Sarcoidosis, a multysystem granulomatous disease, begin most frequently in people between 20 and 40 years old. The etiology is unknown, but alteration in the Immune system are clearly involved in its pathogenesis. Organ involvement is usually asymptomatic, and the disease most frequently regress spontaneously, but it may progress to a more chronic state of fibrosis with sever functional impairment of various organ.

We report two cases of sarcoidosis with different presentation, a 32 years old woman with acute sarcoidosis or loeffgren’s syndrome (pulmonary hilar enlargement, uveitis, peripheral arthitis, Erythema Nodosum), and a 47 years old man with eskletal involvement mainly.