fa مقایسه‌ی اثر ترکیب اریترومایسین و زینک استات موضعی با اریترومایسین موضعی در درمان آکنه‌ی خفیف تا متوسط درماتولوژي Dermatology پژوهشي Original <span style="font-family:Tahoma;"><span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:-.2pt">سابقه و هدف:</span></span></span></span></span></span></b>&nbsp;<span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">با توجه به نقش باکتری ها در ایجاد برخی از اشکال آکنه، در سال‌های اخیر استفاده از آنتی بیوتیک ها به‌همراه سایر داروها به‌منظور درمان آن، نتایج مثبتی داشته است.</span></span></span> <span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">این مطالعه با هدف مقایسه‌ی اثر ترکیب اریترومایسین و زینک استات موضعی با اریترومایسین موضعی در درمان آکنه ولگاریس خفیف تا متوسط انجام شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">مواد و روش‌‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">:</span></span></span></span></span></b><b>&nbsp;</b><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">در این مطالعه‌ی کارآزمایی بالینی، 76 بیمار مبتلا به آکنه که به کلینیک تخصصی پوست بیمارستان فرشچیان (سینا) همدان مراجعه کرده بودند، به‌طور تصادفی به دو گروه ‌درمانی </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> (39 نفر) و </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> (37 نفر) تقسیم شدند. گروه </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> تحت درمان با محلول موضعی اریترومایسین 4درصد به‌تنهایی و گروه </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> تحت درمان با محلول ترکیبی موضعی اریترومایسین 4درصد و زینک استات 2/1درصد به‌صورت دو بار در روز، به‌مدت سه ماه قرار گرفتند.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">یافته‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">:</span></span></span></span></span></b>&nbsp;<span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">در گروه‌های </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> و </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> به‌ترتیب میانگین نمره‌ی شدت ضایعات قبل از درمان 6/5</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">21/1 و 5/4</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">21/9 (0/555</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">)، بعد از ماه اول درمان 6/4</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">17/0 و 5/9</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">15/7 (0/578</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">)، بعد از ماه دوم درمان 4/5</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">9/1 و 3/3</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">6/4 (0/014</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">) و بعد از ماه سوم درمان 3/0</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">4/0 و 3/0</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.2pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">2/0 (0/001</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">) و فراوانی بهبود کامل به‌ترتیب 38/5 و 64/9درصد بود (0/021</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">). در گروه </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">، شدت پاپول در ماه دوم (0/002</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">) و سوم (0/001</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">P=</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">) درمان به‌طور معنی</span></span></span>&nbsp;<span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">داری کمتر از گروه </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt"> بود.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">نتیجه‌گیری:</span></span></span></span></span></span></b><b>&nbsp;</b><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.2pt">ترکیب اریترومایسین 4درصد با زینک استات 1/2درصد و استفاده از آن به‌صورت محلول موضعی، اثربخشی بیشتری نسبت به محلول موضعی اریترومایسین 4درصد به‌تنهایی در درمان ضایعات آکنه دارد.</span></span></span></span></span></span></span></span><br> &nbsp;</span> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Background and Objective:</span></span></span></span></b> <span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:">Considering the role of bacteria in causing some forms of acne, in recent years, the use of antibiotics along with other medications has had positive results in acne treatment; therefore, the present study aimed to compare the effect of the combination of topical erythromycin and zinc acetate with topical erythromycin alone in treating mild to moderate acne vulgaris.</span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3">Materials and Methods:</span></span></span></b> <span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:">In this clinical trial, 76 patients with acne vulgaris who were referred to a specialized skin clinic were selected and randomly assigned into two treatment groups, namely, A (n=39) and B (n=37). Group A was treated with a local solution of erythromycin 4% without zinc acetate, and group B was treated with a combined local solution of erythromycin 4% and zinc acetate 1.2%. The treatment continued twice a day for three months.</span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Results:</span></span></span></span></b> <span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt">In groups, A and B, respectively, the average lesion intensity score before treatment was 21.1 &plusmn; 6.5 and 21.9 &plusmn; 5.4 (P=0.555), the first month of treatment was 17.0 &plusmn; 6.4 and 15.7 &plusmn; 5.9 (P=0.578), the second month of treatment 9.1 &plusmn; 4.5 and 6.4 &plusmn; 3.3 (P=0.014), the third month of treatment 4.0 &plusmn; 3.0 and 2.0 &plusmn; 3.0 (P=0.001), and the frequency of complete recovery was 38.5 and 64.9%, respectively (P=0.021). In group B, the severity of papules in the second (P=0.002) and third (P=0.001) months of the treatment was significantly lower than in group A.</span></span></span></span></span></span></span><br> <b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:.1pt">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:black">Based on the obtained results, using a combination of erythromycin 4% with zinc acetate 1.2% as a topical solution is more effective than the topical solution of erythromycin 4% alone in treating acne lesions</span></span></span> آکنه ولگاریس, اریترومایسین, زینک استات Acne Vulgaris, Erythromycin, Zinc Acetate 65 71 http://sjh.umsha.ac.ir/browse.php?a_code=A-12-179-9&slc_lang=fa&sid=1 Zahra Moradhaseli زهرا مراد حاصلی 100319475328460018921 0009-0008-2785-2656 No Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran گروه پوست، دانشکده‌ی پزشکی، مرکز تحقیقات بیمارستان سینا، دانشگاه علوم پزشکی همدان، همدان، ایران Elaheh Talebi Ghane الهه طالبی قانع 100319475328460018922 100319475328460018922 No Modeling of Noncommunicable Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran مرکز تحقیقات مدل‌سازی بیماری‌های غیرواگیر، دانشگاه علوم پزشکی همدان، همدان، ایران Mohammadreza Sobhan محمدرضا سبحان mreza_sobhan@yahoo.com 100319475328460018923 100319475328460018923 Yes Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran گروه پوست، دانشکده‌ی پزشکی، مرکز تحقیقات بیمارستان سینا، دانشگاه علوم پزشکی همدان، همدان، ایران