Volume 29, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2022)                   Avicenna J Clin Med 2022, 29(2): 88-93 | Back to browse issues page


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1- Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , mk_sabzehei@yahoo.com
3- School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (1245 Views)
Background and Objective: Due to the prevalence of myocardial dysfunction and Patent Ductus Arteriosus (PDA) in a large number of preterm neonates, the prognosis of these infants is highly related to their early diagnosis and treatment. In this regard, the present study aimed to determine the relationship between troponin T level and the prognosis of premature neonates admitted to the Neonatal Intensive Care Unit (NICU) of Fatemieh Hospital in Hamadan.
Materials and Methods: In this cross-sectional study, a certain number of infants who underwent serum levels of troponin T from 72 hours to one week after birth were assessed for demographic information, length of hospital stay, complications during hospitalization, acidosis, inotropic agents, recovery, and mortality, as well as their relationship with troponin level.
Results: Out of 61 neonates, 22 patients had large PDA with a troponin level of 436±50.2 pg/ml, 14 patients had a small PDA with a troponin level of 260.5±89.8 pg/ml, and 25 patients were without PDA with a troponin level of 277.1±229.7 pg /ml (P = 0.203). There was no statistically significant difference between the three groups. The mean levels of troponin were 423±521 and 274±154 pg/ml in deceased and surviving neonates, respectively (P=0.194). Inotropic was significantly higher in deceased patients (P=0.003), and troponin T level was statistically significant (P=0.008). The relationship between troponin level and severe acidosis (P=0.051) was not significant, with a small difference that could be clinically valuable.
Conclusion: Serum troponin T level was higher in preterm neonates with large PDA and deceased ones who received inotropic agents due to hemodynamic disorders and severe acidosis.

Type of Study: Original | Subject: Pediatrics (all specialties)

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