Volume 26, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2020)                   Avicenna J Clin Med 2020, 26(4): 206-212 | Back to browse issues page

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1- , khazaeimojtaba@yahoo.com
Abstract:   (2487 Views)
Background and Objective: Stroke is the third most common cause of death in developed countries and the most common disabling neurological disease. There are several risk factors for stroke. Regarding this, the present study was conducted to investigate the effect of Helicobacter pylori antibody on the incidence of stroke.
Materials and Methods: This case-control study was conducted on 50 patients (i.e., case group) with stroke admitted to Sina Teaching Hospital of Hamadan, Iran, using convenience sampling method. This group was compared with 50 healthy controls in terms of the serum level of Helicobacter pylori antibody. The data were analyzed using SPSS software (version 21) using proper statistical tests at 95% confidence interval.
Results: The mean serum levels of Helicobacter pylori antibody in the case and control groups were 25.93±44.03 and 35.36±41.25 Uarb/ml, respectively (P=0.108). In addition, the serum levels of this antibody were obtained as 20.78 and 35.84 (P=0.055) in the females and 31.51 and 34.31 (P=0.501) in the males of the control and case groups, respectively. The Spearman correlation coefficient revealed a positive but insignificant relationship between age and serum antibody level of Helicobacter pylori in both groups (r=0.150; P=0.13).
Conclusion: As the findings indicated, the stroke patients had a lower serum level of Helicobacter pylori antibody, compared to the healthy non-stroke patients; however, this difference was not statistically significant.
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Type of Study: Original | Subject: Neurology

