Volume 6, Issue 1 (Scientific Journal of Hamadan University of Medical Sciences-Autumn & Winter 1999)                   Avicenna J Clin Med 1999, 6(1): 0-0 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Goodarzi M T. Transforming Growth Factor-alpha Induce Synthesis of alpha-1-Antitryspin in Human Hepatoma Cell Line (HepG2). Avicenna J Clin Med 1999; 6 (1)
URL: http://sjh.umsha.ac.ir/article-1-973-en.html
Abstract:   (4245 Views)

Cytokines protein or glycoproteins synthesized by a wide range of cell types including lymphocytes, macrophages, platelets, and monocytes. Cytokines induse synthesis of acute phase protein in hepatocytes. So far eight cytokines has been shown can induce acute phase protein synthesis in hepatocyte and hepatoma cell culture. There are evidences that transforming growth factor-alpha (TGF-a) secrets by tumor cells. In the other hand conditioned medium from ovarian cancer cells can stimulate API synthesis in hepatoma cell line. To show the effect of TGA-a on API synthesis in human hepatoma cell line HepG2, two different concentration of TGF-a were added to culture media of HepG2 cells. API concentration culture media was measured using  rocket immunoassay. The results showed TGF-a in 5 ng/ml increased synthesis of API abut 29%. In higher concentration, TGF-a showed  lower effect. It can be suggested that TGF-a plays role in preventing the effect of proteolytic enzymes by inducing synthesis of anti-proteases.

Type of Study: Original | Subject: Other Clinical Specialties

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb