fa بررسی تغییرات هموگلوبین، هماتوکریت، اسمولاریته و الکترولیت‌های سرم در اعمال جراحی رزکشن پروستات از راه مجاری ادراری ارولوژي Urology پژوهشي Original <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.1pt">سابقه و هدف:</span></span></span></span></span></span></b>&nbsp;<span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">هایپرپلازی خوش‌خیم پروستات (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Benign</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Prostatic</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Hyperplasia</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">BPH</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">) از بیماری‌های مجاری ادراری تحتانی در مردان است. رزکشن پروستات از راه مجاری ادراری (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Transurethral</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Resection</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">of</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Prostate</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">TURP</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">) یکی از راه&rlm;های درمان این بیماری است. جذب مایع شست&rlm;وشو در حین جراحی می‌تواند منجر به بروز اختلالات هماتولوژیک و الکترولیتی، ازجمله سندرم </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">TURP</span></span><b> </b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">شود. هدف از مطالعۀ حاضر بررسی دقیق‌ این پارامترها بوده است.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">مواد و روش‌‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.15pt">:</span></span></span></span></span></b><b>&nbsp;</b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">این مطالعه از نوع توصیفی</span></span><span lang="AR-SA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">&ndash;</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">مقطعی و گذشته‌نگر بود و داده‌ها از طریق استخراج سیستماتیک اطلاعات ثبت‌شده در سوابق پزشکی بیماران جمع‌آوری شد. داده‌های اولیه ابتدا در نرم‌افزار اکسل جمع&rlm;آوری شدند و سپس از نرم&rlm;افزار آماری </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPSS</span></span> <span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">نسخۀ 25 به&rlm;منظور تجزیه&rlm;وتحلیل داده&rlm;ها استفاده شد. از آزمون‌های تی‌زوجی، مربع کای، دقیق فیشر، و من ویتنی برای تجزیه&rlm;وتحلیل داده‌ها استفاده شد</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">. سطح معنی‌داری در مطالعه 05/0 در نظر گرفته شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span ms="" style="font-family:" trebuchet=""><span style="color:black"><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">یافته‌ها</span></span></span></span></span></span></b><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:.2pt">: </span></span></span></span></span></b><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">پ</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">س از عمل، میانگین هموگلوبین از </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">13.80</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> به </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">12.87</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> گرم بر دسی‌لیتر (0.05></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">) و هماتوکریت از </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">42.43 درصد </span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">به </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">39.09 درصد </span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">(0.05></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">) کاهش یافت که این تغییرات معنادار بود. همچنین تغییرات معنی‌داری در الکترولیت‌های سرم مشاهده شد، به‌طوری‌که سطح سدیم از </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">139.98</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> به </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">139.96&nbsp;</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">میلی‌اکی‌والان بر لیتر کاهش یافت (0.003</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">) و سطح پتاسیم نیز از </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">4.37</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> به </span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">4.11</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"> میلی‌اکی‌والان بر لیتر رسید</span></span><b> </b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">(0.05></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><b><span lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:">).</span></span></b><span lang="AR-SA" style="font-size:10.0pt"><span style="background:white"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#274cc3"><span style="position:relative"><span style="top:-1.0pt"><span style="letter-spacing:-.15pt">نتیجه‌گیری: </span></span></span></span></span></span></b><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این نتایج نشان&rlm;دهندۀ تأثیر قابل توجه جراحی</span></span></span><b> </b><span style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">TURP</span></span></span><b> </b><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بر پارامترهای هماتولوژیک و الکترولیتی بیماران هستند و بر پایش دقیق این فاکتورها پس از عمل تأکید دارند.</span></span></span> <span style="font-size:14px;"><span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Background and Objective:</span></span></span></b> <span style="font-family:Optima">Benign prostatic hyperplasia (BPH) is one of the most common lower urinary tract disorders in men. Transurethral resection of the prostate (TURP) is a standard treatment modality for this condition. Absorption of irrigation fluid during surgery may lead to hematological and electrolyte disturbances, including TURP syndrome. The present study aimed to precisely investigate changes in these parameters.</span></span></span></span><br> <span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3">Materials and Methods:</span></span></b> <span style="font-family:Optima">This descriptive cross-sectional retrospective study collected data through systematic extraction of information recorded in patients&#39; medical records. Initial data were compiled in Excel software, followed by statistical analysis using SPSS version 25. Paired t-test, chi-square, Fisher&#39;s exact test, and Mann-Whitney U test were employed for data analysis, with a significance level set at 0.05.</span></span></span></span><br> <span style="unicode-bidi:embed"><span ms="" trebuchet=""><span style="color:black"><b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:.15pt">Results:</span></span></span></b> <span style="font-family:Optima">Postoperatively, mean hemoglobin decreased from 13.80 to 12.87 g/dL (P</span> <span dir="RTL" lang="AR-SA"><span b="" nazanin="">></span></span><span style="font-family:Optima">0.05) and hematocrit from 42.43% to 39.09% (P </span><span dir="RTL" lang="AR-SA"><span b="" nazanin="">></span></span><span style="font-family:Optima"> 0.05), with these changes being statistically significant. Significant alterations were also observed in serum electrolytes; sodium levels decreased from 139.98 to 139.96 mEq/L (P = 0.003), and potassium levels from 4.37 to 4.11 mEq/L (P</span><span dir="RTL" lang="AR-SA"><span b="" nazanin="">></span></span><span style="font-family:Optima"> 0.05). Changes in serum osmolality were not statistically significant.</span></span></span></span><br> <b><span style="font-family:Optima"><span style="color:#274cc3"><span style="letter-spacing:-.1pt">Conclusion:</span></span></span></b> <span style="font-family:Optima"><span style="color:black">These findings highlight the substantial impact of TURP on patients&#39; hematological and electrolyte parameters and underscore the necessity for meticulous postoperative monitoring of these factors.</span></span></span> الکترولیت‌های سرم, تغییرات هماتولوژیک, رزکشن پروستات از راه مجاری ادراری, هایپرپلازی پروستات, هموگلوبین Hematological Changes, Hemoglobin, Prostatic Hyperplasia, Serum Electrolytes, Transurethral Resection of Prostate 226 232 http://sjh.umsha.ac.ir/browse.php?a_code=A-12-2353-3&slc_lang=fa&sid=1 Amirhossein Bigdeli امیرحسین بیگدلی karampor1@yahoo.com 100319475328460024392 0009-0002-1065-7236 No Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran کمیتۀ تحقیقات دانشجویی، دانشگاه علوم پزشکی همدان، همدان، ایران Arezou Karampourian آرزو کرمپوریان a.karampourian@umsha.ac.ir 100319475328460024393 100319475328460024393 Yes Department of Health in Emergency and Disaster, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran گروه سلامت در حوادث و بلایا، دانشکدۀ بهداشت، دانشگاه علوم پزشکی همدان، همدان، ایران Ali Safdari علی صفدری asafdari.nu@gmail.com 100319475328460024394 100319475328460024394 No Department of Nursing, School of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran گروه پرستاری، دانشکدۀ پرستاری و مامایی، دانشگاه علوم پزشکی سمنان، سمنان، ایران Amirmahmoud Moshki امیرمحمود مشکی AmirMahmoud.Meshki@gmail.com 100319475328460024395 0009-0004-0265-9017 No Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran کمیتۀ تحقیقات دانشجویی، دانشگاه علوم پزشکی همدان، همدان، ایران