Volume 28, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2021)                   Avicenna J Clin Med 2021, 28(1): 20-27 | Back to browse issues page

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Sobhan M, Khanlarzadeh E, Moradi Rozbhani M. Correlation between Vitamin D Deficiency and Seborrheic Dermatitis in Patients Referred to the Dermatology Clinic of Sina Hospital, Hamadan, Iran. Avicenna J Clin Med 2021; 28 (1) :20-27
URL: http://sjh.umsha.ac.ir/article-1-2199-en.html
Correlation between Vitamin D Deficiency and Seborrheic Dermatitis in Patients Referred to the Dermatology Clinic of Sina Hospital, Hamadan, Iran
Mohammadreza Sobhan 1, Elham Khanlarzadeh2 , Mahrokh Moradi Rozbhani3
1- Assistant Professor, Department of Dermatology, School of Medicine, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , mreza_sobhan@yahoo.com
2- Assistant Professor, Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamedan, Iran
3- General Practitioner, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (4920 Views)
Background and Objective: Seborrheic dermatitis is one of the most common inflammatory skin diseases that affect the sebaceous glands. Although the exact role of vitamin D in this disease is still not clearly understood, some studies have shown lower serum levels of vitamin D in seborrheic dermatitis patients. This study aimed to investigate the correlation between vitamin D deficiency and seborrheic dermatitis. 
Materials and Methods: This cross-sectional case-control study was conducted in Sina Hospital, Hamadan, Iran. The study sample included 39 seborrheic dermatitis patients (case group) and 39 healthy individuals (control group) who were matched in terms of gender and age. The groups were then compared regarding serum vitamin D level. Statistical analysis was performed in SPSS software (version 16.0; SPSS Inc.Chicago, IL).
Results: There were no significant differences between the two groups in terms of age, gender, educational level, place of residence, and occupational status. The mean serum levels of vitamin D in the case and control groups were 11.82±5.56 and 21.38±6.79ng/ml, respectively (P=0.001). Furthermore, in the case and control groups, 18 (46.2%) and 1 (2.6%) individuals had vitamin D deficiency; 20 (51.3%) and 34 (87.2%) cases had inadequate vitamin D levels; and 1(2.6%) and 4 (10.3%) subjects had adequate levels of vitamin D, respectively. Therefore, the serum level of vitamin D was significantly lower in the case group, compared to the control group (P=0.001). Moreover, the serum level of vitamin D did not correlate with the duration and severity of seborrheic dermatitis disease (P>0.05).
Conclusion: According to the findings of this study, patients with seborrheic dermatitis had lower serum vitamin D levels, compared to the general population, which may be related to the pathogenicity of the disease.
 
 
Keywords: Seborrheic Dermatitis, Severity of Disease, Vitamin D
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Type of Study: Original | Subject: Dermatology
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References
1. Sampaio AL, Mameri AC, Vargas TJ, Ramos-e-Silva M, Nunes AP, Carneiro SC. Seborrheic dermatitis. An Bras Dermatol. 2011;86(6):1061-71. PMID: 22281892 DOI: 10.1590/s0365-05962011000600002
2. Ijaz N, Fitzgerald D. Seborrhoeic dermatitis. Br J Hosp Med (Lond). 2017;78(6):C88-91. PMID: 28614013 DOI: 10.12968/hmed.2017.78.6.C88
3. Quéreux G. Dermatitis seborreica. EMC Dermatol. 2019;53(1):1-9. DOI: 10.1016/S1761-2896(19)41715-9
4. Castillo DE, Gunczler I, França K, Keri J. Seborrheic dermatitis. Adv Integr Dermatol. 2019;71:552. DOI: 10.1002/9781119476009
5. Ooi ET, Tidman MJ. Improving the management of seborrhoeic dermatitis. Practitioner. 2014;258(1768):23-6. PMID: 24689165.
6. Prohic A, Kasumagic-Halilovic E. Identification of Malassezia species from immunocompetent and immunoco-mpromised patients with seborrheic dermatitis. Eur Rev Med Pharmacol Sci. 2010;14(12):1019-23. PMID: 21375133
7. Zani MB, Soares RC, Arruda AC, de Arruda LH, Paulino LC. Ketoconazole does not decrease fungal amount in patients with seborrhoeic dermatitis. Br J Dermatol. 2016;175(2):417-21. PMID: 26920094 DOI:10.1111/bjd.14501
8. Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013;31(4):343-51. PMID: 23806151 DOI: 10.1016/j.clindermatol.2013.01.001
9. Gupta A, Bluhm R, Cooper EA, Summerbell RC, Batra R. Seborrheic dermatitis. Dermatol Clin. 2003;21(3):401-12. PMID: 12956195 DOI: 10.1016/s0733-8635(03)00028-7
10. Sobhan M, Nazari F, Mohammadi Y. Correlation between seborrheic dermatitis and metabolic syndrome in patients referred to sina hospital of Hamadan. Avicenna J Clin Med. 2020;27(1):13-20. DOI: 10.29252/ajcm.27.1.13
11. Žmitek K, Hribar M, Hristov H, Pravst I. Efficiency of Vitamin D supplementation in healthy adults is associated with body mass index and baseline serum 25-hydroxyvitamin D level. Nutrients. 2020;12(5):1268. PMID: 32365732 DOI: 10.3390/nu12051268
12. Karthaus N, van Spriel AB, Looman MWG, Chen S, Spilgies LM, Lieben L, et al. Vitamin D controls murine and human plasmacytoid dendritic cell function. J Invest Dermatol. 2014;134(5):1255-64. PMID: 24352045 DOI: 10.1038/jid.2013.501
13. Kramer C, Seltmann H, Seifert M, Tilgen W, Zouboulis CC, Reichrath J. Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol. 2009;113(1-2):9-16. PMID: 19027855 DOI: 10.1016/j.jsbmb.2008.10.010
14. Teichert A, Bikle DD. Regulation of keratinocyte differentiation by vitamin D and Its relationship to squamous cell carcinoma. In: Glick A, Waes C, editors. Signaling pathways in squamous cancer. New York: Springer; 2011. DOI: 10.1007/978-1-4419-7203-3_14
15. Sahota O. Understanding vitamin D deficiency. Age Ageing. 2014;43(5):589-91. PMID: 25074537 DOI: 10.1093/ageing/afu104
16. DeDea L. Understanding vitamin D formulations. JAAPA. 2013;26(10):10. PMID: 24201915 DOI: 10.1097/01.JAA.0000435258.26357.4c
17. Schnatz PF, Manson JE. Vitamin D and cardiovascular disease: an appraisal of the evidence. Clin Chem. 2014;60(4):600-9. PMID: 24193116 DOI: 10.1373/clinchem.2013.211037
18. Bouillon R, Norman AW, Lips P. Vitamin D deficiency. N Engl J Med. 2007;357(19):1980-1. PMID: 17989396 DOI: 10.1056/NEJMc072359
19. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81. PMID: 17634462 DOI: 10.1056/NEJMra070553
20. Reichrath J, Zouboulis CC, Vogt T, Holick MF. Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook. Rev Endocr Metab Disord. 2016;17(3):405-17. PMID: 27447175 DOI: 10.1007/s11154-016-9353-4
21. Bikle DD. Vitamin D regulated keratinocyte differentiation. J Cell Biochem. 2004;92(3):436-44. PMID: 15156556 DOI: 10.1002/jcb.20095
22. Leyssens C, Verlinden L, Verstuyf A. The future of vitamin D analogs. Front Physiol. 2014;5:122. PMID: 24772087 DOI: 10.3389/fphys.2014.00122
23. Umar M, Sastry K, S, Al Ali F, Al-Khulaifi M, Wang E, Chouchane A. Vitamin D and the pathophysiology of inflammatory skin diseases. Skin Pharmacol Physiol. 2018;31(2):74-86. PMID: 29306952 DOI: 10.1159/000485132
24. Micali G, Lacarrubba F, Tedeschi A, Drischk T. A new proposed severity score for seborrheic dermatitis, seborrheic dermatitis area and severity index (SEDASI). J Am Acad Dermatol. 2017;76(6):AB18. DOI: 10.1016/j.jaad.2017.04.088
25. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008;168(15):1629-37. PMID: 18695076 DOI: 10.1001/archinte.168.15.1629
26. Sampogna F, Linder D, Piaserico S, Altomare G, Bortune M, Calzavara-Pinton P, et al. Quality of life assessment of patients with scalp dermatitis using the Italian version of the Scalpdex. Acta Derm Venereol. 2014;94(4):411-4. PMID: 24287710 DOI: 10.2340/00015555-1731
27. Palamaras I, Kyriakis KP, Stavrianeas NG. Seborrheic dermatitis: lifetime detection rates. J Eur Acad Dermatol Venereol. 2012;26(4):524-6. PMID: 21521374 DOI: 10.1111/j.1468-3083.2011.04079.x
28. Sanders MGH, Pardo LM, Franco OH, Ginger RS, Nijsten T. Prevalence and determinants of seborrhoeic dermatitis in a middle-aged and elderly population: the Rotterdam Study. Br J Dermatol. 2018;178(1):148-53. PMID: 28856679 DOI: 10.1111/bjd.15908
29. Tucker D, Masood S. Seborrheic dermatitis. Treasure Island (FL): StatPearls Publishing; 2020. PMID: 31869171
30. Schmidt JA. Seborrheic dermatitis: a clinical practice snapshot. Nurse Pract. 2011;36(8):32-7. PMID: 21768832 DOI: 10.1097/01.NPR.0000399717.56736.1e
31. Menzinger S, Laffitte E. Seborrhoeic dermatitis: clinical manifestations and management. Rev Med Suisse. 2011;7(289):752-4. PMID: 21568097
32. Cicek D, Kandi B, Bakar S, Turgut D. Pimecrolimus 1% cream, methylprednisolone aceponate 0.1% cream and metronidazole 0.75% gel in the treatment of seborrhoeic dermatitis: a randomized clinical study. J Dermatolog Treat. 2009;20(6):344-9. PMID: 19954391 DOI: 10.3109/09546630802687349
33. Clark GW, Pope SM, Jaboori KA. Diagnosis and treatment of seborrheic dermatitis. Am Fam Physician. 2015;91(3):185-90. PMID: 25822272
34. Elgash M, Dlova N, Ogunleye T, Taylor SC. Seborrheic dermatitis in skin of color: clinical considerations. J Drugs Dermatol. 2019;18(1):24-7. PMID: 30681789
35. Borzutzky A, Camargo CA Jr. Role of vitamin D in the pathogenesis and treatment of atopic dermatitis. Expert Rev Clin Immunol. 2013;9(8):751-60. PMID: 23971753 DOI: 10.1586/1744666X.2013.816493
36. Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol. 2011;164(5):1078-82. PMID: 21087229 DOI: 10.1111/j.1365-2133.2010.10147.x
37. Camargo CA Jr, Ganmaa D, Sidbury R, Erdenedelger K, Radnaakhand N, Khandsuren B. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J Allergy Clin Immunol. 2014;134(4):831-5. PMID: 25282565 DOI: 10.1016/j.jaci.2014.08.002
38. Sánchez-Armendáriz K, García-Gil A, Romero CA, Contreras-Ruiz J, Karam-Orante M, Balcazar-Antonio D, et al. Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial. Int J Dermatol. 2018;57(12):1516-20. PMID: 30238557 DOI: 10.1111/ijd.14220
39. Dimitrova J. Study of the level of 25-hydroxyvitamin D in patients with seborrheic dermatitis. Scripta Sci Med. 2013;45(1):75-8. DOI: 10.18638/arsa.2016.5.1.826
40. Dimitrova J. The effect of vitamin D supplementation on recurrences of seborrheic dermatitis. Int J Curr Adv Res. 2017;6(3):2446-8. DOI: 10.24327/ijcar.2017.2448.0025
41. Ebrahimi M, Khashayar P, Keshtkar A, Etemad K, Dini M, Mohammadi Z, et al. Prevalence of vitamin D deficiency among Iranian adolescents. J Pediatr Endocrinol Metab. 2014;27(7-8):595-602. PMID: 24854533 DOI: 10.1515/jpem-2013-0428
42. Sepandi M, Esmailzadeh S, Hosseini MS, Hashemi SR, Abbaszadeh S, Alimohamadi Y, et al. Prevalence of vitamin D deficiency among Iranian pregnant women. Nutr Diet Supplements. 2020;12:97-102. DOI: 10.2147/NDS.S261229
43. Tabrizi R, Moosazadeh M, Akbari M, Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, et al. High Prevalence of vitamin D deficiency among Iranian population: a systematic review and meta-analysis. Iran J Med Sci. 2018;43(2):125-39. PMID: 29749981
44. Jazayeri M, Moradi Y, Rasti A, Nakhjavani M, Kamali M, Baradaran HR. Prevalence of vitamin D deficiency in healthy Iranian children: a systematic review and meta-analysis. Med J Islam Repub Iran. 2018;32(1):480-5. PMID: 30643758 DOI: 10.14196/mjiri.32.83
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