, 14th and 21st days demonstrated that, this activity was higher in the group supplemented with melatonin. Also, the amount of calcium on the 7th, 14th, 21st and 28th days, in melatonin group, was higher than the control group. Conclusion: Melatonin (50 µM) may be beneficial for differentiation of PDL stem cells into osteoblast.  (Sci J Hamadan Univ Med Sci 2016; 23 (1):49-56)}, Keywords = {Melatonin , Stem Cells , Osteogenesis}, volume = {23}, Number = {1}, pages = {49-56}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-860-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-860-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Pourmand, H. and Leili, M. and Shokouhi, R. and Asgari, Gh}, title = {The Assessment of Water Treatment Plant Sludge Properties and the Feasibility of Its Re-use according to Environmental Standards: Shahid Beheshti Water Treatment Plant Case Study, Hamadan}, abstract ={Introduction & Objectives: Water treatment leads to produce large volumes of sludges in water treatment plants which are considered as solid waste, and should be managed appropriately and logically to avoid bioenvironmental effects. Materials & Methods: In this cross-sectional study, the required samples were taken from the sludge of Shahid Beheshti water treatment plant to assay physical and chemical characteristics during one year from summer, autumn and winter 93 until spring 94. Sampling and testing procedures were full fit according to standard methods. Results: The average concentration of total solids parameters (TSS), total suspended solids (TSS), and total dissolved solids (TDS) were 22346, 21350 and 1005 mg/L, respectively. Among the heavy metals, aluminum, iron, manganese and zinc have the highest concentrations with the values of 1400, 956, 588 and 100 mg per kg of dry solids, respectively. The measured concentrations for cadmium were also higher than the permissible limits for agricultural purposes and discharges into the environment. The average concentrations of nickel were more than the recommended standard for industrial, agricultural and parkland application purposes. The concentrations were also slurry higher than the dry sludge. Conclusion: According to the past studies and results of this study, it could be concluded that contamination of heavy metals in sludge and slurry samples are more than dried sludge, .Therefore, if they are discharged into the environment, it is better to be disposed as dry sludges. Furthermore, because these types of waste sludges are routinely disposed in the environment, it is recommended to take the routine samples in order to measure the heavy metals and other relevant parameters contents of sludge before discharging it.  (Sci J Hamadan Univ Med Sci 2016; 23 (1):57-64)}, Keywords = {Heavy Metals , Sludge , Water Treatment }, volume = {23}, Number = {1}, pages = {57-64}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-861-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-861-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Aghelan, N. and SobhanArdakani, S.}, title = {Health Risk Assessment of Consumption of Tea marketed in Hamadan City, Potential Risk of As, Pb, Cd and Cr}, abstract ={Introduction & Objective: Tea is the most popular beverage in the world and contains several essential nutrients, which are beneficial for human health. Because the contamination of tea leaves by heavy metals may pose a serious threat to human, this study was carried out for analysis and health risk assessment of As, Pb, Cd and Cr in some black and green tea brand samples marketed in Hamadan City in 2015. Materials & Methods: After collection and preparation of  3 brands from each of cultivated and imported black and green tea specimens with acid digestion method in the laboratory, the concentrations of elements in samples were determined using Atomic Absorption Spectrophotometery in 3 replications. Also, all statistical analyses were performed using the SPSS statistical package. Results: The results showed that the maximum mean concentrations of As,Pb,Cd and Cr were as follows : As  0.34±0.54 µg kg-1 in imported green tea, Pb, Cd 577.0±608.0, 37.0±15.0 in domestic green tea respectively,  and Cr 165.0±114.0  iimported black tea samples, and significantly lower than WHO and ISIRI permissible limits. Conclusion: Although consumption of tea has not any adverse effects on the consumers’ health,  due to the increased use of agricultural inputs, sewage sludge and wastewater by farmers regular periodic monitoring of chemical pollutants content specially heavy metals in foodstuffs are recommended for food safety. (Sci J Hamadan Univ Med Sci 2016; 23 (1):65-74)}, Keywords = {Food Safety , Heavy Metals , Health Risk , Tea}, volume = {23}, Number = {1}, pages = {65-74}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-862-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-862-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Nazemi, M. and Moradi, Y. and Gozari, M. and Legzaee, F. and Karimpour, M.}, title = {Investigations of Antibacterial Activity of Methanol and Aqueous Ex-tracts of the Body Wall of Sea Cucumber Holothuria leucospilota on some Human Pathogenic Bacteria}, abstract ={Introduction & Objective: Holothuria leucospilota, sea cucumber, is a species of the Phylum Echinodermata. Sea cucumbers have the most natural products with biological activity. In this study we investigated the antibacterial activity of aqueous and methanol extract of H. leucospilota used against gram positive and gram negative human pathogenic bacteria. Materials & Methods: 9 Samples of H. leucospilota were harvested from the Hengam Island,. The methanol extract was prepared from the powder of sea cucumber. The antibacterial activity of the extracts was determined by broth dilution methods against clinical Gram-negative bacteria to identify MIC and MBC. Results: Aqueous extract of H. leucospilota was inactive on the bacteria. Methanol extract was active on Gram-negetive bacteria; E. coli, Salmonella typhi and Serratia marcescens. But it killed only Salmonella typhi and Serratia marcescens. The MBC of H. leucospilota methanol extract was 10 mg/ml. Methanol extract was active on all Gram-positive bacteria; B. pumilus, B. cereus and S. aureus but it killed only S. aureus. The MBC of H. leucospilota methanol extract was 40 mg/ml. Conclusion: Based  on our results,  H. leucospilota methanol extract. can be considered as a source of novel antibiotic. Contrary to many marine organisms, sea cucumbers are active against gram-negative bacteria.  (Sci J Hamadan Univ Med Sci 2016; 23 (1):75-82)}, Keywords = {Antibacterial , Cucumbers , Minimum Bactericidal Concentration, Minimum Inhibitory Cocentration}, volume = {23}, Number = {1}, pages = {75-82}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-863-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-863-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Eslami, F. and GhasemiBasir, H.R.}, title = {Evaluation of Etiologic Agents and Antibiotic Susceptibility of Patients with Corneal Ulcer}, abstract ={Introduction & Objective: Corneal ulcer is one of the most important medical emergencies that in the absence of on time diagnosis and treatment can lead to loss of vision. Therefore, identification of microorganisms and their response to drugs in each region is important. The aim of this study was to determine the most common organisms that cause keratitis and antibiotic sensitivity in this region. Materials & Methods: In this cross-sectional study, the effect of various factors such as age, sex, demographic properties, risk factors, culture results and antibiotic sensitivity of patients with corneal ulcer were studied in Farshchian Hospital. Results:  In this study, 80 patients with corneal ulcers were investigated. 46 cases with corneal ulcers had positive results (55.7%). 54% of culture-positives were men and 46% were female. Age distribution of outbreaks in two age ranges including under ten years and 50 to 69 years of age were more than others. Among the patients, trauma was the most important risk factor for corneal ulcer. Of the 80 evaluated corneal ulcers 57.5% of patients had positive corneal culture and 42.5% showed negative culture results. 84.4% out of 57.5% culture-positive samples had positive bacterial culture, and 15.6% had positive fungal cultures. The most common microorganism causing corneal ulcers was staph aureus with 36.8 percent among which Staph epidermidis (21.7%) is the most prevalent. The corneal ulcer causing microorganisms responded well to Ciprofloxacin therapy. Conclusions: The result of this study shows that culture and antibiogram of corneal ulcers are essential to determine the cause of ulcer and antibiotic susceptibility. Before obtaining culture results and antibiotic sensitivity, the most appropriate antibiotic must be selected as the empirical therapy based on the epidemiological conditions and the most common microorganism. (Sci J Hamadan Univ Med Sci 2016; 23 (1):83-87)}, Keywords = {Antibiotics Sensitivity , Corneal Ulcer , Risk Factors}, volume = {23}, Number = {1}, pages = {83-87}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-864-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-864-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Safari, M. and Baghbani, A.}, title = {A Case Report of a Patient with Leukocyte Adhesion Deficiency Type I Syndrome and Normal Time of Umbilical Cord Detachment}, abstract ={Introduction: Leukocyte adhesion deficiency type 1 is a rare disorder of function of neutrophils which presents with recurrent bacterial and fungal infections. The patients usually have a history of delayed umbilical cord detachment. Case Report: The patient was a fourteen-month-old boy with recurrent bronchopneumonia, skin abscess and oral candidiasis. There was a history of abscess formation in site of vaccine injection in two and four months of age. The umbilical cord detachment was occurred in the 6th day of birth. Laboratory studies showed marked leukocytosis and neutrophilia .Flowcytometry showed low amount of CD18. These were all compatible with a diagnosis of leukocyte adhesion deficiency type I (LADs1). Conclusions: The patients die in the event of a delay in diagnosis because of recurrent severe infections. Early diagnosis and treatment of these diseases by stem cell transplantation improve the survival of the patient. (Sci J Hamadan Univ Med Sci 2016; 23 (1):88-92)}, Keywords = {Infections , Leukocyte Adhesion Deficiency Syndrome , Umbilical Cord}, volume = {23}, Number = {1}, pages = {88-92}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-865-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-865-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Rezanezhad, A.A. and Alirezaei, P. and GhasemiBasir, H.R. and Sobhan, M.R. and Eshghi, Gh.}, title = {Cutaneous Horn-Like Papule on the Trunk: Warty Dyskeratoma on an Unusual Location}, abstract ={Introduction: Warty dyskeratoma (WD) is an uncommon and benign skin lesion that presents as a single papule or nodule with a keratin-filled center. This lesion is usually found on head and neck area, but has rarely been observed on other locations. Although WD may be clinically identical to many skin lesions, it has distinctive features in histopathologic examination that leads to correct diagnosis. Case Report: Herein we present a case of this rare skin lesion on lumbar area of a 75-year-old male. Conclusions:  Since WD is often located on head and neck area, the observation of such lesion on lumbar skin has clinical significance. (Sci J Hamadan Univ Med Sci 2016; 23 (1):93-96)}, Keywords = {Acantholysis , Dyskeratosis , Papule}, volume = {23}, Number = {1}, pages = {93-96}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-866-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-866-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Farshchian, N. and Razazian, N. and Rezaei, M. and Noorzadeh, A.}, title = {A Survey of Agreement Rate between Simple MTC and Post Contrast T1 Sequence MRI for Diagnosing Active Multiple Sclerosis Plaques}, abstract ={Introduction & Objective: MS is the most common disabling neurological disorder. Identifying  new active MS plaques at the onset and clinical status and faster onset of treatment as well as evaluating the response to treatment is important and MRI with contrast is the best indicator for these measures.     Materials & Methods: This study was cross-sectional including 62 patients with diagnosed MS. Whose clinical symptoms suggested the recurrence of MS. They were referred to the radiology department to undergo brain MRI  with injection for the diagnosis of active plaques by a neurologist,The Data were analyzed using statistical tests and SPSS 21 software. Results: Based on the sequences of post contrast T1, pre contrast MTC and post contrast MTC 74, 272 and 271 plaques were respectively discovered. Detection of active MS plaques on T1 sequences after injection were in poor accordance and had significant difference with MTC before and after injection. Moreover, detection of active MS plaques on MTC sequences before injection were in good accordance and did not show significant difference with MTC sequences after injection. Conclusion: Based on these results, it seems that the purpose of MRI in MS patients is determining the amount of active plaques. Sequences of pre contrast and post contrast MTC are significantly more than sequences of post contrast T1. Therefore, using sequences of MTC can be helpful in MRI.}, Keywords = {Enhanced-Contrast , Multiple Sclerosis , Magnetic Resonance Imaging, MTC Contrast }, volume = {23}, Number = {2}, pages = {97-102}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1169-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1169-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Shokri, H. and AmriSaroukolaei, Sh.}, title = {Evaluation of Vacuolar Aspartic Proteinase (VAP) Gene Expression in Candida albicans Strains Isolated from Systemic Candidiasis Patients}, abstract ={Introduction & Objective: Vacuolar proteinase is an aspartic enzyme in Candida albicans (C. albicans) that is expressed by VAP gene and plays an important role in the development of systemic candidiasis. The aim of this study was to evaluate VAP gene expression in C. albicans strains isolated from patients with systemic candidiasis. Materials & Methods: The evaluation of VAP gene expression was performed using reverse transcriptase-polymerase chain reaction (RT-PCR) method and samples were electrophoresed in 1.5% agarose gels. In addition, a total of 48 female Balb/c mice (six-weeks old and weight of 25 g) were experimentally infected by various C. albicans strains and the level of VAP gene expression was assessed in yeasts obtained from the blood of infected mice. Results: The level of VAP gene expression in non-Iranian strains was significantly higher than those of Iranian strains (P<0.05). Our results showed that VAP gene expression of C. albicans strains isolated from mice blood increased compared to human patients. A significant difference in the ratio of VAP to 18S rRNA genes was observed in both clinical and control strains of C. albicans isolated from non-Iranian patients compared to Iranian patients (P<0.05). The VAP and 18S rRNA bands were appeared after electrophoresis of the clinical strains of C. albicans obtained from human patients and mice blood that were about 220 and 302 bp, respectively. Conclusion: VAP gene as producer proteinase can act as an important gene in the development of systemic candidiasis caused by C. albicans.}, Keywords = {Candida Albicans , Systemic Candidiasis , VAP Gene}, volume = {23}, Number = {2}, pages = {103-109}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1170-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1170-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Tarbiat, M. and AghaeeMeybodi, S.A and Farhadian, M.}, title = {Comparing Alterations of Blood Glucose Level in type II Diabetic Pa-tients Taking Metformin and Withhold of Metformin on the Morning of Coronary Artery Bypass Graft Surgery}, abstract ={Introduction & Objective: In the context effect of metformin in patients with acute coronary syndrome, available evidence supports cardiac effect. Yet, there is doubt about continuation or discontinuation of metformin before major surgery. The aim of the present study is to determine the efficacy of continuing metformin in plasma glucose, renal function index, arterial PH in type II diabetic patients after coronary artery bypass graft surgery.     Materials & Methods: In this clinical-experimental study, 90 type II diabetic patients with ASA class II admitted for CABG surgery in Hamadan Ekbatan Hospital were enrolled  in the study in 2014 and were randomly assigned to two groups , one group treated with insulin and continued metformin and the other group treated with insulin and discontinued metformin.In the beginning indicators such as age, sex, body mass index (BMI) were compared which were not significantly different in the two groups. Then, other parameters such as blood glucose, BUN, Cr, arterial blood PH, cardiac arrhythmia and need for inotrope were compared. Used inotropes in this study included dopamine, dobutamine, epinephrine, norepinephrine, milrinon to achieve  systolic blood presser pressure over 100mmHg. Results: Average plasma BUN after surgery and one day after surgery in the group who discontinued metformin significantly were higher compared with the metformin group, but no differences were observed in average plasma BUN in  the 2nd and 3rd days after surgery in the two groups. During 3 days after surgery, average plasma creatinine was significantly lower in metformin group compared to non- metformin group. Although there was  no difference between the  two groups in pH parameter before surgery but in the metformin group, average pH was lower than non-metformin group after surgery. Before and 3 days after surgery mean blood glucose level was not significantly different between the two groups. During surgery, average need for inotrope in metformin group equaled 1.57 person and in non- metformin group equaled 1.05 person showing no significant difference in demography. In the both groups, not only before surgery, but also after surgery there was no cardiac arrhythmia. Also, the need for inotrope duration and tracheal intubation duration in ICU were not significantly different. Conclusion: Although serum glucose level of patients did not change, continuation and discontinuation of metformin in patients with CABG surgery was concomitant with elevated BUN and Cr. Level and decrease of pH on the 1st and 2nd days after surgery. Noticeably, BUN and Cr. Fluctuation in patients who continued metformin, were significantly lower, but  in the two groups these  values were  reversible and return to normal range in pending several days after surgery. Prescription of this drug did not increase the need for cardiac inotrope and risk of incidence of arrhythmia after surgery.}, Keywords = {Coronary Artery Baypass , Creatinin , Diabetes Mellitus , Metformin}, volume = {23}, Number = {2}, pages = {110-117}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1171-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1171-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Faghri, J. and Dehbanipour, R. and Mobasherizadeh, S. and Maleki, N.}, title = {Study of Antibiotic Resistance Pattern and Mutation in Genes gyrA and parC of Escherichia Coli Causing Urinary Tract Infection}, abstract ={Introduction & Objective: Fluoroquinolones are essential antimicrobial agents used to treat UTIs. Clinical experiences have shown a high rate of antibiotic resistance among uropathogens. These resistance are usually the consequence of mutations involving genes encoding gyrA and parC. The aim of this study was to determine antimicrobial resistance pattern and the presence of mutations in regions that code for quinolone resistance in the genes gyrA and parC in clinical isolates of E. coli from a hospital in Isfahan, Iran.     Materials & Methods: A total of 135 isolates of E.coli (from urine) were collected from September to February 2013 from Alzahra Hospital (Isfahan, Iran). Bacterial susceptibility to antimicrobial agents was determined using disk diffusion method. PCR was performed to detect genes gyrA and parC. Then, 13 isolates were randomly chosen for genetic characterization of the quinolone-determining region (QRDR) of the parC and gyrA genes. Results: Among 135 E. coli isolates, 61 isolates ( 45 % ) were resistant to fluoroquinolones. From 13 isolates, 11 isolates showed two mutations (Ser83Leu/ Asp87Asn) and 2 isolates showed a single mutation (Ser83Leu) in gyrA gene. Also, five different mutations were detected in parC gene in the E. coli isolates, encoding Ser80Ile, Ser80Val, Ser80Arg, Glu84Val, Gly78Ser. Conclusion: More research on the molecular basis of FQ resistance is required to develop new therapeutic strategies for FQ-resistant E. coli. To overcome antibiotic resistance antibiotic therapy should be limited and based on the susceptibility patterns of microorganisms.}, Keywords = {Esherichial coli , Fluorouinolone , Genes , Urinary Tract Infection }, volume = {23}, Number = {2}, pages = {118-125}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1172-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1172-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {KhajehJahromi, S. and Mohammadghasemi, F.}, title = {Effect of Various Doses of Nicotine on Mitotic Index in Esophageal Mucosa}, abstract ={Introduction & Objective: Nicotine could directly act as a cancer promoter. The purpose of this study was to evaluate effects of nicotine on mitotic index in esophagus epithelium. Materials & Methods: In the present study 30 adult male mice were used. Animals were randomly divided into three groups. Group A or the control group received vehicle, groups B and C received nicotine intraperitoneally at doses of 0.2 and 0.4 mg/kg once daily for 14 days, respectively. Evaluations were made using kI-67 immunohistochemistry and Hematoxilin& Eosin for proliferative activity and morphometric study on esophagus mucosa, respectively. Results: Administration of nicotine in group C, showed a significant increase (P<0.05) in KI-67 index 34.15±2.50vs. 10.41±1.4 compared with the control subjects.  The other parameters such as epithelial height, lamina propria, muscular mucosa and mucosa height in nicotine- treated groups were not affected. Nicotine at dose of 0.2 mg/kg did not change the mitotic index in epithelium when compared with the control group. Conclusion: This study indicates nicotine at dose of 0.4 mg/kg increases mitotic activity in basal cells in esophagus epithelium.}, Keywords = {Esophageal Mucosa , Morphometry , Nicotine , Proliferative Activity }, volume = {23}, Number = {2}, pages = {126-133}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1173-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1173-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Sedighi, F. and AbbasaliPourkabir, R. and Maghsood, A.H. and Fallah, M.}, title = {Comparison of Therapeutic Effect of Anti-Cryptosporidium Nano-Nitazoxanide (NTZ) with Free form of this Drug in Neonatal Rat}, abstract ={Introduction & Objective: Cryptosporidiosis caused by Cryptosporidium, which is a protozoan parasite, has a worldwide distribution. The infection is through fecal-oral route, direct or indirect contact, food or water. The treatment of cryptosporidiosis is difficult and the anti-parasitic agents are not effective. The purpose of this study was encapsulation of nitazoxanide in solid lipid nano-particles (SLN) and investigation of its anti-Cryptosporidium effect and its comparison with free drug in the neonatal rat.     Materials & Methods: Nitazoxanide was encapsulated by HPH method with 2 mg/Kg concentration in SLN nanoparticles. The oocysts were collected from calves and purified by sucrose floatation. A total of 72 Wistar neonatal rats were categorized in 6 groups of 12 rats including four infected groups treated by free drug, encapsulated nano drug, colloidal carriers without drug (SLN) and olive oil; an infected control group and a healthy control group that received PBS. 5 × 105 of oocyts inoculated orally into the sample groups. Finally, intestine of each rat was homogenized in PBS by rotor and the homogenized material was passed through a sieve. Then, floated oocysts in sucrose solution were counted by hemocytometer. Results: Treatment by nitazoxanide significantly decreased the number of parasites in the treatment groups. This decrease at day 6 was more than day 3. Nano nitazoxanide had more effects on parasites than free drug. This difference at day 3 of treatment was not significant (p= 0.182) but at day 6 was statistically significant (P< 0.001). Conclusion: Using nano-nitazoxanide could be a more effective way in the treatment of Cryptosporidium infections.}, Keywords = {Cryptosporidium , Nanomedicine , Nitazoxanide , Solid Lipid Nanoparticle }, volume = {23}, Number = {2}, pages = {134-140}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1174-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1174-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Keramat, F. and Rastegari, Sh. and Poorolajal, J. and Abdoli, E.}, title = {Comparison of Radiologic Findings among Smear-Positive and Smear- Negative Tuberculosis Patients}, abstract ={Introduction & Objective: The most common site of involvement in TB is the lungs. TB involves different parts of the lungs and has variable radiologic features. The aim of this study was to compare radiologic sequels between smear positive and smear negative pulmonary tuberculosis patients (PTPs). Materials & Methods: In an analytic cross-sectional study, 63 pulmonary tuberculosis patients who referred to Farshchian hospital and Health center in Hamadan from March 2012 to September 2014 were enrolled.  Demographic data, clinical manifestations of the patients (smear positive and smear negative), sputum smear results and imaging reports were gathered. In additional, clinical manifestations and radiological findings of the patients were evaluated at the end of the treatment. Thirty two patients remained until the end of the study. Results: Sixty three patients with mean age 56.85±24.20 were enrolled among that 68.25% of the patients were men and 31.75% were women. Forty four (69.84%) of the patients were smear positive and 19 (30.16%) of them were smear negative. Sputum was seen in smear positive patients more than smear negative patients. At the beginning of the treatment, the most common pulmonary involvements in imaging among the smear positive patients were reported to be nodular infiltration and fibrotic changes, but at the end of the treatment it was found to be atelectasis. However,in the smear negative patients the involvements were alveolar consolidation, nodular infiltration, pleural effusion, ground glass patterns and lymphadenopathy, and at the end of the treatment, fibrotic changes and reduction of pulmonary volume were seen. At the end of the treatment, 54.5% of smear negative patients and 85.7% of smear positive patients had abnormal imaging. Conclusion: At the end of the treatment, abnormal findings on diagnostic imaging were observed in both smear positive and negative patients (more than 50%). Knowledge of common and various imaging findings in smear positive and smear negative patients can be helpful for early diagnosis of pulmonary tuberculosis.}, Keywords = {Chest X-Ray , Radiologic Sequels , Pulmonary Tuberculosis , Smear}, volume = {23}, Number = {2}, pages = {141-148}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1175-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1175-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {ShokriRagheb, P. and SobhanArdakani, S.}, title = {Analysis of Co, Cr and Mn Concentrations in Atmospheric Dry Deposition in Hamadan City}, abstract ={Introduction & Objective: Heavy metals are major pollutants that can spread in the atmosphere with particulate matter and dust and because of the toxic and carcinogenic effects, their measurement and control is very important. Therefore, this study was conducted to assess Co, Cr and Mn concentration in the atmospheric dry deposition collected from Hamadan city in 2014.     Materials & Methods: After collection of 12 dust samples from 3 sampling stations and their laboratory preparation, metals concentrations were determined using ICP–OES. All statistical analyses were performed using the SPSS statistical package. Results: The results showed that the minimum and maximum mean concentrations of Co were 0.19 and 0.29 mg/kg for high and low traffic intensity sampling stations, respectively. The min and max mean concentrations of Cr were 0.65and 1.02 mg/kg for high traffic intensity and suburb sampling stations, respectively and the min and max mean concentrations of Mn were 7.23and 8.82 mg/kg for high and low traffic intensity sampling stations , respectively. Also comparing the mean concentrations of assessed metals with WHO permissible limits showed a significant difference (P< 0.05). The mean concentrations of metals were significantly lower than the maximum permissible limits. Conclusion: Although the mean concentrations of Co, Cr and Mn are  lower than the  standard levels, lack of continuous monitoring of heavy  metals concentrations in the dust and particulate matters in  the air  can lead to the entrance of various types of toxic pollutants such as heavy metals into the air and result in adverse health effects.}, Keywords = {Atmospheric Dry Deposition , Heavy Metals , Health Risk }, volume = {23}, Number = {2}, pages = {149-156}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1179-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1179-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {GhasemiBasir, H.R. and MosaviBahar, S.H.}, title = {A Survey of Epidemiologic Factors in Patients with Urinary Stones in Hamadan}, abstract ={Introduction & Objective: After urinary tract infection and prostatic disorders , the urine stones are the third common genitourinary diseases. Demographic, environmental and genetic factors affect urine stone formation. The aim of our study is to survey epidemiologic factors in patients with urinary stones referring to educational hospitals of Hamadan during 2010-2013.      Materials & Methods: In this analytic-cross-sectional study, we studied 500 cases of urinary stones referring to educational hospitals of Hamadan. The data were collected from electronic patient records system of laboratory. The results were registered in a check list and analyzed by spss16 and descriptive statistical indicators. Results: The patients were between 0.5-84 years. The average age of them was 40.36 years. In our study of 500 cases, 348 cases were male (69.6%) and 152 cases were female (30.4%). The male to female ratio was 2.3 to 1. Urinary stones were more prevalent   in 25- 45 year old men and 30-50 year old women. Among 500 patients, 466 cases had only one type of renal stones and 34 cases had 2 types. The calcium oxalate was the most common stone (386 cases, 72.5%). The other  common stone types were uric acid (130 cases, 24.3 %), cystine  (14 cases,2.6 %) ,calcium carbonate (3 cases,0.5 %)  and  calcium phosphate (1 case,0.1 %) Conclusion: Urinary stones are twice as common in men as in women. Most patients are between 38-42 years old. The most common stone in both sexes and all ages was calcium oxalate.}, Keywords = {Calcium Oxalate Stone , Cystine Stone , Uric Acid Stone }, volume = {23}, Number = {2}, pages = {157-163}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1180-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1180-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Rashidi, A. and Ataei, S. and Poorolajal, J. and Zeaati, F.}, title = {Evaluation of Community Pharmacists Performance in Management of Cough, Diarrhea and Common Cold using OTC Medication Requests in Hamadan in 2015}, abstract ={Introduction & Objective: Pharmacists usually encounter requests for over the counter drugs. How a pharmacist performs in evaluating patients' signs and symptoms, treating them, and moreover his or her approach in prescribing over the counter (OTC) medications were the main goals of this study.     Materials & Methods: In this cross- sectional study, the scenarios of cough, diarrhea and common cold were obtained from questionnaires. These scenarios were then designed by determining key questions. From the overall pharmacies in Hamadan, for each of the three scenarios, 46 pharmacies were randomly selected and analyzed. Performance of pharmacists, including their interventions on over the counter counseling, asking key questions, explaining drugs' side effects and interactions, and their approach of prescribing medications, were measured. Moreover, the influence of pharmacists' gender and type of the pharmacy were determined. Results: In 41 out of 179 visits, pharmacists were not present in the pharmacy (22.9%), mostly in suburban pharmacies. The pharmacists' performances in explaining drug interactions were significantly better in urban pharmacies in comparison with suburban ones. Moreover, suburban pharmacies and male pharmacists, in comparison with urban pharmacies and female pharmacists, prescribed more drugs. Conclusion: This study shows that despite the pharmacists asking the key questions ,the majority of pharmacists made weak recommendations. In order to improve pharmacists performances, modification of  educational system for pharmacy students in addition to the continuous and effective supervision of  authorities on pharmacists' performance in  OTC drugs is suggested.}, Keywords = {Common Cold , Cough , Diarrhea , Over The Counter Medications}, volume = {23}, Number = {2}, pages = {164-171}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1181-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1181-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Nouri, F. and Raoofi, A. and Dadfar, S.}, title = {Antifungal Activity of Lavandula Angustifolia and Quergues Infectoria Extracts in Comparison with Nystatin on Candida Albicans}, abstract ={Introduction & Objective: Nowadays,herbal extracts are used to treat diseases, especially infectious ones. Candida albicans is the most common causes of oral opportunistic infections.In this study, antifungal effects of two herbal extracts were evaluated on an oral pathogen i.e. Candida albicans. Materials & Methods: In this descriptive- analytic study, the Department of Prosthodontics, ,Tehran University of Medical Sciences, school of  Dentistry the oral samples of 25 patients with denture stomatitis were collected using sterile swabs. Then the isolated candida albicans and standard candida albicans PTCC 5027 were cultured. The antifungal effect was evaluated with disk plate method. Nystatin and methanol were used as positive and negative control groups, respectively. The power of antifungal activity was evaluated with the inhibition zone diameter of each of the extracts.   At the end, the data were analyzed by ANOVA and Friedman statistical tests. Results: Results showed that extracts of Querques infectoria had great antifungal effects. There was not statistically significant difference between nystatine and Querques infectoria extract (P>0.05) however , Querques infectoria was statistically more effective than lavender extract and nystatin showed the highest antifungal activity (P <0.001). Conclusion: This study showed that plant extracts had positive effects on Candida albicans as compared to nystatin. Thus, we hope to find new herbal medicines and compounds to treat candidiasis in the future.}, Keywords = {Candida Albicans , Lavender Extract , Nystatin , Querques Infectoria }, volume = {23}, Number = {2}, pages = {172-178}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1182-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1182-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {NikkhahRankohie, M. and Soheilifar, S. and Morshedi, E. and Torabi, S. and Kafilzade, S.}, title = {Gelofen Induced Hypersensitivity: A Rare Case Report}, abstract ={Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs commonly prescribed in dental practice for the management of pain and swelling. But, rarely hypersensitivity reactions are reported.     Case Report: A 28 year old woman underwent periodontal plastic surgery (gingival graft). Postoperative analgesics (400 mg Gelofen ,oral) and antibiotics were administrated  for the patient. Three hours after discharge of patient, she complained of  redness, itching , rapid swelling of her eyes in 10 minutes, and  watery eye discharge 1 hour after taking the drugs. She was treated with 8mg/2ml mg Dexamethasone IM at the dental department and with Hydrocortisone 100mg/ml IM and antihistamine drugs at the hospital. Conclusion: There are no published protocols and sensitivity and specifity of skin pick testing and patch testing for Gelofen. So avoidance of re-exposure is the best management strategy. The use of Cox-2 specific medications would be a proper alternative for pain relief.}, Keywords = {Analgesia , Hypersensitivity , Non-Steroidal Anti-Inflammatory drugs }, volume = {23}, Number = {2}, pages = {179-183}, publisher = {Hamadan University of Medical Sciences}, url = {http://sjh.umsha.ac.ir/article-1-1183-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1183-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Matini, Mohammad and Golmoradi, Kharaman and Maghsood, Amir Hossein and Fallah, Mohamm}, title = {The Prevalence of Trichomoniasis and Metronidazole Susceptibility of the Isolates in Ghorveh, year 2015}, abstract ={Introduction & Objective: Trichomoniasis is one of the most common non viral sexually transmitted diseases caused by Trichomonas vaginalis. The aims of this study were to determine the prevalence of the infection and to consider the metronidazole susceptibility of the T. vaginalis isolates. Materials and Methods: This cross sectional study was conducted on 670 women attending to gynecology clinics in Qorveh, Kurdistan province, in 2015. Diagnosis of trichomoniasis was performed by using Dorset culture medium and wet mount methods. In vitro drug susceptibility testing was done aerobically after establishment of the isolates in axenic culture medium, Diamond.  Results: From 670 vaginal samples, eight (1.2%) and four (0.6%) of them were positive for T. vaginalis by wet mount and cultured methods, respectively. Fifty percent of the infected individuals aged from 35 to 44 years old and who were illiterate (P<0.05). Clinical signs and symptoms of trichomoniasis were vaginal discharge, itching, burning sensation, dyspareunia, abdominal pain and greenish discharge. All of the parasites were sensitive to metronidazole with mean of MIC and standard deviation of 1.9 and 0.85µg/ml, respectively.   Conclusion: Although, the prevalence of trichomoniasis is relatively low in the studied population but due to the importance of sexually transmitted diseases in public health, strategic measurements are necessary to prevent and control of the infections.  }, Keywords = {Trichomonas vaginalis, Parasitic Sensitivity Tests, Prevalence, Kurdistan, Metronidazole}, volume = {23}, Number = {3}, pages = {185-192}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23032}, url = {http://sjh.umsha.ac.ir/article-1-1157-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1157-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Hajiahmadi, Fahimeh and Safari, Nasim and Alijani, Pegah and Rabiei, Mojgan and Masomian, Neda and Arabestani, Mohammad Rez}, title = {Assessment of the Prevalence of Class I and II Integrons of Escherichia coli and Klebsiella pneumoniae Isolates From Hospitals of Hamadan}, abstract ={Introduction: Due to the increasing trend of antibiotic resistance in the Enterobacteriaceae family, treatment of infections caused by these bacteria has been difficult. The aim of this study was to identify of class I and II integrons and associated gene cassettes in clinical isolates of Escherichia coli and Klebsiella pneumonia. Methods: In this cross-sectional study, of 500 strains isolated from clinical samples of hospitals in Hamadan, Iran, in 2015, 129 K. pneumoniae and 118 E. coli isolates were isolated and examined. Then, the isolates were verified by standard biochemical methods and PCR was performed on class I and II integron genes using specific primers. Results: The results of this study showed that the prevalence of class I integrons was more than class II integrons. The most frequent class I integron gene cassettes were aadA1 and dfrA7 respectively, which are resistance encoding genes for kanamycin and trimethoprim. Conclusions: The result of this study indicated a high prevalence of class I integrons in E. coli and K. pneumonia isolates. Thus, the identification of these resistance genes for infection control programs and to prevent the spread of resistant strains is very important}, Keywords = {Escherichia col, Integron, Klebsiella pneumoniae, Antibiotic Resistance}, volume = {23}, Number = {3}, pages = {193-201}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23036}, url = {http://sjh.umsha.ac.ir/article-1-1269-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1269-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Karkhanehie, B and Farhadian, M and Lashgary, M}, title = {Evaluation of the "Reverse Flow" Technique in Prevention of Post Dural Puncture Headache in Cesarean Section Under Spinal Anesthesia}, abstract ={line"> <Introduction: Post Dural Puncture Headache (PDPH) is a relatively common complication aftr spinal or epidural anesthesia, myelography and lumbar puncture. Despite numerous studies that have identifid many therapies, debate and survey continues on the best technique to prevent this complication. Threfore, the purpose of this study was to evaluate the ''Reverse Flow" technique in prevention of headache aftr dural puncture in cesarean section under spinal anesthesia. Methods: In this single blind, simple randomized clinical trial, patients were divided to two groups: intervention and control. Each group constituted of 120 patients. In the intervention group we mixed 3 mL Marcaine 0.5% with 1 cc fentanyl and injected 3 mL of this mixture into subarachnoid space by 24-gauge quincke spinal needle then simultaneously with injection of 1mL of this mixture, the needle was withdrawn. In the control group only 3 mL of this was mixture was injected into subarachnoid space and we had no injection while needle withdrawing. Thn we evaluated headache at 6, 12, 18, 24, 48 and 72 hours aftr the operation and if patients had headache we determined severity of pain with the Numerical Rating Scale. Results: Incidence of headache in the intervention group was 2.5% and 9.2% in the control group (P = 0.028). Th average severity of headache was 5.66 ± 3.21 in the intervention group and 5.18 ± 2.89 in the control group (P = 1). Th mean age was 29.26 ± 5.95 in the control group and 27.89 ± 5.58 in the intervention group (P = 0.066). Th mean age in patients, who suffred from headache, was 24.66 ± 3.05 in the intervention group and 29.72 ± 6.54 in the control group (P = 0.23). Patients who complained of headaches were younger than others. conclusions: Ths study indicated that use of "Reverse Flow" technique in cesarean section under spinal anesthesia reduces PDPH. Th incidence of PDPH in patients, who have not received this technique, was 3/7 times more than patients, who have received this technique. Also the onset of headache in the control group happened earlier than in the case group.  }, Keywords = {Headache, Dural Puncture, Spinal Anesthesia, Cesarean Section,}, volume = {23}, Number = {3}, pages = {202-206}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230311}, url = {http://sjh.umsha.ac.ir/article-1-1356-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1356-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Khamverdi, Zahra and Yarmohammadi, Ebrahim and Kasraei, Shahin and Khazaei, Mahs}, title = {In vitro Comparison of the Effect Cola Beverage on Surface Hardness of Siloran-Based (p90) and Methyl Methacrylate-Based (p60) Composites}, abstract ={Introduction: The characteristics of a suitable restoration material is having acceptable mechanical properties, protecting teeth against decay and ease of use in clinics. Diet can affect properties of restorative materials in the mouth. Since amongst important properties of composite restorations are mechanical properties such as hardness, the aim of this study was evaluation of the effect of Coca-Cola Beverages on surface hardness of a silorane based (p90) and methyl methacrylate (p60) composites. Methods: In this experimental study, thirty disc-shaped specimens (5 × 2 mm) of each of methyl methacrylate based (Filtek p60, 3M Dental Products, USA) and a silorane based (Filtek p90, 3M Dental Products, USA) composite resins were prepared, according to manufacturers' instructions. Specimens were randomly divided to four groups as follows (N = 15): G1: Filtek p90 without exposure to Coca-Cola, G2: Filtek p90 with exposure to Coca-Cola, G3: Filtek p60 without expure to Coca-Cola, G4: Filtek p60 with expure to Coca-Cola. The specimens were exposed to regular soft drinks Coca-Cola, (Khoshgovar, Tehran, Iran) at room temperature for seven days with a frequency of three times daily for 20 minutes at a time. In the remaining times of the day, they were kept in distilled water. Then, micro hardness measurements were made for each specimen with a Vickers hardness testing machine (Buehler, Lake Bluff, IL, USA) under 500 g of force for 15 seconds. Data were analyzed using SPSS 18 and independent t-test at a significance level of 0.05 Results: Micro hardness values of four groups were G1: 68.28 ± 2.65; G2:59.56 ± 6.61; G3: 93.5 ± 2.38; and G4:86.76 ± 5.47, respectively. The results of this study showed that Coca-Cola reduces the surface hardness of the two composite materials (P < 0.05). Conclusions: The results showed the hardness of both Filtek p90 and Filtek p60 composite significantly decreases with Coca-Cola yet the reduction was equal.}, Keywords = {Hardness, Silorane Resin, Composite Resins}, volume = {23}, Number = {3}, pages = {207-213}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230312}, url = {http://sjh.umsha.ac.ir/article-1-1272-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1272-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Rahmati, Khadijeh and Maghsoud, Amir Hossein and Matini, Mohammad and MotevalliHaghi, Mousa and Fallah, Nazanin and Fallah, Mohamm}, title = {Study of Intestinal Helminthes of Stray Dogs and Their Public Heath Importance in Hamadan City}, abstract ={Introduction: Intestinal helminthesof dogs are a serious threat to human health and may cause dangerous diseases such as: hydatidosis and visceral larva migrans,thatwhich cause severe complications in human. The aim of this study was to determine the prevalenceof intestinal helminthes of stray dogs in Hamadan city, Iran.. Methods: A total of 103 stray dogswere shot in the inner and around of the city in year 2015. Following necropsy, the intestines' contents of dogs were examined for helminthes macroscopically. Then, the collected worms, after washing with saline,were counted and identified according to being Nematode, Cestodeor Acantcephala. Then, collected Nematodes were put in glass containers containing 70% ethanol-glycerine and Cestodes after processing on slides were put in the 10% formalin. To identify the species of helminthes, the Cestodes were stained using carmine acid and Nematodes were cleared in lacto-phenol. Results: Result indicated that, 74(71.8%)stray dogs were infected at least by one species of intestinal helminthes. The species of parasites were as follows: Echinococcus granulosus 37.9%, Dipylidium caninum 51.5%, Toxocara canis 19.4%, Taenia hydatigena 24.3%, T. multiceps 2.9%, T. ovis 1.9%, Mesocest oideslineatus 4.9%, and Acantho cephala 5.8%.There was no association between insex, season and region with prevalence of intestinal helminthes (P > 0.05). On the other side, there was a significant deference (P < 0.05) between the prevalence of intestinal helminthes and dogs' age. Conclusions: This study indicatesd that,infection rate of helminthes in stray dogs is washigh in Hamadan city. These parasites are important in terms of human health and economic aspects. Therefore, it is more essential that public health authoritiesto develop control strategies for stray dogs' population.}, Keywords = {Helminths, Public Health, Dogs}, volume = {23}, Number = {3}, pages = {214-220}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23033}, url = {http://sjh.umsha.ac.ir/article-1-1273-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1273-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Bazzazi, Nooshin and Eslami, Fatemeh and Pahlavani, Pouyan and Akbarzadeh, Siamak}, title = {Dry Eye Following Cataract Surgery in Women Over 50 Years Old}, abstract ={Introduction: Dry eye is a common problem amongst post-menopausal women. Cataract surgery may worsen symptoms of dry eye and this can influence the quality of life in patients. This study was performed to evaluate the incidence and severity of dry eye symptoms after phacoemulsification surgery. Methods: This case-series study was performed on 43 women aged over 50 years during 2013-2014. Patients underwent phacoemulsification surgery on one eye. Symptoms of the operated and contra lateral eye were analyzed by c2 statistical test and SPSS software, preoperative and one month after the surgery. Results: One month after the surgery, the mean value of incidence and severity of dry eye in operated and non-operated eyes were 90.06 ± 3.5, 80.96 ± 3.55, 71.11 ± 3.52, and 63.51 ± 3.04, respectively. The difference between the two groups was significant (P < 0.001). Schirmer’s test, TBUT and corneal staining showed no significant difference (P ≥ 0.05). Conclusions: Cataract surgery may lead to worsening of dry eye symptoms. Treatment of dry eye before cataract surgery is an important issue to prevent ocular surface damage.}, Keywords = {Cataract Surgery, Menopause, Dry Eye Syndromes}, volume = {23}, Number = {3}, pages = {221-226}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230310}, url = {http://sjh.umsha.ac.ir/article-1-1274-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1274-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {IzadiDehnavi, Saeideh and Yaghubi, Hamid and HeydariNasab, Leyl}, title = {Simultaneous Changes of Depression and Anxiety Symptoms with Variations in Sexual Function of Young Married Women}, abstract ={Introduction: The present study aimed to examine changes in depression and anxiety symptoms and their correspondence to fluctuations in sexual dysfunction with daily diary approach. Methods: The present study was of the correlation type, conducted in 2015. To investigate this study, at first, 120 young married women from the University of Tehran were selected in a manner available nationwide. First, using female sexual distress inventory, Beck depression inventory and Beck anxiety inventory, the baseline was conducted. Then, for 14 days, mood and anxiety symptoms and sexual function by the mood and anxiety symptoms questionnaire and female sexual function index were evaluated and finally, data were obtained and analyzed by HLM7. Results: In the study of simultaneous relation, there was more general distress, with less orgasm (P = 0.001), vaginal lubrication (P = 0.001), and anhedonia, with less desire (P = 0.001). Also, anxious arousal was associated with less sexual arousal (P = 0.001) and desire (P = 0.001). Conclusions: In general, simultaneous changes in symptoms of depression and anxiety with changes in sexual function were associated}, Keywords = {Depression, Anxiety, Sexual Behavior}, volume = {23}, Number = {3}, pages = {227-236}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23034}, url = {http://sjh.umsha.ac.ir/article-1-1275-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1275-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Zebarjadi, Sara and Soltanian, Ali Reza and Faradmal, Javad and Asgari, Ghorb}, title = {The Application of Dose-Response Models to Determine the Median Effective Adsorbent Bone Char Dose to Remove Fluoride From Drinking Aqueous Solutions}, abstract ={Introduction: In studies of the adsorption of pollutants onto different adsorbents, determining the adsorbent dose of the most important characteristics must be considered. The aim of the study was the determination and modeling of dose-response bone char fluoride removal from aqueous solutions and comparison of the adsorption isotherm models with dose-response models from the perspective of adsorption. Methods: In this experimental study, bone char was prepared by using an electric furnace at 450˚C in two hours. Sorting the adsorbent was conducted by standard sieve ASTM in the range of 18-35 meshes and its characteristics were determined with conventional methods. The concentration of fluoride was measured according to the recommendation of manufacturer (HACH) with Dr-5000 of regent fluoride. Dose-response models were fit to the data and parameters were estimated. Based on the quality of fitness indicators, the adsorption isotherm models were compared with dose-response models. Analysis of the data in this study was performed using the R software version 3.1.2 and stats package. Results: Fit indexes (AIC and R2) showed that the most appropriate model for the data in pH= 10, concentration = 10 and pH = 7, concentration = 20 was the Emax model and in pH = 7, concentration = 10 and pH = 7, concentration = 15 the quadratic model. According to these models, the median of effective dose on bone char at removal of fluoride was determined 0.11 g in concentration of 10 mg/L and pH = 10. The maximum effective dose was determined 1.25 g in concentration of 20 mg/L and pH = 7. The index (AIC) showed that quadratic dose-response models better fit to adsorption data than adsorption isotherm models. Conclusions: The median and maximum effective doses of bone char at removal of fluoride were estimated by statistical models more accurately. In addition, determining the goal dose was performed using modeling method, which was more economic than repeated testing, and the performance time was also more cost-effective. Quadratic dose-response model can be a good alternative for adsorption isotherm models in the adsorption behavior.}, Keywords = {Dose-Response Models, Bone Char, Fluoride, Adsorption Isotherm Models}, volume = {23}, Number = {3}, pages = {237-248}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23035}, url = {http://sjh.umsha.ac.ir/article-1-1276-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1276-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Rudkhaneei, Kamran and Aghajaninasab, Monireh and Abbasi, Masumeh and Mohammadghasemi, Fahimeh}, title = {Effect of Apple Vinegar on Spermatogenesis and Serum Total Antioxidant Status in Rats Under High Fat Diet}, abstract ={Introduction: Obesity and high fat diet (HFD) has side effects on male fertility. The aim of this study was to evaluate the effect of apple vinegar on spermatogenesis and serum total antioxidant status (TAS) in rats under HFD. Methods: Twenty-four Wistar male rats were divided to three groups, including (n = 8): control, HFD, HFD + apple vinegar. The control group received 16.6 kcal/day and the other two groups received HFD containing 51.6 kcal/day. After 16 weeks, group 3 received 5% apple vinegar in drinking water orally for six weeks. At the end of the experiment, epididymis sperm parameters including: count, morphology and motility, were measured. Serum level of TAS, testosterone and estradiol was assayed with enzyme linked immunosorbent assay (ELISA). Testicular apoptosis was assayed with terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) and spermatogenesis was studied with quantitative histologic method. Statistical analysis was performed using analysis of variance (ANOVA) and Tukey’s test. Results: Apple vinegar increased count and forward motility of sperms, when compared with HFD (P < 0.05). However, it was not effective on morphology. Numbers of apoptotic cells reduced in the vinegar-treated group (P < 0.001). Vinegar increased serum levels of testosterone and TAS compared with HFD (P < 0.05). However, estradiol level was not changed. Vinegar reduced the lee index, when compared with HFD (P < 0.001). The numbers of spermatogonia, primary pachytene and leptotene spermatocyte, and round spermatids were not changed. However, the numbers of elongated spermatids were increased compared with HFD (P < 0.05). Conclusions: This study indicated that daily use of apple vinegar in rats under HFD for six weeks improved spermatogenesis through reduction of testis apoptosis, increasing serum TAS and testosterone.}, Keywords = {High Fat Diet, Obesity, Apple Vinegar, Antioxidant, Spermatogenesis}, volume = {23}, Number = {3}, pages = {249-258}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23037}, url = {http://sjh.umsha.ac.ir/article-1-1277-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1277-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Eshghi, Gholamreza and Lohrasbi, Farzad and Soltanian, Alireza and Rezanejad, Aliasghar and Alirezaei, Pedram and Khezrian, Leil}, title = {Effect of Serum Testosterone and Dihydrotestosterone Levels in Patients With Seborrhea}, abstract ={Introduction: Seborrhea is a condition of sebaceous glands hyperactivity and increase in the secretion of sebum on head and face surface. Sebaceous glands hyperfunction causes oily and glassy appearance with large pores on the skin. The effect of androgens on providing seborrhea is controversial. Since sufficient and definite information about testosterone and dihydrotestosterone in seborrhic cases is not available, this study was carried out to evaluate effect of serum testosterone and dihydrotestosterone levels in the seborrheic patients. Methods: In this case-control study, 36 patients with seborrhea and 36 control individuals, under 40 years of age were selected. Serum testosterone and dihydrotestosterone levels were measured in ng/mL. Data were analyzed using SPSS v.16, Chi-square and t-tests (α = 0.05). Results: Twenty-three males and 49 females, who referred to the dermatology department of Farshchian Hospital of Hamadan, participated in this study. The age distribution of the participants was between 19 and 39 years old with mean age of 28.66 ± 5.71. The mean level and SD of serum testosterone in control and case groups was 2.83 ± 2.75 and 1.21 ± 1.09, respectively, while dihydrotestosterone level was 500.38 ± 373 and 350.99 ± 228.2 ng/mL. Means and SDs values of serum testosterone were 2.83 ± 2.75 and 1.21 ± 1.09 and dihydrotestosterone was 500.38 ± 373 and 350.99 ± 228.2 ng/mL in case and control groups, respectively. The findings showed that there were differences in serum testosterone and dihydrotestosterone values between case and control groups (P< 0.05). Conclusions: According to the results of this study there is a positive relationship between serum testosterone and dihydrotestosterone values with seborrhea}, Keywords = {}, volume = {23}, Number = {3}, pages = {259-265}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23038}, url = {http://sjh.umsha.ac.ir/article-1-1278-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1278-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Gholamrezayee, Simin and HosseiniRamaghani, Nasrin Alsadat and Panahi, Hadi and Gholipour, Mohamm}, title = {The Comparison of Updating Function of Working Memory in Three Groups of Substance Abusers (Heroin, Opium), Those Treated with Methadone and Normal Controls}, abstract ={Introduction: Chronic use of opiates is associated with a wide range of neuropsychological deficits. Therefore, this study aimed to evaluate one of the neuropsychological functions, updating function of working memory, in three groups, including substance abusers (heroin and opium), those under treatment with methadone, and normal controls. Methods: The method of this study was causal-comparative. Ninty individuals in three groups, including substance abusers (n = 30), those under treatment with methadone (n = 30), and normal controls (n = 30) were selected from people referred to the addiction treatment Clinics in Shiraz (2015) with the purposeful sampling method. All subjects were evaluated regarding working memory updating and self-reported mental effort scale and the results were analyzed by Multiple Analysis of Variance (MANOVA) test and Tukey post hoc test with SPSS software (version 23). Results: The results showed a significant difference between the three groups in the updating function of working memory; so that effectiveness and efficiency of processing in the normal group was better than the other two groups and the performance effectiveness and efficiency of processing in the group under methadone treatment was better than substance abusers group. Conclusions: substance abuse has a negative effect on neurological function. Given that the group of methadone treatment had better performance in the updating function of working memory than the group of substance abusers, these results provide hope that the effects of examined drugs on working memory is not permanent and we can look for psychological interventions to treat these patients and prevent problems recurrence}, Keywords = {Working Memory, Performance Effectiveness, Processing Efficiency, Substance Abuse}, volume = {23}, Number = {3}, pages = {266-276}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23039}, url = {http://sjh.umsha.ac.ir/article-1-1280-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1280-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {RastgooHaghi, Alirez}, title = {A Rare ‍Case Report of Papillary Glioneuronal Tumor}, abstract ={Introduction: Papillary Glioneuronal Tumor (PGNT) is a rare tumor with approximately 70 cases reported in the last decade. This tumor is more common in young adults and is the most common clinical manifestation of headaches and seizures. This tumor has an indolent clinical behavior. Regarding gender prevalence there is no detailed epidemiological information available, because of the rarity and newness of this tumor. Case Presentation: A 32-year-old female patient with a sudden headache and blurred vision referred to our hospital. The magnetic resonance imaging (MRI) revealed a heterogeneous mass with dimensions of 35 × 33 × 20 mm in the right frontal lobe. Histologically, a biphasic tumor composed of a glial component arranged in papillary architecture overlaying hyalinized vessels, associated with interpapillary areas, containing monotonous oligodendrocyte-like and ganglion-cells were seen. The immunohistochemical staining indicated glial fibrillary acidic protein (GFAP)-positive glial cells and positive synaptophysin and neuron-specific enolase (NSE) in interpapillary neurocytes. Conclusions: Papillary Glioneuronal tumor is a rare tumor with slow growth and low grade. The possibility of transformation to high-grade tumor, is low. Due to having the structure of pseudopapillary, along with clinical and radiographic characteristics, it must be distinguished from other variants of glioneuronal tumor mix.}, Keywords = {Papillary Glioneuronal Tumor, Frontal Lobe, Low Grade}, volume = {23}, Number = {3}, pages = {277-280}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23031}, url = {http://sjh.umsha.ac.ir/article-1-1281-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1281-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2016} } @article{ author = {Homayounfar, Sh and Khansari, N and Fariba, F}, title = {Echocardiographic Evaluation of Indices of Right Ventricle Dysfunction in Pulmonary Hypertension}, abstract ={Introduction: Echocardiography is usually the first modalities of imaging to evaluate the structural and functional disorders of the heart and great vessels, and colored flow and Doppler images are able to perform hemodynamic and bloodstream evaluations. The goal of this study was the investigation of right ventricular function using echocardiography in patients with pulmonary artery hypertension. Methods: In this cross-sectional study, the study population included all the patients with pulmonary artery hypertension for any reason, and their diagnoses using echocardiography and measurement of pulmonary artery pressure were confirmed, which were higher than 25. The number of samples was 80 and patients underwent echocardiography with two-dimensional and tissue doppler imaging. Data were analyzed using SPSS software version 16 and Chi-squared test, Pearson’s correlation coefficient and t-test. The significance level was considered less than 0.05. Results: The results of statistical tests showed that the means of FAC, TAPSE, and TIE indexes in the group with PVR less than 2 were significantly higher than the means of FAC (P = 0.006), TAPSE (P = 0.04), and TIE (P = 0.01) indexes in the group with more PVR, and were equal to 2 in this study. Also, the differences between the mean of normal and abnormal values of FAC, SWAVE, and TIE indexes in patients with normal PVR were not significant, while these differences were significant in patients with abnormal PVRs. Conclusion: In echocardiography investigations of right ventricular function in patients with pulmonary artery hypertension, the values obtained from FAC, SWAVE and TIE indexes and TAPSE had high diagnostic confidences in these patients. Therefore, these items were disturbed as a result of increase in the degree of resistance of pulmonary bed, and were good criteria to evaluate the right ventricular function in these patients. In the meantime, FAC values were more sensitive to the abnormal values of PVR due to the high frequency of its abnormal values in the range of abnormal PVR, and it was a good criterion to evaluate the right ventricular function in patients with pulmonary artery hypertension.}, Keywords = {Two Dimensional,Echocardiography,Doppler Echocardiography,Right Ventricle,Pulmonary Artery,Hypertension}, volume = {23}, Number = {4}, pages = {281-287}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23045}, url = {http://sjh.umsha.ac.ir/article-1-1377-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1377-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Jahanshahi, J and Yazdani, D}, title = {Effct of Topical Vancomycin on Eradication of Staphylococcus aureus in Sinonasal Polyposis Aftr Functional Endoscopic Sinus Surgery}, abstract ={Introduction: One of the main theories in development of sinonasal polyposis involves the effect of Staphylococcus aureus super antigens and microbial biofilm. The aim of this study was to evaluate the effect of topical vancomycin on Staphylococcus aureus removal from sinus mucosa following surgery. Methods: In this randomized triple-blind clinical trial, 35 patients, who underwent sinus polyp surgery and whose sinus culture was positive for Staphylococcus aureus before surgery, were divided to two groups. For the case group, nasal irrigation with normal saline solution containing vancomycin and for the control group, nasal irrigation with normal saline solution was administered for eight weeks. During the second month of treatment, all patients underwent nasal endoscopy. Patients were assessed for Staphylococcus aureus culture during the second month. All data were analyzed using two independent samples t-test and Fisher's exact tests. The level of statistical significance was considered as P < 0.05. Results: Culture of Staphylococcus aureus in the second month was significantly lower in the case group than the control one (P < 0.05). Conclusion: It seems that the use of topical vancomycin solution has an effect on eradication of Staphylococcus aureus in sinonasal polyposis after surgery}, Keywords = {Polyps,Nasal Sinuses,Staphylococcus aureus,Vancomycin}, volume = {23}, Number = {4}, pages = {288-292}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23041}, url = {http://sjh.umsha.ac.ir/article-1-1378-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1378-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Ghiasian, M and Mazaheri, Sh and HashemiRahbarian, F}, title = {Factors Delaying Hospital Arrival Aftr Acute Stroke Onset}, abstract ={Introduction: Optimal time of referral after stroke and the use of new therapies, such as r-tPA and blood pressure control, could accelerate symptoms recovery after stroke. The aim of this study was to investigate factors contributing to the delay in referral to hospitals after the occurrence of acute stroke. Methods: This analytic-descriptive study included 425 patients, who had referred to the Hamadan Farshchian hospital during years 2015 and 2016. Demographic data, time of referring to medical center, the time of occurrence of stroke, risk factors, clinical symptoms of stroke, way of referring, distance from medical center and type of stroke by using a questionnaire and checklist were recorded. The SPSS (version 16) software was used for all calculations. Results: The mean age of patients in this study was 70.12 years old. Overall, 260 patients (61.2%) were male and 85.6% had ischemic stroke. Mean time of referral to first treatment center and Farshchian hospital was 2.06 and 4.77 hours, respectively. A total of 36.2% patients arrived to Farshchian hospital, within less than 2 hours. Factors that prolonged time to presentation were male gender, ischemic stroke, low education, being at a location far from the medical center, referral from other medical centers, being single, having no witness during stroke, and having a stroke at home, and during night. The most common symptoms in patients who were referred within less than two hours were confusion and loss of consciousness with frequency of 29.2%. The most common risk factor in 61.4% of patients, who were referred within less than 2 hours, was high blood pressure. Conclusion: This study showed mean time of referral for treatment after stroke was high. Influential elements that could possibly delay hospital arrival include, being at a location far from the medical center, no adequate knowledge about stroke symptom, having stroke at night, not referring directly to the medical center, being single, and no witness during stroke. .}, Keywords = {Acute Stroke,Emergency Care,Pre-Hospital Delay}, volume = {23}, Number = {4}, pages = {293-299}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23043}, url = {http://sjh.umsha.ac.ir/article-1-1379-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1379-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Bahadori, M and Eshghi, G and Khezrian, L and Seifrabiei, MA}, title = {Comparative Study of Thrapeutic Effcts of%20 Azelaic Acid and %4 Hydroquinone Cream in Treatment of Melasma}, abstract ={Introduction: Melasma is a recurrent, symmetric, and chronic acquired hyperpimentation that presents gray-brown macules and patches with determined margins in areas exposed to light. There are many treatment options with different efficacies and side effects. In this study the therapeutic effect of 20% azelaic acid and 4% hydroquinone in treatment of melasma was assessed. Methods: In this clinical trial, the study population consisted of all patients with clinical diagnosis of melasma, who referred to the outpatient clinic of dermatology of Hamadan, Farshchian Hospital from December 2013 to July 2014. A total of 44 patients were recruited. Patients were randomly divided to two groups and each group was treated with either azelaic acid or hydroquinone for four months. The MASI score was used to evaluate the improvement. P values of ≤ 0.05 were considered significant. Results: Of 44 patients, 21 received 4% hydroquinone and 23 received 20% azelaic acid, with random allocation. Both groups were similar with respect to gender and age, and there were no significant differences between the two groups. The MASI score in both groups had a decreasing trend over time, and at the end of the fourth month, a significant difference was found between the two groups (P = 0.006). The overall mean MASI score in both groups had a significant difference at different times and during the entire trial period, mean MASI score of 20% azelaic acid was lower than 4% hydroquinone (P = 0.001). Conclusion: Based on this study, we could conclude that 20% azelaic acid in comparison with 4% hydroquinone had better effects on treatment of melasma. Therefore, 20% azelaic acid is a good alternative for 4% hydroquinone in treatment of melasma.}, Keywords = {Azelaic Acid,Hydroquinone,Melasma}, volume = {23}, Number = {4}, pages = {300-305}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230411}, url = {http://sjh.umsha.ac.ir/article-1-1380-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1380-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Habibipour, R and Sadeghian, M and Seif, A and Bayat, S}, title = {The Effct of Silver Nano-Particles on Removing Klebsiella pneumoniae from Industrial Residues}, abstract ={Introduction: Progress in nano-science and nanotechnology in the past decade has provided many opportunities to study the biological effects of nanoparticles, in particular their anti-bacterial effects. The aim of this study was to evaluate the antimicrobial properties of silver nanoparticles for the removal of Klebsiella pneumoniae isolated from industrial effluents. Methods: In this experimental study, after sampling polluted industries, coliform and total coliform measurements of fecal industrial wastewater microbiology were performed by standard methods. The antimicrobial activity of silver nanoparticles on the bacteria (Klebsiella pneumoniae isolates and standard) was evaluated with the agar dilution method and broth dilution. One milliliter suspension containing bacteria at 1.5 × 108 CFU/mL was added to each sample followed by incubation at 37°C for 24 hours. After the mentioned period, the optical density at a wavelength of 600 nm was used to measure the concentration of bacteria. Next, 100 mL of each dilution was transferred to solid medium followed by incubation. The results were analyzed with SPSS 22 software. Results: Fecal and total coliform bacteria pollution of textile wastewater was approved, and Klebsiella pneumoniae (textile industry pollution index) were isolated. With increasing concentration, the antibacterial activity of silver nanoparticles increased while the number of colonies decreased. Although none of the concentrations were able to eliminate the bacteria, a non-significant decrease in the number of bacteria was observed. Conclusion: The results of the study showed that the type of bacteria and concentrations of silver nanoparticles antimicrobial properties of silver nanoparticles are risk factors. Although the concentrations used were effective against bacteria yet they did not lead to complete elimination of bacteria Therefore potential impact of nanoparticles for use requires further research and economic factors and other factors should be considered in their application.}, Keywords = {Klebsiella pneumoniae,Nanoparticles,Silver}, volume = {23}, Number = {4}, pages = {306-313}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23046}, url = {http://sjh.umsha.ac.ir/article-1-1381-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1381-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Leili, M and BahramiAsl, F and Hesam, M and Molamahmoudi, M and SalahshourArian, S}, title = {Estimation of Diseases and Mortality Attibuted to Atmospheric NO2 and SO2 Using AirQ Model in Hamadan City, Iran}, abstract ={Introduction: NO2 and SO2 as gaseous air pollutants are involved in many global air accidents, and are respiratory tract irritants that can cause numerous health effects in humans. Therefore, due to the necessity of studies in this field and the absence of any similar study in the city of Hamadan, the aim of this study was quantification of health effects attributed to NO2 and SO2 in Hamadan city of Iran during years 2014 and 2015. Methods: This was a cross-sectional study. Primarily, required criteria pollutants and meteorological data were obtained from the environmental protection agency and meteorological agency of Hamadan city, respectively. The obtained data were validated using the World Health Organization (WHO) criteria. Required statistical indices were calculated and according to baseline incidence, relative risk and exposed populations, the different effects of pollutants were assessed. Results: According to the results, the average annual concentration of NO2 and SO2 was 1.7 and 1.6 times more than the standard, respectively. With central relative risk, the estimated attributed portion for total mortality attributed to NO2 and SO2 was 1.74 and 0.92, respectively, which is equal to death of 51.9 and 27.3 individuals during years 2014 and 2015, respectively. Conclusion: As a result, it should be stated that most of the adverse health effects attributed to SO2 and NO2 were observed in concentration ranges from 20 to 49 and 40 to 89 micrograms per cubic meter, respectively. This indicated that the concentration distribution of NO2 was wider than SO2. It can also be concluded that investigated pollutants (NO2 and SO2) had significant adverse effects on the residents of Hamadan city and before further increase in the effects, preventive measures should be taken by relevant authorities}, Keywords = {Air Pollution,Health Effct,Nitrogen Dioxide,Sulfur Dioxide}, volume = {23}, Number = {4}, pages = {314-322}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230412}, url = {http://sjh.umsha.ac.ir/article-1-1382-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1382-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Koorki, Masoud and Isfandyari–Moghaddam, Alireza and Bayat, Behrooz}, title = {Evaluation of Research Outputs at the Hamadan University of Medical Sciences Based on the Hirsch Index and m Parameter: A Scientometric Study}, abstract ={Introduction: One of the most important evaluation methods for scientific outputs of researchers and research centers is to use the Hirsch index (h-index) and m parameter. The main advantages of these indicators are simultaneous evaluation of the quantitative and qualitative of scientific production. The aim of this study was to determine the research outcomes of the faculty members of Hamadan University of Medical Sciences based on the Hirsch index and m parameter indexed in Google Scholar until end of 2016. Methods: In this scientometric and descriptive study all of the faculty members of Hamadan University of Medical Sciences (425 people) were included in the census method. With a direct view Google Scholar database and insertions of affiliation for university the Hirsch index and scientific age of people were extracted and then documented the checklist, as a result those m parameter were calculated. In the final operations and in order to data analysis software, so data analysis was carried out by software SPSS16, as well as a number of indicators and charts and graphs, descriptive statistics were used. Results: Of the total, 209 people (49.2%) have the Hirsch index. The overall mean (SD) of the Hirsch index 2.71(3.85) and m parameter 0.36 (0.44) were obtained, respectively. The maximum Hirsch index has been 17 that three members of the biochemistry, biostatistics and epidemiology and public health they earn them, respectively, and the highest m parameter was 2.16 that was awarded to the academic member of Psychiatry department. The mean of the Hirsch index and m parameter were 3.31 and 0.42 in men and 1.76 and 0.25 in women respectively, as well as for the basic sciences courses 4.97 and 0.57 and also for clinical sciences 1.72 and 0.26 were obtained. Ph.D. degree and professor grade, respectively with Hirsch index 5.01 and 9.3 and m parameter 0.58 and 0.89 were highest mean as well. In terms of scale between the two indexes studied, rank and position of all four variables did not differ. In general, department of immunology at the university, the mean of Hirsch index 9.25 and department of biostatistics and epidemiology the mean of m parameter 1.14 were top rank respectively. School of health the mean of the Hirsch index 7.02 and the mean of m parameter 0.87 has been the highest rating from two aspects among the universities obtained. In comparison between the two indices of scientometric, ranking and position of other faculties and educational departments were different from together. Conclusion: The average of the Hirsch index and m parameter of research products at the faculty members of Hamadan University of Medical Sciences, between the universities of medical sciences will be assessed average to high level and fairly good, but they are low level than international indices both qualitatively and quantitatively aspects. Hence, it is recommended that of the m parameter to be used accompanying with other scientometric indices as scientific evaluation criteria of academic researchers.}, Keywords = {Faculty Member, Google Scholar, Research Output, Scientometric}, volume = {23}, Number = {4}, pages = {323-335}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23047}, url = {http://sjh.umsha.ac.ir/article-1-1383-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1383-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Minooeianhaghighi, MH and Sehatpour, M and Shokri, H}, title = {Determination of Drug Susceptibility of Candida Strains Isolated From Patients With Recurrent Candida Vulvovaginitis and Investigation of Predisposing Factors of the Disease}, abstract ={Introduction: Recurrent Vulvovaginal Candidiasis (RVVC), which is mostly caused by Candida albicans (C. albicans), is the second common cause of genital tract infection in females. The purpose of this research was to identify Candida isolates from RVVC, identify predisposing factors and determine antifungal effect of fluconazole against Candida strains isolated from the patients. Methods: In this descriptive-laboratory study, 20 patients with confirmed diagnosis of RVVC were selected. Yeast isolates were characterized using mycological standard methods, including culture on Sabouraud dextrose agar medium and CHROM agar, germ tube test and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The susceptibility of Candida isolates against fluconazole was determined by microdilution broth method. Results: The average age of the patients was 29.43 ± 4.63 years. Candida albicans was obtained from 100% of the samples. The most common clinical sign was vaginal discharge (60%) in females with positive culture. Statistical correlations were observed between parturition frequency and low RVVC occurrence as well as between the previous antifungal therapy and RVVC occurrence. The mean minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of fluconazole against different C. albicans strains was determined as 45.3863 µg/mL and 63 µg/mL, respectively. Conclusion: Due to the uncertainty of diagnosis of this disease according to clinical symptoms and also, due to the resistance of Candida species, using culture and molecular methods are recommended as standard methods of diagnosis.}, Keywords = {Vulvovaginal Candidiasis,Candida albicans,Polymerase Chain Reaction,Vaginal Discharge,Fluconazole}, volume = {23}, Number = {4}, pages = {336-344}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23042}, url = {http://sjh.umsha.ac.ir/article-1-1384-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1384-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {HajizadehMoghaddam, A and AhmadiAvendi, E and Sayraf, R and Zare, M}, title = {Comparison of the Therapeutic Effects of Silymarin and Nanosilymarin on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles}, abstract ={Introduction: Recent studies have indicated that titanium dioxide nanoparticles (TiO2 NPs) are toxic for human. Silymarin is a well-known hepatoprotective drug. In this study, the nanoprecipitation technique was used for nanocrystals to improve the solubility of silymarin. The aim of this study was to analyze the protective role of silymarin and its nanocrystal on liver damage due to TiO2 NPs in rat. Methods: In this experimental study, rats were divided to five groups in separate cages: Control, vehicle, toxic group (150 mg/kg TiO2 NPs for three weeks orally) as well as silymarin and silymarin NPs groups (100 mg/kg for three weeks orally after TiO2 NPs administration). Then, the serum level of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) as well as the liver histological changes were investigated. Results: Oral administration of Tio2 NPs resulted in significantly elevated levels of ALT, AST and ALP of serum and significantly increased the core diameter of hepatocytes (P < 0.05). Silymarin and its nanocrystal reduced the elevated liver enzyme levels and also decreased the core diameter of hepatocytes in toxic rats (P < 0.001). Conclusion: : The results from the present study indicated that silymarin and its nanocrystal probably due to antioxidant effects cause hepatoprotective against TiO2 NPs-induced liver injury.      }, Keywords = {Titanium Dioxide Nanoparticles, Silymarin, Nanocrystal, Liver Enzymes}, volume = {23}, Number = {4}, pages = {345-351}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23048}, url = {http://sjh.umsha.ac.ir/article-1-1385-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1385-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Sardari, M and Maghsood, A and Alikhani, M Y and Fallah, M}, title = {In vitro Evaluation of the Effect of Bacterial Extract, Isolated From Infected Hydatid Cysts, on Protoscolex}, abstract ={Introduction: To date, surgery has been the treatment of choice for hydatid cyst, with regard to danger of leakage of hydatid cyst contents into viscera and production of secondary cysts, after spread of protoscolices. Different scolicidal agents get injected into cyst for preventing the secondary cyst production, which may cause different side effects in host, especially in the surrounding tissues. In this research, the scolicidal effects of bacterial extract isolated from infected hydatid cyst was evaluated. Methods: In this experimental-laboratorial study, at first, isolation and identification of the infecting bacteria of hydatid cyst were performed at the level of species. Then, total the bacterial extract was prepared by sonication method, and serial dilutions (1.1, 1.2, 1.4, 1.8, 1.16, 1.32 and 1.64) were prepared using sterile saline as the solvent. The obtained alive larvae at the times of 5, 10, 20, 40 and 60 minutes were placed in those dilutions and mean of dead protoscoleces were determined using eosin exclusive staining method. Results: The identified bacteria isolated from the infected hydatid cysts were as follows: E. coli, Staphylococcus aureus, S. saprophyticus, Proteus mirabilis and Pseudomonas aeruginosa. The extract of isolated bacteria at the mentioned times had no considerable scolicidal effects. For example, the whole extract of P. aeruginosa after 60 minutes of exposure showed a maximum of 13.17%. scolicidal effect. Conclusion: The results of this study showed low scolicidal effect of bacterial extracts isolated from hydatid cyst. Degeneration of scolices in infected cysts can be due to other reasons than bacterial extract.}, Keywords = {Bacterial Extract, Hydatid Cyst, Protoscolex, Scolicidal, Sonication}, volume = {23}, Number = {4}, pages = {352-359}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23044}, url = {http://sjh.umsha.ac.ir/article-1-1386-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1386-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {KordMostafapoor, F and Ahmadi, Sh and Balarak, D and Rahdar, S}, title = {Comparison of Dissolved Air Flotation Process for Aniline and Penicillin G Removal From Aqueous Solutions}, abstract ={Introduction: The presence of antibiotics due to toxicity and sustainability as well as organic compounds as a combination of hard biodegradable wastewater is an undesirable issue in many industries. The aim of this study was to evaluate the efficiency of dissolved air flotation process for aniline and penicillin G removal from aqueous solutions. Methods: This was an empirical-lab study to which the dissolved air flotation method was applied in laboratory scale. The effects of effective parameters including concentration of coagulant poly-aluminum chloride (PAC) (10, 20, 30, 40, 60 mg/L), coagulation time (5, 10, 15 and 20 minutes), flotation time (5, 10, 15 and 20 seconds) and saturation pressure (3, 3.5, 4 and 4, 5 atm) on the removal efficiency of aniline and penicillin G by dissolve air flotation were studied. Results: The results showed that dissolved air flotation method can reduce penicillin G and aniline up to 67.45% and 95%, respectively. The optimum condition was as follows: pH = 6, initial concentration of aniline = 200 mg/L, initial concentration of penicillin G = 25 mg/L, coagulation time = 10 minutes, flotation time = 10 seconds, pressure = 4 atm, and PAC concentration = 20 mg/L. Conclusions: Dissolved air flotation process can be an effective method to remove aniline and penicillin G from aqueous solutions.}, Keywords = {Dissolved Air Flotation, Aqueous Solution, Aniline, Penicillin G}, volume = {23}, Number = {4}, pages = {360-369}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-230410}, url = {http://sjh.umsha.ac.ir/article-1-1387-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1387-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} } @article{ author = {Alirezaei, P and Khezrian, L and GhasemiBasir, H and Khanali, S}, title = {A Case Report of Parry-Romberg Syndrome}, abstract ={Introduction: Parry-Romberg syndrome, a rare syndrome, is characterized by progressive atrophy affecting one side of the face. This disease can include the skin, subcutaneous tissue, muscles, cartilage, and underlying bony structures. Case Presentation: A 27-year-old female was admitted to the outpatient clinic of dermatology of Farshchian Hospital, with chief complaint of asymmetric facial appearance. The asymmetry started at the age of 16 and developed over a period of 4 years, then stopped. A physical examination revealed that the right side of her face, especially her chin was smaller than the left side, and there was loss of subcutaneous fat, which was associated with skin tightness. There were no systemic symptoms of other illnesses or other signs. Conclusion: The disease is self-limiting, yet, can be associated with systemic involvement such as neurological disorders. Clinical symptoms are the keys of diagnosis. A muli-lateral approach is essential to control the disease.}, Keywords = {Asymmetry, Parry-Romberg Syndrome, Face}, volume = {23}, Number = {4}, pages = {370-373}, publisher = {Hamadan University of Medical Sciences}, doi = {10.21859/hums-23049}, url = {http://sjh.umsha.ac.ir/article-1-1388-en.html}, eprint = {http://sjh.umsha.ac.ir/article-1-1388-en.pdf}, journal = {Avicenna Journal of Clinical Medicine}, issn = {2588-722X}, eissn = {2588-7238}, year = {2017} }