fa بررسی اثر داکسی‌سایکلین بر پیامدهای بالینی بیماران مبتلا به استروک ایسکمیک نورولوژي Neurology پژوهشي Original <span style="font-family:Tahoma;"><span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.1pt">سابقه و هدف:</span></span></span></span></span></span></b>&nbsp;<span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">سکته‌ی مغزی دومین عامل اصلی ناتوانی و مرگ‌ومیر در سراسر جهان است. این مطالعه با هدف تعیین اثر داکسی‌سایکلین بر پیامدهای بالینی بیماران مبتلا به استروک ایسکمیک انجام شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">مواد و روش‌‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">:</span></span></span></span></span></b><b>&nbsp;</b><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">در این مطالعه‌ی کارآزمایی بالینی دوسویه کور، تعداد 60 بیمار مبتلا به استروک ایسکمیک در 24 ساعت اول پس از وقوع سکته‌ی مغزی انتخاب و به‌صورت تصادفی در دو گروه مداخله و کنترل قرار داده شدند. در گروه مداخله بیماران در کنار درمان‌های استاندارد، به مدت 7 روز و هر 12 ساعت 100 میلی‌گرم داکسی‌سایکلین دریافت کردند. هر دو گروه قبل از شروع مداخله، روز هفتم، روز سی‌ام و روز نودم بعد از درمان از نظر شدت پیامدهای بالینی ناشی از سکته‌ی مغزی با تست‌های (</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">mRS</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">Modified Rankin Scale</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> و (</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">NIHSS</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">National Institutes of Health Stroke Scale</span></span></span><span style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> پیگیری شدند.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">یافته‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">:</span></span></span></span></span></b>&nbsp;<span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">میانگین سن بیماران در گروه مداخله و کنترل به‌ترتیب برابر با 12/15</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.1pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">68/33 و 9/99</span></span></span><span lang="FA" style="font-size:10.0pt"><span cambria=""><span style="letter-spacing:-.1pt">&plusmn;</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">67/40 سال بود (0/05<</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">P</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">). بین گروه مداخله و کنترل از نظر نمره‌ی </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">NIHSS</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> و </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">mRS</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> پایه و روز هفتم تفاوت معنادار مشاهده نشد، اما در گروه مداخله نمره‌ی </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">NIHSS</span></span></span><span style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> در روز سی‌ام (0/007=</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">P</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) و روز نودم (0/001></span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">P</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) و نمره‌ی </span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">mRS</span></span></span><span style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt"> در روز سی‌ام (0/009=</span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">P</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) و روز نودم (0/01></span></span></span><span dir="LTR" style="font-size:8.0pt"><span new="" roman="" times=""><span style="letter-spacing:-.1pt">P</span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="letter-spacing:-.1pt">) به‌طور معناداری کمتر از گروه کنترل بود.</span></span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">نتیجه‌گیری:</span></span></span></span></span></span>&nbsp;</b><span dir="RTL" lang="FA" style="font-size:10.0pt"><span b="" nazanin=""><span style="color:black"><span style="letter-spacing:-.1pt">در بیماران مبتلا به استروک ایسکمیک، تجویز داکسی‌سایکلین به مدت 7 روز و هر 12 ساعت 100 میلی‌گرم بدون ایجاد عوارض درخور توجه باعث کاهش اختلالات نورولوژیک و بهبود پیامد بالینی بیماران طی یک تا سه ماه بعد از درمان می‌شود.</span></span></span></span></span> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:-.1pt">Background and Objective:</span></span></span></span></b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt"> Stroke is the second leading cause of disability and mortality across the globe. The present study aimed to assess the effect of doxycycline on clinical outcomes of patients with ischemic stroke.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3">Materials and Methods:</span></span></span></b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt"> In this double-blind clinical trial, 60 patients with ischemic stroke were selected in the first 24 hours of post-stroke and randomly assigned to two groups: intervention and control. In the intervention group, patients received 100 mg of doxycycline every 12 hours for seven days in addition to standard treatments. Both groups were followed up before the intervention, on days 7, 30, and 90 after the treatment in terms of the severity of stroke clinical outcomes using National Institutes of Health Stroke Scale&nbsp;(NIHSS) and Modified Rankin Scale (mRS) tests.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Results:</span></span></span></span></b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt"> The mean age of patients in the intervention and control groups were 68.33&plusmn;12.15 and 67.40&plusmn;9.99 years (P>0.05). No significant difference was observed between the intervention and control groups in terms of&nbsp;NIHSS and mRS scores at baseline and on the seventh day. Nonetheless, in the intervention group, the NIHSS score on days 30 (P=0.007) and 90 (P<0.001), as well as the mRS</span></span></span> <span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt">score on days 30 (P=0.009) and 90 (P<0.01) was significantly less than the control group.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="color:#274cc3"><span style="letter-spacing:.1pt">Conclusion:</span></span></span></span></b><span style="font-size:9.0pt"><span lt="" optima="" std="" style="font-family:"><span style="letter-spacing:-.1pt"> In ischemic stroke, the administration of doxycycline 100 mg every 12 hours for seven days is safe, reduces neurological disorders, and improves the clinical outcome of patients within one to three months after the treatment.</span></span></span></span></span></span></span><br> &nbsp; پیامد بالینی, داکسی‌سایکلین, سکته‌ی مغزی ایسکمیک Clinical outcome, Doxycycline, Ischemic stroke 83 90 http://sjh.umsha.ac.ir/browse.php?a_code=A-12-386-2&slc_lang=fa&sid=1 Mojtaba Khazaei مجتبی خزایی 100319475328460023525 100319475328460023525 No Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran گروه نورولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران Zahra Aminian زهرا امینیان 100319475328460023526 100319475328460023526 No Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran کمیته‌ی تحقیقات دانشجویی، دانشگاه علوم پزشکی همدان، همدان، ایران Maryam Mehrpooya مریم مهرپویا 100319475328460023527 100319475328460023527 No Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran مرکز تحقیقات گیاهان دارویی و فراورده‌های طبیعی، دانشگاه علوم پزشکی همدان، همدان، ایران Salman Khazaei سلمان خزایی salman.khazaei61@gmail.com 100319475328460023528 100319475328460023528 Yes Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran مرکز تحقیقات علوم بهداشتی، دانشگاه علوم پزشکی همدان، همدان، ایران