fa مقایسه سطح سرمی ویتامین D3 در بیماران آلوده به ویروس کووید-19 با افراد غیر مبتلا بيماريهاي عفوني Infectious Diseases پژوهشي Original <span style="font-family:Tahoma;"><strong><span style="position:relative;top:-1.0pt;letter-spacing:.1pt;"><span style="color:#274cc3;"><span style="font-size:10.0pt;">سابقه و هدف:</span></span></span></strong>&nbsp;<span style="color:windowtext;"><span style="font-size:10.0pt;">کروناویروس</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> 2019</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> (</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">COVID-19:</span></span></span><span dir="LTR"><span style="font-size:9.0pt;"> Coronavirus disease 2019</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">) </span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">در اثر نارسایی تنفسی معمولاً باعث مرگ بسیاری از افراد شده و</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> به‌کارگیری روش</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> قرنطینه کردن موجب محروم شدن افراد از ساخت ویتامین </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">D3</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">می‌گردد. در این راستا، مطالعه حاضر با هدف بررسی ارتباط وضعیت ویتامین </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">D3</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">و ریسک ابتلا به </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">COVID-19</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">انجام شد.</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"></span></span><br> <strong><span style="position:relative;top:-1.0pt;letter-spacing:.15pt;"><span style="color:#274cc3;"><span style="font-size:10.0pt;">مواد و روش‌‌ها:</span></span></span></strong>&nbsp;<span style="color:windowtext;"><span style="font-size:10.0pt;">مطالعه مورد- شاهدی حاضر در بیمارستان &quot;بوعلی سینا&quot; قزوین طی شهریور </span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">ماه</span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> سال 1399 انجام شد. گروه مورد، بیماران مبتلا به </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">COVID-19</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">مراجعه‌کننده به این مرکز بودند. گروه شاهد نیز از بین مراجعه‌کنندگان غیر مبتلا به </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">COVID-19</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">انتخاب شدند. در این مطالعه سطح سرمی ویتامین </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">D</span></span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">3</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">شرکت‌کنندگان مورد بررسی قرار گرفت و نتایج ثبت گردید. داده‌های به دست آمده با</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">استفاده</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">از</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">آزمون</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">‌</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">های آماری تحلیل گردیدند.</span></span><span style="font-size:10.0pt;"></span><br> <strong><span style="position:relative;top:-1.0pt;letter-spacing:.1pt;"><span style="color:#274cc3;"><span style="font-size:10.0pt;">یافته‌ها:</span></span></span></strong>&nbsp;<span style="color:windowtext;"><span style="font-size:10.0pt;">گروه</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">مورد که نتیجه آزمایش </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">COVID-19</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> آن</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">‌</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">ها مثبت بود، 81</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">نفر</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">و</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">گروه شاهد،</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">77</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">نفر</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">بودند</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">.</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> 67</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">نفر</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">از</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">شرکت‌کنندگان</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">در</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">مطالعه</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">مرد</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">و</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">91</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">نفر</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">زن</span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">بودند</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">.</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> میانگین سنی شرکت‌کنندگان 40/14</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">&plusmn;</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">80/44 سال بود. از کل بیماران مبتلا به </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">COVID-19</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">، 66 نفر (5/81 درصد) دچار کمبود ویتامین </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">D3</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;"> بودند؛ در حالی که در گروه شاهد، 44 نفر (1/57 درصد) کمبود ویتامین </span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">D3</span></span></span> <span style="color:windowtext;"><span style="font-size:10.0pt;">داشتند (001/0</span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:9.0pt;">P</span></span></span><span dir="LTR"><span style="color:windowtext;"><span style="font-size:10.0pt;">=</span></span></span><span style="color:windowtext;"><span style="font-size:10.0pt;">).</span></span><span style="font-size:10.0pt;"></span><br> <strong><span dir="RTL" style="position:relative;top:-1.0pt;letter-spacing:-.1pt;"><span style="color:#274cc3;"><span style="font-size:10.0pt;">نتیجه‌گیری:</span></span></span></strong>&nbsp;<span dir="RTL" style="letter-spacing:-.1pt;"><span style="font-size:10.0pt;">نتایج نشان دادند که ویتامین </span></span><span style="letter-spacing:-.1pt;"><span style="font-size:9.0pt;">D3</span></span> <span dir="RTL" style="letter-spacing:-.1pt;"><span style="font-size:10.0pt;">یک عامل حفاظتی قابل قبول در مقابل بیماری </span></span><span style="letter-spacing:-.1pt;"><span style="font-size:9.0pt;">COVID-19</span></span><span dir="RTL" style="letter-spacing:-.1pt;"><span style="font-size:10.0pt;"> است</span></span><span dir="RTL"><span style="font-size:10.0pt;"> و کمبود آن موجب افزایش احتمال ابتلا به این بیماری خواهد شد.</span></span></span> <strong>Background and Objective:</strong> Coronavirus Disease 2019 (COVID-19) has caused the death of many people, mainly by causing respiratory failure. The method of quarantine for the control of this disease leads to deprivation of vitamin D3 production. In this regard, this study aimed to investigate the relationship between serum vitamin D3 level and risk of COVID-19.<br> <strong>Materials and Methods:</strong> This case-control study was conducted in BouAli Sina Hospital in Qazvin, Iran in September 2020. The statistical population of the case group included patients with COVID-19 referred to this center, while the control group comprised non-COVID-19 patients who referred to the center. Vitamin D3 levels of the participants were assessed and the findings were recorded. The collected data were analyzed using statistical tests.<br> <strong>Results:</strong> The case group with positive COVID-19 included 81 patients and the control group consisted of 77 patients. The mean age of the subjects was 44.80&plusmn;14.40 years, and 67 of them were male. Based on the findings, 66 (81.5%) out of all the patients with COVID-19 were deficient in vitamin D3, while in the control group, 44 (57.1%) subjects were deficient in vitamin D3 (P=0.001). &nbsp;<br> <strong>Conclusion:</strong> In this study, it was found that vitamin D3 is an acceptable protective factor against COVID-19 and its deficiency will increase the risk of developing this disease.<br> &nbsp; عوامل خطر, کروناویروس, کمبود ویتامین D3 COVID-19, Risk Factors, Vitamin D3 Deficiency 13 19 http://sjh.umsha.ac.ir/browse.php?a_code=A-11-1821-2&slc_lang=fa&sid=1 Alireza Nikoonejad علیرضا نیکونژاد 100319475328460014820 100319475328460014820 No Assistant Professor, Department of Infectious Diseases, Clinical Research Development Unit, BouAli Sina Hospital, Qazvin University of Medical of Sciences, Qazvin, Iran Ali Shafizadeh Arjomandi علی شفیع‌زاده ارجمندی 100319475328460014821 100319475328460014821 No General Practitioner, Clinical Research Development Unit, BouAli Sina Hospital, Qazvin University of Medical of Sciences, Qazvin, Iran Samira Dodangeh سمیرا دودانگه 100319475328460014822 100319475328460014822 No PhD, Department of Medical Parasitology and Mycology, Medical Microbiology Research Center, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Abbas Allami عباس علامی allami9@yahoo.com 100319475328460014823 100319475328460014823 Yes Professor, Department of Infectious Diseases, Clinical Research Development Unit, BouAli Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran