Volume 26, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2019)                   Avicenna J Clin Med 2019, 26(2): 67-74 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alirezaei P, Jiryaee N, Shabbak A A. Comparison of Efficacy of Clotrimazole 1% Cream with Sertaconazole 2% Cream in Treatment of Adult Seborrheic Dermatitis. Avicenna J Clin Med 2019; 26 (2) :67-74
URL: http://sjh.umsha.ac.ir/article-1-1912-en.html
1- Assistant Professor, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , Prc@umsha.ac.ir
2- Assistant Professor, Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Resident, Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (262514 Views)
Background and Objective: Seborrheic dermatitis is a common inflammatory skin disease characterized by erythema, scaling, and pruritus. Antifungals are among the most commonly prescribed drugs for the treatment of this disease. In this regard, the present study investigated the efficacy of two medications including clotrimazole 1% and sertaconazole 2% in the treatment of adult seborrheic dermatitis.
Materials and Methods: This double-blinded randomized clinical trial was performed on 100 patients over the age of 18 with seborrheic dermatitis referring to Farshchian hospital, Hamadan, Iran. Patients were randomly assigned to two groups. The participants in one group received sertaconazole twice a day for four weeks and another group received clotrimazole within this period of time. After two weeks, the patients were examined in terms of clinical symptoms and side effects of medications. Moreover, they were reexamined for recurrence of disease after the completion of treatment and four weeks later. Furthermore, the level of patients' satisfaction was evaluated four weeks after treatment.
Results: Mean and standard deviation of Scoring Index 7.16±2.20 and 6.45±2.10 before treatment (P=0.184), 4.08 ± 1.82 and 2.78 ± 2.14 two weeks after treatment (P<0.001), and 2.62 ± 2.13 and 0.89 ± 1.09 four weeks after the end of treatment (P<0.001). Additionally, the relapse rate in clotrimazole and sertaconazole groups was found to be 32% and 21.7%, respectively. Furthermore, the complication rate was reported as 8% and 8.5% in clotrimazole group and sertaconazole group, respectively (P=0.220). Moreover, the rate of good satisfaction in clotrimazole and sertaconazole groups was reported as 38% and 71.1% (P<0.001), respectively.
Conclusion: Based on the results of the study, the frequency of complications and recurrence of disease in patients treated with sertaconazole was comparable to treatment with clotrimazole. However, sertoconazole was found to be more effective and bring more satisfaction to patients.
Full-Text [PDF 1122 kb]   (1924 Downloads)    
Type of Study: Original | Subject: Dermatology

1. Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. 3rd ed. Philadelphia: Elsevier; 2012.
2. Gary G. Optimizing treatment approaches in seborrheic dermatitis. J Clin Aesthet Dermatol. 2013;6(2):44-9. PMID: 23441240
3. Holden CA, Berth‐Jones J. Eczema, lichenification, prurigo and erythroderma. Rook's textbook of dermatology. 7th ed. New York: Blackwell Science; 2004.
4. Szepietowski JC, Reich A, Wesolowska-Szepietowska E, Baran E. Quality of life in patients suffering from seborrheic dermatitis: influence of age, gender and education level. Mycoses. 2009;52(4):357-63. PMID: 18793259 DOI: 10.1111/j.1439-0507.2008.01624.x
5. Tegner E. Seborrhoeic dermatitis of the face induced by PUVA treatment. Acta Derm Venereol. 1983;63(4):335-9. PMID: 6195866
6. Jean LB, Joseph LJ, Rapini RP, Thomas DH, Mascaro JM, Anthony JM. Dermatology. 2nd ed. Spain: Elsevier; 2008.
7. Dawson Jr TL. Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis. J Investig Dermatol Symp Proc. 2007;12(2):15-9. PMID: 18004291 DOI: 10.1038/sj.jidsymp.5650049
8. Dorn M, Rocehnert K. Dimorphism of Pityrosporum orbicular in a defind culture medium. J Invest Dermatol. 1977;62(2):244-8. PMID: 881572 DOI: 10.1111/1523-1747.ep12506384
9. Bikowski J. Facial seborrheic dermatitis: a report on current status and therapeutic horizons. J Drugs Dermatol. 2009;8(2):125-33. PMID: 19213227
10. Naldi L, Rebora A. Clinical practice. Seborrheic dermatitis. N Engl J Med. 2009;360(4):387-96. PMID: 19164189 DOI:10.1056/NEJMcp0806464
11. Ortonne JP, Nikkels AF, Reich K, Ponce Olivera RM, Lee JH, Kerrouche N, et al. Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomized, controlled study. Br J Dermatol. 2011;165(1):171-6. PMID: 21707573 DOI:10.1111/j.1365-2133.2011.10269.x
12. Nenoff P, Haustein UF. In vitro susceptibility testing of Malassezia furfur against rilopirox. Skin Pharmacol. 1997;10(5-6):275-80. PMID: 9449166
13. Okokon EO, Verbeek JH, Ruotsalainen JH, Ojo OA, Bakhoya VN. Topical antifungals for seborrhoeic dermatitis. Cochrane Database Syst Rev. 2015;5:CD008138. PMID: 25933684 DOI: 10.1002/14651858.CD008138.pub
14. Koca R, Altinyazar HC, Eştürk E. Is topical metronidazole effective in seborrheic dermatitis? A double-blind study. Int J Dermatol. 2003;42(8):632-5. PMID: 12890109 DOI: 10.1046/j.1365-4362.2003.01981.x
15. Goldust M, Rezaee E, Rouhani S. Double blind study of sertaconazole 2% cream vs. clotrimazole 1% cream in treatment of seborrheic dermatitis. Ann Parasitol. 2013;59(1):25-9. PMID: 23829055
16. Lotti T, Goldust M, Rezaee E. Treatment of seborrheic dermatitis, comparison of sertaconazole 2% cream versus ketoconazole 2% cream. J Dermatolog Treat. 2013;(4):703-6. PMID: 23441833 DOI: 10.3109/09546634.2013.777154
17. Attarzadeh Y, Asilian A, Shahmoradi Z, Adibi N. Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: a clinical trial. J Res Med Sci. 2013;18(6):477-81. PMID: 24250695
18. Goldust M, Rezaee E, Masoudnia S, Raghifar R. Clinical study of sertaconazole 2% cream vs. hydrocortisone 1% cream in the treatment of seborrheic dermatitis. Ann Parasitol. 2013;59(3):119-23. PMID: 24881281
19. Saki N, Jowkar F, Alyaseen S. Comparison of sertaconazole 2% cream versus hydrocortisone 1% ointment in the treatment of atopic dermatitis. J Dermatolog Treat. 2013;24(6):447-9. PMID: 23470235 DOI: 10.3109/09546634.2013.782384
20. Balighi K, Ghodsi SZ, Daneshpazhooh M, Ghale-Baghi S, Nasimi M, Azizpour A. Hydrocortisone 1% cream and sertaconazole 2% cream to treat facial seborrheic dermatitis: A double-blind, randomized clinical trial. Int J Womens Dermatol. 2017;3(2):107-10. PMID: 28560305 DOI: 10.1016/j.ijwd.2016.11.008
21. Rippon JW. Medical mycology; the pathogenic fungi and the pathogenic actinomycetes. 3rd ed. Philadelphia: Saunders; 1988. P. 155.

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb