Introduction & Objective : Most of the CRF patients undergo dialysis to correct the CRF complications. Alterations in biochemical parameters of blood depends on the quality of dialysis. Several factors such as membrane , concentration of dialysis solutions , and dilution are involved in this process. Since the efficacy of the dialysis performed in Hamadan have not been studied previously and there was not information about the efficiency of Iranian made membrane (HD , R4 , R3 , S3) , this study was designed and performed.

Materials & Methods: In this study some biochemical parameters including Hb , Hct , alkaline phosphatase , Ca , P , total protein , urea , creatinine before and after dialysis were measured in all patients referring to dialysis center of Hamadan. After collecting the blood samples before and after the dialysis, Hb and Htc were measured using the ABX cell counter. The other parameters were measured using Technicon RA1000 autoanalyser. The mean of these parameters before and after dialysis were compared using paired t-test. The results of different membranes were compared using ANOVA.

Results: Results showed the serum level of total Ca increased 33% after dialysis (P<0.0001) while the P showed 36% decrease (P<0.0001). Alkaline phosphatase activity did not show any significant differences. Comparing the efficacy of different membrane in correction of urea and creatinine , HD membrane showed the most efficiency and R4 had the least (P<0.03). Other parameters did not show significant differences.

Conclusion: The data obtained from this study showed a significant change in Ca , P, and ALP level after dialysis . Also it was concluded that different membrane had different effect on correction of studied parameters.