1. Menken M, Munsat TL, Toole JF. The global burden of disease study: implications for neurology. Arch Neurol. 2000;57(3):418-20. PMID: 10714674 DOI: 10.1001/archneur.57.3.418
2. Ropper AH, Samuels MA. Adams, Victor's principles of neurology. 10th ed. New York: McGraw-Hill; 2013.
3. Rowland LP, Pedley TA. Merritt’s neurology. 12th ed. Philadelphia: Lippincott Williams & Wilkins; 2010.
4. Zock E, Kerkhoff H, Kleyweg RP, van Bavel-Ta TB, Scott S, Kruyt ND, et al. Help seeking behavior and onset-to-alarm time in patients with acute stroke: sub-study of the preventive antibiotics in stroke study. BMC Neurol. 2016;16(1):241. PMID: 27884126 DOI: 10.1186/s12883-016-0749-2
5. Khalid W, Rozi S, Ali TS, Azam I, Mullen MT, Illyas S, et al. Quality of life after stroke in Pakistan. BMC Neurol. 2016;16(1):250. PMID: 27912744 DOI: 10.1186/s12883-016-0774-1
6. Guzman Sabogal YR, Pla Vidal J, Sanchez Pedraza R, Ortuno Sanchez-Pedreno F, Gomez Guevara MC. Health-related quality of life in stroke patients questionnaire, short version (HRQOLISP-40): validation for its use in Colombia. BMC Neurol. 2016;16(1):246. PMID: 27894282 DOI: 10.1186/s12883-016-0770-5
7. Kotlega D, Bialecka M, Kurzawski M, Drozdzik M, Ciecwiez S, Golab-Janowska M, et al. Risk factors of stroke and -717A>G (rs2794521) CRP gene polymorphism among stroke patients in West Pomerania province of Poland. Neurol Neurochir Pol. 2014;48(1):30-4. PMID: 24636767 DOI: 10.1016/j.pjnns.2013.12.001
8. Alkali N, Watt H, Bwala S, Gadzama A. Association of plasma homocysteine and ischemic stroke in Nigerian population. Pak J Med Sci. 2006;22(4):405-8.
9. Shoaeb MA, Shehata MA, Taema KM, Hammouda MA. CRP in cerebrovascular stroke: Prognostic implications. Egyp J Crit Care Med. 2014;2(1):43-52. DOI:10.1016/j.ejccm.2014.03.001
10. de Kleijn MJ, van der Schouw YT, Verbeek AL, Peeters PH, Banga JD, van der Graaf Y. Endogenous estrogen exposure and cardiovascular mortality risk in postmenopausal women. Am J Epidemiol. 2002;155(4):339-45. PMID: 11836198 DOI: 10.1093/aje/155.4.339
11. Price AJ, Wright FL, Green J, Balkwill A, Kan SW, Yang TO, et al. Differences in risk factors for 3 types of stroke: UK prospective study and meta-analyses. Neurology. 2018;90(4):e298-306. PMID: 29321237 DOI: 10.1212/WNL.0000000000004856
12. Ezzati M, Vander Hoorn S, Rodgers A, Lopez AD, Mathers CD, Murray CJ, et al. Estimates of global and regional potentil health gains from reducing muliple major risk factors. Lancet. 2003;362(9380):271-80. PMID: 12892956 DOI: 10.1016/s0140-6736(03)13968-2
13. Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American heart association/American stroke association. Stroke. 2014;45(12):3754-832. PMID: 25355838 DOI: 10.1161/STR.0000000000000046
14. Sacco RL, Adams R, Albers G, Alberts MJ, Benavente O, Furie K, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American heart association/ American stroke association council on stroke: co-sponsored by the council on cardiovascular radiology and intervention: the American academy of neurology affirms the value of this guideline. Circulation. 2006;113(10):e409-49. PMID: 16534023
15. Andreoli TE, Fitz JG, Benjamin I, Griggs RC, Wing EJ. Andreoli and Carpenter's Cecil essentials of medicine E-book: with student consult online access. New York: Elsevier Health Sciences; 2010. P. 416.
16. Mawanda F, Wallace R. Can infections cause Alzheimer's disease? Epidemiol Rev. 2013;35(1):161-80. PMID: 23349428 DOI: 10.1093/epirev/mxs007
17. Elkind MS, Ramakrishnan P, Moon YP, Boden-Albala B, Liu KM, Spitalnik SL, et al. Infectious burden and risk of stroke: the northern Manhattan study. Arch Neurol. 2010;67(1):33-8. PMID: 19901154 DOI: 10.1001/archneurol.2009.271
18. McColl BW, Allan SM, Rothwell NJ. Systemic infection, inflammation and acute ischemic stroke. Neuroscience. 2009;158(3):1049-61. PMID: 18789376 DOI: 10.1016/j.neuroscience.2008.08.019
19. Heuschmann PU, Neureiter D, Gesslein M, Craiovan B, Maass M, Faller G, et al. Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischemic stroke subtypes: results from a population-based case-control study. Stroke. 2001;32(10):2253-8. PMID: 11588309 DOI: 10.1161/hs1001.097096
20. Sawayama Y, Ariyama I, Hamada M, Otaguro S, Machi T, Taira Y, et al. Association between chronic Helicobacter pylori infection and acute ischemic stroke: Fukuoka Harasanshin Atherosclerosis Trial (FHAT). Atherosclerosis. 2005;178(2):303-9. PMID: 15694938 DOI: 10.1016/j.atherosclerosis.2004.08.025
21. Su YP, Niu HW, Chen JB, Fu YH, Xiao GB, Sun QF. Radiation dose in the thyroid and the thyroid cancer risk attributable to CT scans for pediatric patients in one general hospital of China. Int J Environ Res Public Health. 2014;11(3):2793-803. PMID: 24608902 DOI: 10.3390/ijerph110302793
22. Mozaffarian D, Benjamin E, Go A, Arnett D, Blaha M, Cushman M, et al. Heart disease and stroke statistics-2015 update: a report from the American heart association. Circulation. 2015;131(4):e29-322. PMID: 25520374 DOI: 10.1161/CIR.0000000000000152
23. Ameriso SF, Fridman EA, Leiguarda RC, Sevlever GE. Detection of Helicobacter pylori in human carotid atherosclerotic plaque. Stroke Dallas. 2001;32(2):385-9.
24. Mousavi SA, Ataei B, Karimi I, Ashrafi K. Helicobacter pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke. J Res Med Sci. 2011;16(Suppl 1):S407-11. PMID: 22247726
25. Jang SH, Lee H, Kim JS, Park HJ, Jeong SM, Lee SH, et al. Association between helicobacter pylori infection and cerebral small vessel disease. Korean J Fam Med. 2015;36(5):227-32. PMID: 26435813 DOI: 10.4082/kjfm.2015.36.5.227
26. Sagar V, Zafar KS, Kumar G, Veeramachaneni R, Indurkar PS. A study of Helicobacter pylori infection in patients of ischemic cerebro vascular stroke. Int J Res Med Sci. 2016;4:589-92. DOI: 10.18203/2320-6012.ijrms20160321
27. Pietroiusti A, Diomedi M, Silvestrini M, Cupini LM, Luzzi I, Gomez-Miguel MJ, et al. Cytotoxin-associated gene-A--positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation. 2002;106(5):580-4. PMID: 12147540 DOI: 10.1161/01.cir.0000023894.10871.2f
28. Huang WS, Tseng CH, Lin CL, Tsai CH, Kao CH. Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study. QJM. 2014;107(12):969-75. PMID: 24890556 DOI: 10.1093/qjmed/hcu117
29. Russo F, Jirillo E, Clemente C, Messa C, Chiloiro M, Riezzo G, et al. Circulating cytokines and gastrin levels in asymptomatic subjects infected by Helicobacter pylori (H. pylori). Immunopharmacol Immunotoxicol. 2001;23(1):13-24. PMID: 11322645 DOI: 10.1081/iph-100102563
30. Xue FB, Xu YY, Wan Y, Pan BR, Ren J, Fan DM. Association of H. pylori infection with gastric carcinoma: a Meta analysis. World J Gastroenterol. 2001;7(6):801-4. PMID: 11854905 DOI: 10.3748/wjg.v7.i6.801
31. Yu M, Zhang Y, Yang Z, Ding J, Xie C, Lu N. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies. J Stroke Cerebrovasc Dis. 2014;23(9):2233-9. PMID: 25263434 DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.020
32. De Bastiani R, Gabrielli M, Ubaldi E, Benedetto E, Sanna G, Cottone C, et al. High prevalence of Cag‐A positive H. pylori strains in ischemic stroke: a primary care multicenter study. Helicobacter. 2008;13(4):274-7. PMID: 18665936 DOI: 10.1111/j.1523-5378.2008.00610.x

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