2024-03-28T15:23:31+03:30 http://sjh.umsha.ac.ir/browse.php?mag_id=17&slc_lang=fa&sid=1
17-453 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Side Effects of Transfusion of G6PD Deficient Blood in Neonates and Children Seyyed Hesamoddin Nabavizadeh Mozhgan Safari mo_sfr@yahoo.com Introduction & Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common metabolic disease of red blood cells. It affects about 35 millions people in the entire world. Its incidence in IRAN is estimated to be 10-14.9%. Transfusion of G6PD deficient blood produces many untoward side effects in recipients. Despite the high incidence of the disease and such risks, blood donors are not screened routinely for this enzyme deficiency. This study performed on effects of G6PD deficient blood in patients admitted in Pediatric & Neonatal ward of Yasouj Emam Sajjad Hospital for detection of proposed side effects.    Materials & Methods: Blood samples were obtained from 261 bags of blood during transfusion and the samples were checked for G6PD. Also patients receiving G6PD deficient blood were checked for hemoglobin, serum bilirubin and hemoglobinuria. Factors that tend to hemolysis in G6PD deficient patient were mentioned. Results: 37 (14.7%) of samples were G6PD deficient. 81% of donors had at least a risk factor that tend to hemolysis in G6PD deficient state. Side effects of transfusion of G6PD deficient blood included: non significant elevation of hemoglobin (55.9%), hemoglobinuria (35.3%) and increase in serum bilirubin (8.8%).   Conclusion: It is recommended that in areas where G6PD deficiency is endemic, donors’ blood must be screened before transfusion. Blood Transfusion Hemolysis G6PD Deficiency 2007 3 01 5 10 http://sjh.umsha.ac.ir/article-1-453-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Identification and Frequency of Candida Patient Isolates by CHROMagar Candida Method Seyyed Hasan Mirhendi mirhendi@tums.ac.ir Kouichi Makimura Mohammad Reza Shidfar Leila Hossienpour Introduction & Objective: Candida species can cause opportunistic infections in human. Although Candida albicans is major pathogenic species, non-albicans species of Candida such as C. glabrata , C. tropicalis and C. krusei have been increasingly reported. Identification of Candida species is essential for effective antifungal therapy and for infection control purposes. In the present study the commercial medium CHROMagar Candida was used as a differential method for identification of the yeasts isolated from patients. Materials & Methods: Sixteen standard strains of Candida and non?Candida yeasts were used as the reference cultures. 280 yeasts isolated from the patients referred to two Medical Mycology Laboratories in Tehran were cultured on the chromogenic medium CHROMagar Candida. The cultures incubated for 48 h at 35ºC and were differentiated based on the color of colonies in comparison with the standard strains. For colonies with unspecific color, a PCR-RFLP method was performed. Results: The most frequent species were Candida albicans(66.5%) followed by C. parapsilosis (8.6%), C. tropicalis (8.2%), C. glabrata (6.1%), C. krusei (4.6%), C. kefyr (2.5%), C. guilliermondii (0.7%), C. lusitania (0.35%) and Cryptococcus neoformans (0.35%). Conclusion: CHROMagar Candida can be a simple and straight-forward method for specific differentiation of medically important Candida species includingC. albicans, C. krusei, C. tropicalis and C. glabrata, but not for all Candidaisolates. More phenotypic or genotypic methods are necessary for exact identification of other Candida species. Candida CHROMagar Candida Identification 2007 3 01 11 15 http://sjh.umsha.ac.ir/article-1-454-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Evaluation of Role of C-Reactive Protein Level on Cardiovascular Events During 14 Days after Admission of Patients with Unstable Angina in the Ekbatan Hospital, Hamadan, 2002 Behshad Naghsh Tabrizi dbnaghsh@yahoo.com Farzad Emami Introduction & Objective: Unstable angina is in the center of spectrum from chronic stable angina to acute myocardial infarction. Due to high prevalence of unstable angina, it is important to find a factor that predicts prognosis and management modality. We decided to measure CRP level for the items that mentioned above. Materials & Methods: This study was a cross-sectional study that 138 patients who were admitted with unstable angina in the CCU and cardiac ward of Ekbatan Hospital in Hamedan were considered for measuring CRP level. Age, sex, period of disease, and left ventricular ejection fraction percentile were worked out. After quantitative CRP measuring and 14 days follow up, the questionnaire was completed. Results: CRP levels were 116.3 and 124.3 ng/ml in the patients with and without cardiovascular events (whole events) respectively during 14 days follow up. Recurrent unstable angina, myocardial infarction and mortality rate were higher in the patients with elevated level of CRP but need to perform coronary angiography was lower. Conclusion: CRP level had no correlation with occurrence of cardiovascular events (whole events) during 14 days follow up. Angina Unsatable C-Reactive Protein 2007 3 01 16 19 http://sjh.umsha.ac.ir/article-1-455-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Amygdala Centralis Cardiovascular Response to Renin Substrate Microinjection in Renovascular Hypertensive Rats Behnam Heshmatian behhesh@yahoo.com Mohsen Parviz Seyyed Morteza Karimian Mansour Keshavarz Hamid Sohanaky Introduction & Objectives: Previous studies have revealed that induction of two kidney-one clip (2K1C) Goldblatt hypertension in rats eliminates hypertensive response after inactivating of the Central Nucleus of the Amygdala (CA). The present study investigated the possibility of alteration in local Renin Angiotensin System (RAS) activity in CA after hypertension induction and evaluation of cardiovascular response to Renin Substrate (RS) microinjection into CA in Wistar rats. Materials & Methods: Clamps were placed on the left renal arteries to induce 2K1C Goldblatt hypertension. A similar surgery procedure without clipping was done in sham group. Rats were studied eight weeks after surgery. The Mean Arterial Blood Pressure (MAP) and heart rate (HR) were measured directly with indwelling arterial cannula under urethane anesthesia. Rats received bilateral cannulation of the CA for RS microinjection. After bilateral microinjection of consecutive doses of RS (0.5µL- 0.1, 1 & 10 µM) saline and pretreatment of losartan (10µM), saralasin(1nM) or captopril(10µM) before RS into CA, MAP and HR measured and compared between groups. Results: Bilateral microinjection of consecutive doses of RS   into CA increased MAP and HR significantly greater in hypertensive group in comparison with normotensive ones (P<0.001). Bilateral microinjection of saralasin and losartan into the CA of Goldblatt hypertensive rats produced significant decrease in MAP and HR from baseline levels. After pretreatment of saralasin, losartan and captopril effects of 1µM RS microinjection into CA of all groups were inhibited. Conclusion: These results are functionally demonstration of cardiovascular effects of RS after microinjection into CA and that effects have increased after 2K1C hypertension induction. This process may contribute in Goldblatt hypertension pathogenesis. Increased Angiotensin II (AngII) receptors or accelerated proteolytic process of RS to Angiotensin I and II may alter RS microinjection into CA outcome. Amygdala Centralis Hypertension Renin-Angiotensin System Renin Substrate 2007 3 01 20 26 http://sjh.umsha.ac.ir/article-1-456-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 The Comparison of Fracture :::union::: Duration of Shaft of Femur in Plating Method and Interlocking Intramedullary Nailing Seyyed Hamid Mousavi h_mousavi@med.mui.ac.ir Hamid Reza Rasteh Introduction & Objective: Jaundice is the most clinical finding in the neonatal period. Prolonged indirect fractures of the shaft of the femur are among the most common fractures encountered in orthopedic practice. Since the femur is the largest bone of the body and one of the principal loads bearing bone in the lower extremity, fractures can cause prolonged morbidity and extensive disability unless treatment is appropriate. In the recent years interlocking intramedullary nailing has become the technique of choice which decreases the complications and the duration of morbidity. In our country no study has bean achieved to compare this technique and traditional plating method. The aim of our study was to compare the time needed for fracture :::::union::::: of these two techniques. Materials & Methods: This study was a prospective clinical trial. 48 cases were randomly divided in two groups and were undergone plating method and interlocking intramedullary nailing. The groups were followed for bone :::::union::::: for at least one year. The information were analyzed by statistical exams (t-test, chi square , Cox regression , Kaplan meier ) Results: Interlocking intramedullary nailing technique group showed a decreased :::::union::::: time (14.4 weeks) compared with plating technique (19.6weeks) (P<0.001). The :::::union::::: time in open fracture in two groups were significantly increased (P<0.02). Conclusion: Interlocking technique is seriously recommended for treatment of femur shaft fractures because of decreased fracture :::::union::::: time and rapid rehabilitation and providing the facility for this technique is cost effective for all orthopedic surgery centers. Femur Interlocking Intramedullary Nailing Plating Bone :::union::: 2007 3 01 27 31 http://sjh.umsha.ac.ir/article-1-457-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 The Role of Nitric Oxide and Intracellular Stores of Calcium in the Protective Effect of Artemisia Annua Aqueous Extract on the Contractile Response of Aortic Rings to Alpha 1-Adrenoceptor Agonist in Diabetic Rats Turandokht Balochnejad Mojarad tmojarad@yahoo.com Mehrdad Roghani Foruzan Sadeghi Mahali Introduction & Objective: Vascular complications represent the main cause of mortality in diabetic patients. Considering the role of plants containing flavonoids in elimination of diabetic vascular disorders and the protective effect of the aqueous extract of Artemisia annua on aortic contractile response in diabetic rats, we evaluated the mechanism of vasodilating action of Artemisia annua extract in this study. Materials & Methods: For this purpose, male Wistar rats (n=36) were randomly divided into control, untreated-diabetic, and Artemisia annua aqueous extract treated-diabetic groups. For induction of diabetes, streptozotocin (STZ) was intraperitoneally administered (60 mg/Kg). Artemisia annua extract-treated group received 60 mg/Kg of extract intraperitoneally. After one month, contractile reactivity of aortic rings to phenylephrine in the presence of L-NAME and EGTA was determined using isolated tissue setup. Results: Comparing of the contractile response of aortic rings with endothelium to phenylephrine, before and after adding of L-NAME, showed a significant difference between treated and untreated diabetic rats(P<0.05). On the other hand, comparing of aortic contractile response with or without endothelium to phenylephrine in the calcium-free Krebs in the presence of EGTA showed that the difference between treated- and untreated-rats was considerable (P<0.05). Conclusion: On the basis of obtained results, it seems that the vasodilatory effect of aqueous extract of Artemisia annua on aortic rings in diabetic rats is an endothelium-dependent effect and acts through production and release of NO. Moreover it exerts its protective effect via inhibition of Ca2+ release from intracellular stores. Aorta Artemisia Annua Calcium Diabetes Mellitus Nitric Oxide Phenylephrine 2007 3 01 32 38 http://sjh.umsha.ac.ir/article-1-458-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Effect of Dexamethasone on Postoperative Vomiting and Oral Intake after Adenotonsillectomy Mohammad Reza Fazel fazel48@yahoo.com Ahmad Yegane Moghaddam Zahra Forgani Farhad Farahani Introduction & Objective: Complications of adenotonsillectomy such as pain, nausea and vomiting, fever, inadequate oral intake, dehydration and bleeding are common and important. In addition of unpleasant feeling for patient, post operative nausea and vomiting will lead to more prolonged hospitalization and intravenous hydration. The purpose of this study was to determine whether a single dose of dexamethasone (0.5mg/kg) administered before surgery could decrease postoperative vomiting and improves oral intake in the first 24-hours after adenotonsillectomy procedures. Materials & Methods: In this double-blinded, placebo controlled study, 100 patients age 5-15 years, with ASA physical status I and II were enrolled and they were randomly allocated to receive either dexamethasone (n=50) 0.5 mg/kg IV (maximum dose 8 mg) or an equivalent volume of saline (n=50) preoperatively. The anesthetic regimen and surgical procedures were standardized for all patients. The incidence of early and late vomiting, the first time oral intake, oral intake adequacy, and duration of IV hydration were compared in both groups.   Results: Data from 100 patients were analyzed. The overall incidence of early as well as late vomiting was significantly less in dexamethasone as compared to control group (P=0.001). The time to first oral intake, oral intake adequacy, and duration of IV hydration showed significant difference in both groups (P=0.01). Conclusion: A single dose of dexamethasone was not associated with adverse effects. Dexamethasone significantly decreased the incidence of postoperative vomiting during the first 24 hour, shortened the time to the first oral intake, oral intake adequacy, and duration of IV hydration. Adenoids Dexamethasone Tonsillectomy Vomiting 2007 3 01 39 42 http://sjh.umsha.ac.ir/article-1-459-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Survey of the Effective Methods of Decreasing Demands of Narcotic Substances from the Viewpoint of Hamadan People Ali Reza Rahimi Ali Ghaleiha Farshid Shamsaei shamsai68@yahoo.com Mohammad Kazem Zarabian Introduction & Objective: Addiction is a complex problem with different psychological, social and familial aspects, which strongly threaten the health of million people, and collapse the social and personal life. The aim of this study was to determine the effective methods of narcotic substances and decreasing demands from the viewpoint of Hamadan people Materials & Methods: This research was a sectional-descriptive study. The participants consisted of 1456 individuals that were selected by stratified sampling. The data collected through a questionnaire consists of 3 parts I. the demographic characteristics II. the questions about decreasing the demands and III. the questions related to the methods of narcotic substances campaign. Results: Outcome showed that 60.78% of the participants believe the best method to decrease demands to narcotic substances is the mass media and 51.92% believe to promote the religious believes and 44.5% to change people’s viewpoint about the narcotic substances. 78.85% agreed with using punishments on narcotics devisers and 40.1% agreed with punishment on users. Conclusion: From the viewpoint of Hamedan people mass media and religious believes effect in attitude of people about narcotic substances abuse and also they believed that punishment of users and opinion devisers were being useful. Attitude Education Narcotic Substances 2007 3 01 43 47 http://sjh.umsha.ac.ir/article-1-460-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Evaluation of Stress-Inducing Factors of Educational Environment in Hamadan Dentistry School’s Students Mohsen Dalband mohdalband@yahoo.com Abdollah Farhadi Nasab Introduction & Objective: The aim of this study was to evaluate stressor factors of educational environment in Hamadan dental school’s students in year 2002. Materials & Methods: The study design was descriptive, cross-sectional and it was accomplished using a questionnaire which was taken from DES (dental environment stress) questionnaire. According to restricted number of statistical population all members of population (154 students) were evaluated as samples and this study was a survey one.    Results: The results of this study indicated that most stressfull factors in dental students has been related to class work with mean score 3.18±0.83 and faculty-student relationship with mean score 3.05±0.83. Female students showed more total stress than male students (2.73 vs. 2.44). The fourth-year students had the most stress rate in all students of different years (3.05) and preclinical and clinical factors were the most stress-inducing factors of these students (3.63). Conclusion: It is concluded that the environment of Hamadan dental school and the process of education in the field of dentistry is potentially stressful. Also there is a reverse relationship between level of stress in students and their academic efficiencies. Education Stress Students Dental 2007 3 01 48 52 http://sjh.umsha.ac.ir/article-1-461-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Assessing the Adequacy of Dialysis in Patients under Hemodialysis in Dialysis Ward of Ekbatan Hospital of Hamadan Seyyed Reza Borzou edu1374@yahoo.com Mahmoud Gholyaf Roya Amini Mitra Zandieh Bita Torkaman Introduction & Objective: Cardiovascular diseases and inadequacy of dialysis are the leading causes of mortality and morbidity in the dialyzing patients. Improvement of the dialysis efficacy has important role in improving the patient’s prognosis. Aim of the current study was to determine the adequacy of dialysis in patients under hemodialysis in dialysis department of Ekbatan Hospital of Hamadan. Materials & Methods: The study was descriptive, cross-sectional. In this study forty two patients underlie dialysis were enrolled and evaluated. Variables, included the patient’s weight before and after dialysis, ultrafiltration, BUN before and after dialysis, the time of dialysis, speed of blood circulation, rate of filter clearance were recorded in a checklist. Computerized analysis of the data was performed and clearance rate of urea by dialysis Kt/V (daugirdas II) and URR were measured. Results: According to the obtained results 35.7% of patients have URR >65% that the results were in accord with standard scales, and revealed adequate dialysis. About 38.1% had URR near to accepted range (55%-65%). The rest of individuals i.e. about 25.1% had URR lower than accepted range. Results obtained from Kt/v calculation showed that 26.2% of individuals had Kt/v between 1.21 and 1.7, that the results were in accord with standard scales, and revealed adequate dialysis. About 50% were near accepted range (0.9-1.2). The rest of individuals about 23.8% had Kt/v<0.9. Conclusion: This study suggests that the dialysis in Ekbatan hemodialysis center have near standard adequacy (URR,Kt/v). Dialysis Adequacy Hemodialysis Kidney Failure Chronic 2007 3 01 53 57 http://sjh.umsha.ac.ir/article-1-462-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Epidemiologic Survey of Suicide Attempters Hospitalized in Hamadan Sina Hospital in 2001-2002 Ali Ghaleiha Ghaleihaali@yahoo.co.uk Fatemeh Behroozi Fard Introduction & Objective: Suicide is the most basic urgency of psychiatry and one of the greatest problems of human. Awareness of epidemiologic factors can help to predict it. The marital status, age, sex and socio-economical and geophysical factors such as time (day, week …) can influence it.  The recognition of these factors lets us to realize preventative methods and decrease suicide. Therefore, this study was implemented to achieve these goals. Materials and Methods: The current survey was a descriptive cross-sectional.  The studied population was suicide attempters that hospitalized in Hamadan Sina Hospital from August 2001-2002. The sample population (N=400) were chosen randomly out of 1108 suicide performers hospitalized during this period. Required data included demographic and suicide attempters’ spatial-temporal features, extracted from their history records and entered into computer. The data were statistically analyzed by SPSS v.10 using X2 test. Results: The current study showed that the ratio of men (52%) who attempted suicide was more than that of women. The group age of 15-25 years had the most frequency in suicide attempters (63.7%), the single persons included 50.5 % of suicide attempters and housewives were 29.75% of cases. 80% of attempters were from urban areas. The greatest ratio of suicide related to time was 17% in August, and 15.75 % on Thursdays. While 33.75 % attempted suicide at night, more than any other times of the day. The least attempting of suicide occurred in Ramadan (3.75%), second was of Norouz (New Year) (4 %). There was no increase in suicide attempting during the perfect moon. Conclusion: The present study showed that suicide attempters were remarkable among youth and housewives and preventative affairs can include the investigation of these groups;#39 problems. Suicide Suicide Attempt Time 2007 3 01 58 63 http://sjh.umsha.ac.ir/article-1-463-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 Evaluation of Frequency of Lymphoma at the Teaching Hospitals of Hamadan City during 1993-2003 Hamid Abdolsamadi Abdolsamadi@umsha.ac.ir Pejman Bakianian Vaziri Introduction & Objective: The lymphomas are a group of malignant solid tumors that involving cells of the lymphoreticular or immune system. While primary symptoms of lymphoma could involve head and neck region thus have significant value for dentists. The aim of this study was evaluation of the frequency and epidemiologic data of Lymphoma in Hamadan. Materials & Methods: In this retrospective study, all documented files of malignancies in four teaching hospitals of Hamadan (Mobasher, Sina, Ekbatan, Imam Khomeini) during 1993-2003 were evaluated. Results: Through 350000 hospital files and 3500 cases of malignancies, 404 cases were Lymphomas. (11/5%) [285 Non-Hodgkin Lymphoma (NHL), 111 Hodgkin diseases (HD), 8 Burkitt Lymphoma (BL)]. Males had a higher incidence of types of Lymphoma (male – to female ratio was 1.6:1). The most common presentation of head and neck in all groups of the Lymphomas was cervical lymphadenopathy and the most common nodes were submandibular and superior cervical nodules. Conclusion: In this study the frequency of NHL was higher than HD and BL respectively that perhaps indicates affected to Lymphoma in all age groups. In this study, NHL was more common in patients older than age 40 years and BL most often in patients younger than 11 years of age. Lymphoma-epidemiology Malignancy 2007 3 01 64 68 http://sjh.umsha.ac.ir/article-1-465-en.pdf
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Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2007 13 4 A Case Report of Multiple Basal Cell Carcinoma Syndrome Akram Ansar ansar@umsha.ac.ir Mahmoud Farshchian Morteza Fereydoonnejad Introduction: Nevoid BCC syndrome (Gorline syndrome) is a familial disorder with autosomal dominant inheritense. This syndrome is combination of multiple BCC that occurs at an early age, characteristic faces with: frontal bossing, broad nasal bridge and hypertelorism, jaw cysts, palmoplanter pitting, macrocephaly, skeletal and spinal anomalies include bifid ribes, cervical rib and kyphoscoliosis, CNS abnormality include corpus callusom disgenesia , falx cerebri calcification(at early age) and mental deficiency. Case Report: This case was a 25-years-old female presented with multiple and progressive skin lesions with different size in neck, upper trunk and axilla (multiple BCC), palmoplantar pitting, jaw cyst, cervical rib, bifid rib and liver haemangioma. Conclusion: With combination of clinical feature, histopathological reports of skin lesions and radiological reports of mandibular cyst and ribs anomalies, this case was diagnosed as nevoid BCC syndrome. Basal Cell Nevus Syndrome Gorline Syndrome Palmoplantar Pitting 2007 3 01 69 71 http://sjh.umsha.ac.ir/article-1-466-en.pdf