2024-03-28T14:32:15+03:30 http://sjh.umsha.ac.ir/browse.php?mag_id=85&slc_lang=fa&sid=1
85-1377 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Echocardiographic Evaluation of Indices of Right Ventricle Dysfunction in Pulmonary Hypertension Sh Homayounfar shahram1338@gmail.com N Khansari F Fariba Introduction: Echocardiography is usually the first modalities of imaging to evaluate the structural and functional disorders of the heart and great vessels, and colored flow and Doppler images are able to perform hemodynamic and bloodstream evaluations. The goal of this study was the investigation of right ventricular function using echocardiography in patients with pulmonary artery hypertension. Methods: In this cross-sectional study, the study population included all the patients with pulmonary artery hypertension for any reason, and their diagnoses using echocardiography and measurement of pulmonary artery pressure were confirmed, which were higher than 25. The number of samples was 80 and patients underwent echocardiography with two-dimensional and tissue doppler imaging. Data were analyzed using SPSS software version 16 and Chi-squared test, Pearson’s correlation coefficient and t-test. The significance level was considered less than 0.05. Results: The results of statistical tests showed that the means of FAC, TAPSE, and TIE indexes in the group with PVR less than 2 were significantly higher than the means of FAC (P = 0.006), TAPSE (P = 0.04), and TIE (P = 0.01) indexes in the group with more PVR, and were equal to 2 in this study. Also, the differences between the mean of normal and abnormal values of FAC, SWAVE, and TIE indexes in patients with normal PVR were not significant, while these differences were significant in patients with abnormal PVRs. Conclusion: In echocardiography investigations of right ventricular function in patients with pulmonary artery hypertension, the values obtained from FAC, SWAVE and TIE indexes and TAPSE had high diagnostic confidences in these patients. Therefore, these items were disturbed as a result of increase in the degree of resistance of pulmonary bed, and were good criteria to evaluate the right ventricular function in these patients. In the meantime, FAC values were more sensitive to the abnormal values of PVR due to the high frequency of its abnormal values in the range of abnormal PVR, and it was a good criterion to evaluate the right ventricular function in patients with pulmonary artery hypertension. Two Dimensional Echocardiography Doppler Echocardiography Right Ventricle Pulmonary Artery Hypertension 2017 3 01 281 287 http://sjh.umsha.ac.ir/article-1-1377-en.pdf 10.21859/hums-23045
85-1378 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Effct of Topical Vancomycin on Eradication of Staphylococcus aureus in Sinonasal Polyposis Aftr Functional Endoscopic Sinus Surgery J Jahanshahi jahanshahi287@gmail.com D Yazdani Introduction: One of the main theories in development of sinonasal polyposis involves the effect of Staphylococcus aureus super antigens and microbial biofilm. The aim of this study was to evaluate the effect of topical vancomycin on Staphylococcus aureus removal from sinus mucosa following surgery. Methods: In this randomized triple-blind clinical trial, 35 patients, who underwent sinus polyp surgery and whose sinus culture was positive for Staphylococcus aureus before surgery, were divided to two groups. For the case group, nasal irrigation with normal saline solution containing vancomycin and for the control group, nasal irrigation with normal saline solution was administered for eight weeks. During the second month of treatment, all patients underwent nasal endoscopy. Patients were assessed for Staphylococcus aureus culture during the second month. All data were analyzed using two independent samples t-test and Fisher's exact tests. The level of statistical significance was considered as P < 0.05. Results: Culture of Staphylococcus aureus in the second month was significantly lower in the case group than the control one (P < 0.05). Conclusion: It seems that the use of topical vancomycin solution has an effect on eradication of Staphylococcus aureus in sinonasal polyposis after surgery Polyps Nasal Sinuses Staphylococcus aureus Vancomycin 2017 3 01 288 292 http://sjh.umsha.ac.ir/article-1-1378-en.pdf 10.21859/hums-23041
85-1379 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Factors Delaying Hospital Arrival Aftr Acute Stroke Onset M Ghiasian Sh Mazaheri dr_sh_mazaheri@yahoo.com F Hashemi Rahbarian Introduction: Optimal time of referral after stroke and the use of new therapies, such as r-tPA and blood pressure control, could accelerate symptoms recovery after stroke. The aim of this study was to investigate factors contributing to the delay in referral to hospitals after the occurrence of acute stroke. Methods: This analytic-descriptive study included 425 patients, who had referred to the Hamadan Farshchian hospital during years 2015 and 2016. Demographic data, time of referring to medical center, the time of occurrence of stroke, risk factors, clinical symptoms of stroke, way of referring, distance from medical center and type of stroke by using a questionnaire and checklist were recorded. The SPSS (version 16) software was used for all calculations. Results: The mean age of patients in this study was 70.12 years old. Overall, 260 patients (61.2%) were male and 85.6% had ischemic stroke. Mean time of referral to first treatment center and Farshchian hospital was 2.06 and 4.77 hours, respectively. A total of 36.2% patients arrived to Farshchian hospital, within less than 2 hours. Factors that prolonged time to presentation were male gender, ischemic stroke, low education, being at a location far from the medical center, referral from other medical centers, being single, having no witness during stroke, and having a stroke at home, and during night. The most common symptoms in patients who were referred within less than two hours were confusion and loss of consciousness with frequency of 29.2%. The most common risk factor in 61.4% of patients, who were referred within less than 2 hours, was high blood pressure. Conclusion: This study showed mean time of referral for treatment after stroke was high. Influential elements that could possibly delay hospital arrival include, being at a location far from the medical center, no adequate knowledge about stroke symptom, having stroke at night, not referring directly to the medical center, being single, and no witness during stroke. . Acute Stroke Emergency Care Pre-Hospital Delay 2017 3 01 293 299 http://sjh.umsha.ac.ir/article-1-1379-en.pdf 10.21859/hums-23043
85-1380 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Comparative Study of Thrapeutic Effcts of%20 Azelaic Acid and %4 Hydroquinone Cream in Treatment of Melasma M Bahadori dr.bahadori1360@gmail.com G Eshghi L Khezrian MA Seifrabiei Introduction: Melasma is a recurrent, symmetric, and chronic acquired hyperpimentation that presents gray-brown macules and patches with determined margins in areas exposed to light. There are many treatment options with different efficacies and side effects. In this study the therapeutic effect of 20% azelaic acid and 4% hydroquinone in treatment of melasma was assessed. Methods: In this clinical trial, the study population consisted of all patients with clinical diagnosis of melasma, who referred to the outpatient clinic of dermatology of Hamadan, Farshchian Hospital from December 2013 to July 2014. A total of 44 patients were recruited. Patients were randomly divided to two groups and each group was treated with either azelaic acid or hydroquinone for four months. The MASI score was used to evaluate the improvement. P values of ≤ 0.05 were considered significant. Results: Of 44 patients, 21 received 4% hydroquinone and 23 received 20% azelaic acid, with random allocation. Both groups were similar with respect to gender and age, and there were no significant differences between the two groups. The MASI score in both groups had a decreasing trend over time, and at the end of the fourth month, a significant difference was found between the two groups (P = 0.006). The overall mean MASI score in both groups had a significant difference at different times and during the entire trial period, mean MASI score of 20% azelaic acid was lower than 4% hydroquinone (P = 0.001). Conclusion: Based on this study, we could conclude that 20% azelaic acid in comparison with 4% hydroquinone had better effects on treatment of melasma. Therefore, 20% azelaic acid is a good alternative for 4% hydroquinone in treatment of melasma. Azelaic Acid Hydroquinone Melasma 2017 3 01 300 305 http://sjh.umsha.ac.ir/article-1-1380-en.pdf 10.21859/hums-230411
85-1381 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 The Effct of Silver Nano-Particles on Removing Klebsiella pneumoniae from Industrial Residues R Habibipour habibipour@iauh.ac.ir M Sadeghian A Seif S Bayat Introduction: Progress in nano-science and nanotechnology in the past decade has provided many opportunities to study the biological effects of nanoparticles, in particular their anti-bacterial effects. The aim of this study was to evaluate the antimicrobial properties of silver nanoparticles for the removal of Klebsiella pneumoniae isolated from industrial effluents. Methods: In this experimental study, after sampling polluted industries, coliform and total coliform measurements of fecal industrial wastewater microbiology were performed by standard methods. The antimicrobial activity of silver nanoparticles on the bacteria (Klebsiella pneumoniae isolates and standard) was evaluated with the agar dilution method and broth dilution. One milliliter suspension containing bacteria at 1.5 × 108 CFU/mL was added to each sample followed by incubation at 37°C for 24 hours. After the mentioned period, the optical density at a wavelength of 600 nm was used to measure the concentration of bacteria. Next, 100 mL of each dilution was transferred to solid medium followed by incubation. The results were analyzed with SPSS 22 software. Results: Fecal and total coliform bacteria pollution of textile wastewater was approved, and Klebsiella pneumoniae (textile industry pollution index) were isolated. With increasing concentration, the antibacterial activity of silver nanoparticles increased while the number of colonies decreased. Although none of the concentrations were able to eliminate the bacteria, a non-significant decrease in the number of bacteria was observed. Conclusion: The results of the study showed that the type of bacteria and concentrations of silver nanoparticles antimicrobial properties of silver nanoparticles are risk factors. Although the concentrations used were effective against bacteria yet they did not lead to complete elimination of bacteria Therefore potential impact of nanoparticles for use requires further research and economic factors and other factors should be considered in their application. Klebsiella pneumoniae Nanoparticles Silver 2017 3 01 306 313 http://sjh.umsha.ac.ir/article-1-1381-en.pdf 10.21859/hums-23046
85-1382 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Estimation of Diseases and Mortality Attibuted to Atmospheric NO2 and SO2 Using AirQ Model in Hamadan City, Iran M Leili F Bahrami Asl Farshadfb@gmail.com M Hesam M Molamahmoudi S Salahshour Arian Introduction: NO2 and SO2 as gaseous air pollutants are involved in many global air accidents, and are respiratory tract irritants that can cause numerous health effects in humans. Therefore, due to the necessity of studies in this field and the absence of any similar study in the city of Hamadan, the aim of this study was quantification of health effects attributed to NO2 and SO2 in Hamadan city of Iran during years 2014 and 2015. Methods: This was a cross-sectional study. Primarily, required criteria pollutants and meteorological data were obtained from the environmental protection agency and meteorological agency of Hamadan city, respectively. The obtained data were validated using the World Health Organization (WHO) criteria. Required statistical indices were calculated and according to baseline incidence, relative risk and exposed populations, the different effects of pollutants were assessed. Results: According to the results, the average annual concentration of NO2 and SO2 was 1.7 and 1.6 times more than the standard, respectively. With central relative risk, the estimated attributed portion for total mortality attributed to NO2 and SO2 was 1.74 and 0.92, respectively, which is equal to death of 51.9 and 27.3 individuals during years 2014 and 2015, respectively. Conclusion: As a result, it should be stated that most of the adverse health effects attributed to SO2 and NO2 were observed in concentration ranges from 20 to 49 and 40 to 89 micrograms per cubic meter, respectively. This indicated that the concentration distribution of NO2 was wider than SO2. It can also be concluded that investigated pollutants (NO2 and SO2) had significant adverse effects on the residents of Hamadan city and before further increase in the effects, preventive measures should be taken by relevant authorities Air Pollution Health Effct Nitrogen Dioxide Sulfur Dioxide 2017 3 01 314 322 http://sjh.umsha.ac.ir/article-1-1382-en.pdf 10.21859/hums-230412
85-1383 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Evaluation of Research Outputs at the Hamadan University of Medical Sciences Based on the Hirsch Index and m Parameter: A Scientometric Study Masoud Koorki Alireza Isfandyari –Moghaddam ali.isfandyari@gmail.com Behrooz Bayat Introduction: One of the most important evaluation methods for scientific outputs of researchers and research centers is to use the Hirsch index (h-index) and m parameter. The main advantages of these indicators are simultaneous evaluation of the quantitative and qualitative of scientific production. The aim of this study was to determine the research outcomes of the faculty members of Hamadan University of Medical Sciences based on the Hirsch index and m parameter indexed in Google Scholar until end of 2016. Methods: In this scientometric and descriptive study all of the faculty members of Hamadan University of Medical Sciences (425 people) were included in the census method. With a direct view Google Scholar database and insertions of affiliation for university the Hirsch index and scientific age of people were extracted and then documented the checklist, as a result those m parameter were calculated. In the final operations and in order to data analysis software, so data analysis was carried out by software SPSS16, as well as a number of indicators and charts and graphs, descriptive statistics were used. Results: Of the total, 209 people (49.2%) have the Hirsch index. The overall mean (SD) of the Hirsch index 2.71(3.85) and m parameter 0.36 (0.44) were obtained, respectively. The maximum Hirsch index has been 17 that three members of the biochemistry, biostatistics and epidemiology and public health they earn them, respectively, and the highest m parameter was 2.16 that was awarded to the academic member of Psychiatry department. The mean of the Hirsch index and m parameter were 3.31 and 0.42 in men and 1.76 and 0.25 in women respectively, as well as for the basic sciences courses 4.97 and 0.57 and also for clinical sciences 1.72 and 0.26 were obtained. Ph.D. degree and professor grade, respectively with Hirsch index 5.01 and 9.3 and m parameter 0.58 and 0.89 were highest mean as well. In terms of scale between the two indexes studied, rank and position of all four variables did not differ. In general, department of immunology at the university, the mean of Hirsch index 9.25 and department of biostatistics and epidemiology the mean of m parameter 1.14 were top rank respectively. School of health the mean of the Hirsch index 7.02 and the mean of m parameter 0.87 has been the highest rating from two aspects among the universities obtained. In comparison between the two indices of scientometric, ranking and position of other faculties and educational departments were different from together. Conclusion: The average of the Hirsch index and m parameter of research products at the faculty members of Hamadan University of Medical Sciences, between the universities of medical sciences will be assessed average to high level and fairly good, but they are low level than international indices both qualitatively and quantitatively aspects. Hence, it is recommended that of the m parameter to be used accompanying with other scientometric indices as scientific evaluation criteria of academic researchers. Faculty Member Google Scholar Research Output Scientometric 2017 3 01 323 335 http://sjh.umsha.ac.ir/article-1-1383-en.pdf 10.21859/hums-23047
85-1384 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Determination of Drug Susceptibility of Candida Strains Isolated From Patients With Recurrent Candida Vulvovaginitis and Investigation of Predisposing Factors of the Disease MH Minooeianhaghighi M Sehatpour H Shokri hshokri@ausmt.ac.ir Introduction: Recurrent Vulvovaginal Candidiasis (RVVC), which is mostly caused by Candida albicans (C. albicans), is the second common cause of genital tract infection in females. The purpose of this research was to identify Candida isolates from RVVC, identify predisposing factors and determine antifungal effect of fluconazole against Candida strains isolated from the patients. Methods: In this descriptive-laboratory study, 20 patients with confirmed diagnosis of RVVC were selected. Yeast isolates were characterized using mycological standard methods, including culture on Sabouraud dextrose agar medium and CHROM agar, germ tube test and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The susceptibility of Candida isolates against fluconazole was determined by microdilution broth method. Results: The average age of the patients was 29.43 ± 4.63 years. Candida albicans was obtained from 100% of the samples. The most common clinical sign was vaginal discharge (60%) in females with positive culture. Statistical correlations were observed between parturition frequency and low RVVC occurrence as well as between the previous antifungal therapy and RVVC occurrence. The mean minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of fluconazole against different C. albicans strains was determined as 45.3863 µg/mL and 63 µg/mL, respectively. Conclusion: Due to the uncertainty of diagnosis of this disease according to clinical symptoms and also, due to the resistance of Candida species, using culture and molecular methods are recommended as standard methods of diagnosis. Vulvovaginal Candidiasis Candida albicans Polymerase Chain Reaction Vaginal Discharge Fluconazole 2017 3 01 336 344 http://sjh.umsha.ac.ir/article-1-1384-en.pdf 10.21859/hums-23042
85-1385 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Comparison of the Therapeutic Effects of Silymarin and Nanosilymarin on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles A Hajizadeh Moghaddam a.hajizadeh@umz.ac.ir E Ahmadi Avendi R Sayraf M Zare Introduction: Recent studies have indicated that titanium dioxide nanoparticles (TiO2 NPs) are toxic for human. Silymarin is a well-known hepatoprotective drug. In this study, the nanoprecipitation technique was used for nanocrystals to improve the solubility of silymarin. The aim of this study was to analyze the protective role of silymarin and its nanocrystal on liver damage due to TiO2 NPs in rat. Methods: In this experimental study, rats were divided to five groups in separate cages: Control, vehicle, toxic group (150 mg/kg TiO2 NPs for three weeks orally) as well as silymarin and silymarin NPs groups (100 mg/kg for three weeks orally after TiO2 NPs administration). Then, the serum level of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) as well as the liver histological changes were investigated. Results: Oral administration of Tio2 NPs resulted in significantly elevated levels of ALT, AST and ALP of serum and significantly increased the core diameter of hepatocytes (P < 0.05). Silymarin and its nanocrystal reduced the elevated liver enzyme levels and also decreased the core diameter of hepatocytes in toxic rats (P < 0.001). Conclusion: : The results from the present study indicated that silymarin and its nanocrystal probably due to antioxidant effects cause hepatoprotective against TiO2 NPs-induced liver injury.       Titanium Dioxide Nanoparticles Silymarin Nanocrystal Liver Enzymes 2017 3 01 345 351 http://sjh.umsha.ac.ir/article-1-1385-en.pdf 10.21859/hums-23048
85-1386 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 In vitro Evaluation of the Effect of Bacterial Extract, Isolated From Infected Hydatid Cysts, on Protoscolex M Sardari A Maghsood M Y Alikhani M Fallah Fallah@umsha.ac.ir Introduction: To date, surgery has been the treatment of choice for hydatid cyst, with regard to danger of leakage of hydatid cyst contents into viscera and production of secondary cysts, after spread of protoscolices. Different scolicidal agents get injected into cyst for preventing the secondary cyst production, which may cause different side effects in host, especially in the surrounding tissues. In this research, the scolicidal effects of bacterial extract isolated from infected hydatid cyst was evaluated. Methods: In this experimental-laboratorial study, at first, isolation and identification of the infecting bacteria of hydatid cyst were performed at the level of species. Then, total the bacterial extract was prepared by sonication method, and serial dilutions (1.1, 1.2, 1.4, 1.8, 1.16, 1.32 and 1.64) were prepared using sterile saline as the solvent. The obtained alive larvae at the times of 5, 10, 20, 40 and 60 minutes were placed in those dilutions and mean of dead protoscoleces were determined using eosin exclusive staining method. Results: The identified bacteria isolated from the infected hydatid cysts were as follows: E. coli, Staphylococcus aureus, S. saprophyticus, Proteus mirabilis and Pseudomonas aeruginosa. The extract of isolated bacteria at the mentioned times had no considerable scolicidal effects. For example, the whole extract of P. aeruginosa after 60 minutes of exposure showed a maximum of 13.17%. scolicidal effect. Conclusion: The results of this study showed low scolicidal effect of bacterial extracts isolated from hydatid cyst. Degeneration of scolices in infected cysts can be due to other reasons than bacterial extract. Bacterial Extract Hydatid Cyst Protoscolex Scolicidal Sonication 2017 3 01 352 359 http://sjh.umsha.ac.ir/article-1-1386-en.pdf 10.21859/hums-23044
85-1387 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 Comparison of Dissolved Air Flotation Process for Aniline and Penicillin G Removal From Aqueous Solutions F Kord Mostafapoor Sh Ahmadi sh.ahmadi398@gmail.com D Balarak S Rahdar Introduction: The presence of antibiotics due to toxicity and sustainability as well as organic compounds as a combination of hard biodegradable wastewater is an undesirable issue in many industries. The aim of this study was to evaluate the efficiency of dissolved air flotation process for aniline and penicillin G removal from aqueous solutions. Methods: This was an empirical-lab study to which the dissolved air flotation method was applied in laboratory scale. The effects of effective parameters including concentration of coagulant poly-aluminum chloride (PAC) (10, 20, 30, 40, 60 mg/L), coagulation time (5, 10, 15 and 20 minutes), flotation time (5, 10, 15 and 20 seconds) and saturation pressure (3, 3.5, 4 and 4, 5 atm) on the removal efficiency of aniline and penicillin G by dissolve air flotation were studied. Results: The results showed that dissolved air flotation method can reduce penicillin G and aniline up to 67.45% and 95%, respectively. The optimum condition was as follows: pH = 6, initial concentration of aniline = 200 mg/L, initial concentration of penicillin G = 25 mg/L, coagulation time = 10 minutes, flotation time = 10 seconds, pressure = 4 atm, and PAC concentration = 20 mg/L. Conclusions: Dissolved air flotation process can be an effective method to remove aniline and penicillin G from aqueous solutions. Dissolved Air Flotation Aqueous Solution Aniline Penicillin G 2017 3 01 360 369 http://sjh.umsha.ac.ir/article-1-1387-en.pdf 10.21859/hums-230410
85-1388 2024-03-28 10.1002
Avicenna Journal of Clinical Medicine Avicenna J Clin Med 2588-722X 2588-7238 10.52547/ajcm 2017 23 4 A Case Report of Parry-Romberg Syndrome P Alirezaei L Khezrian khezrian.leila@yahoo.com H Ghasemi Basir S Khanali Introduction: Parry-Romberg syndrome, a rare syndrome, is characterized by progressive atrophy affecting one side of the face. This disease can include the skin, subcutaneous tissue, muscles, cartilage, and underlying bony structures. Case Presentation: A 27-year-old female was admitted to the outpatient clinic of dermatology of Farshchian Hospital, with chief complaint of asymmetric facial appearance. The asymmetry started at the age of 16 and developed over a period of 4 years, then stopped. A physical examination revealed that the right side of her face, especially her chin was smaller than the left side, and there was loss of subcutaneous fat, which was associated with skin tightness. There were no systemic symptoms of other illnesses or other signs. Conclusion: The disease is self-limiting, yet, can be associated with systemic involvement such as neurological disorders. Clinical symptoms are the keys of diagnosis. A muli-lateral approach is essential to control the disease. Asymmetry Parry-Romberg Syndrome Face 2017 3 01 370 373 http://sjh.umsha.ac.ir/article-1-1388-en.pdf 10.21859/hums-23049