fa بررسی پاسخ به درمان دارویی در کودکان مبتلا به سنگ مجرای ادراری اطفال (همه تخصص‌ها) Pediatrics (all specialties) پژوهشي Original <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.1pt">سابقه و هدف:</span></span></span></span></span></span></b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">&nbsp;تشخیص و درمان سنگ&rlm;های سیستم ادراری به&rlm;خصوص با توجه به</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">نبود علائم اختصاصی، خطرات و عوارض احتمالی آن، در کودکان از اهمیت زیادی برخوردار است.</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> به همین منظور </span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">این مطالعه با هدفِ تعیین میزان پاسخ به درمان دارویی در کودکان مبتلا به سنگ مجرای ادرار انجام گرفت. </span></span><b><span lang="AR-SA" style="font-size:10.0pt"><span style="font-family:"B Nazanin""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">مواد و روش‌‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">: </span></span></span></span></span></b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">در این مطالعۀ توصیفی </span></span><span lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">&ndash;</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> مقطعی، ۲۹۸ کودک ارجاع&rlm;شده به درمانگاه کلیۀ کودکان با تشخیص سـنگ مجـرای ادراری بررسی شدند. اطلاعات دموگرافیک و بالینی بیماران از پروندۀ آنان استخراج شد و در چک&rlm;لیست&rlm;های طراحی&rlm;شده برای هر بیمـار ثبـت شد و</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> با استفاده از آزمون&rlm;های مجذور کای و تی</span></span><span lang="HE" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">&rlm;</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">تست</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> مقایسه شد. داده‌ها با نرم‌افزار </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPSS</span></span><b> </b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">24</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">در سطح معنی&rlm; داری </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">(0.05=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">)</span></span><i> </i><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">تجزیه و تحلیل شدند.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">یافته‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">: </span></span></span></span></span></b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">از 298 کودک مبتلا به سنگ مجرای ادراری زیر 3 سال، 48.3 % پسر و 51.7 % دختر بود.</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">از حیث بروز علائم بالینی، 35</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">% از بیماران فاقد علامت و</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">هماچوری (18.5</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">%) فراوان&rlm;ترین آن&rlm;ها بود. مهم&rlm;ترین عامل خطر، سابقۀ خانوادگی (64.8</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">%) گزارش شد. هایپراوریکوزوری شایع&rlm;ترین اختلال متابولیک و هیدرونفروز مهم&rlm;ترین مشکل همراه بیماران بود. نتایج تحلیل&rlm;های آماری نشان داد که بین اندازۀ سنگ با علائم بیماری، تعداد سنگ، اختلالات متابولیک، مشکلات همراه، داروی مصرفی، نوع عمل جراحی، تعداد عمل جراحی، تعداد دفعات عود سنگ، و نتایج درمان دارویی ارتباط آماری معناداری وجود دارد. </span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:-.15pt">نتیجه‌گیری: </span></span></span></span></span></span></b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">غالب کودکان دارای سنگ&rlm;های کوچک&rlm;تر از ۵ میلی&rlm;متر، پاسخ مناسب به درمان دارویی دادند و عود سنگ در این بیماران کمتر بود. در مطالعۀ حاضر بیماران با سنگ&rlm;های بزرگ&rlm;تر از ۵ میلی&rlm;متر، پاسخ به درمان دارویی کمتری و متعاقب آن نیاز به جراحی بیشتر، به&rlm;ویژه جراحی&rlm;های تهاجمی &rlm;تر پیدا کردند</span></span></span></span></span></span></span> <span style="font-size:14px;"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Background and Objective:</span></span></span></b> <span style="font-family:Optima">The diagnosis and treatment of urinary system stones are highly crucial, especially in children due to the lack of specific symptoms, risks, and possible complications. Therefore, this study was conducted to investigate the response rate to drug treatment in children with ureteral stones.</span></span></span></span><br> <span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3">Materials and Methods:</span></span></b> <span style="font-family:Optima">In this descriptive-cross-sectional study, 298 children with urolithiasis who were referred to the Children&#39;s Kidney Clinic (Hamadan University of Medical Sciences) were reviewed. Demographic and clinical information of the patients was extracted from their records and recorded in checklists designed for each patient, then compared using chi-square and t-test analytical statistics. Data were analyzed using SPSS software (version 24) at the significance level. (P<0.05)</span></span></span></span><br> <span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Results:</span></span></span></b> <span style="font-family:Optima">Of the 298 children under the age of 3 years with urinary tract stones, 48.3% were boys and 51.7% were girls. Regarding the prevalence of clinical symptoms, 35% of the patients were asymptomatic, and hematuria (18.5%) was the most common symptom. The most significant risk factor reported was a family history (64.8%). Hyperuricosuria was the most common metabolic disorder, and hydronephrosis was the most significant associated problem among the patients. The results of statistical analyses showed a statistically significant relationship between stone size and symptoms of the disease, number of stones, metabolic disorders, concomitant problems, medication used, type of surgery, number of surgeries, number of stone recurrences, and drug treatment results.</span></span></span></span><br> <b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:-.1pt">Conclusion:</span></span></span></b> <span style="font-family:Optima"><span style="color:black">The majority of children with stones smaller than 5 mm responded well to drug treatment, and the recurrence of stones was less in these patients. In the present study, patients with stones larger than 5 mm responded less to drug treatment and subsequently required more surgery, especially more invasive surgeries.</span></span></span> اختلالات متابولیک, جراحی, دارودرمانی, سنگ‌های ادراری Drug Therapy, Metabolic Disorders, Surgery, Urinary Calculi 218 225 http://sjh.umsha.ac.ir/browse.php?a_code=A-12-2600-1&slc_lang=fa&sid=1 Hossein Emad Momtaz حسین‌عماد ممتاز momtaz@umsha.ac.ir 100319475328460024462 100319475328460024462 Yes Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran گروه اطفال، دانشکدۀ پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Hamed Kazemi Najafabadi حامد کاظمی نجف‌آبادی hamedkazemi@gmail.com 100319475328460024463 100319475328460024463 No Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran گروه اطفال، دانشکدۀ پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Azar Pirdehghan آذر پیردهقان azar_pirdehghan@yahoo.com 100319475328460024464 100319475328460024464 No School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran گروه پزشکی اجتماعی، دانشکدۀ پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران