RT - Journal Article T1 - Protective Effect of Capsicum Frutescens on Contractile Reactivity of Streptozotocin-Diabetic Rats JF - umsha YR - 2005 JO - umsha VO - 12 IS - 2 UR - http://sjh.umsha.ac.ir/article-1-540-en.html SP - 5 EP - 9 K1 - Pepper K1 - Red K1 - Cardiovascular System K1 - Diabetes Mellitus K1 - Contractile Response K1 - Rats AB - Introduction & Objective : Considering the higher incidence of atherosclerosis and cardiovascular disorders in diabetes mellitus, this study was conducted to evaluate the effect of oral one-month administration of red pepper (Capsicum frutescens) on the contractile reactivity of isolated aorta in diabetic rats. Materials & Methods : For this purpose, male Wistar rats(n=32) were randomly divided into control, pepper-treated control, diabetic, and pepper-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). Pepper-treated groups received pepper mixed with standard pelleted food at a weight ratio of 1/15. After one month, contractile reactivity of aortic rings to KCl and noreadrenaline was determined using isolated tissue setup. Results : Serum glucose level showed a significant increase in diabetic group at 2nd and 4th weeks (P LA eng UL http://sjh.umsha.ac.ir/article-1-540-en.html M3 ER -