Volume 20, Issue 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2014)                   Avicenna J Clin Med 2014, 20(4): 342-345 | Back to browse issues page

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Eshghi G, Babaie H, Faghani H. A Case Report of Keratoderma and Bilateral Deafness. Avicenna J Clin Med 2014; 20 (4) :342-345
URL: http://sjh.umsha.ac.ir/article-1-121-en.html
1- , gholamrezaeshghi58@gmail.com
Abstract:   (8397 Views)

Introduction: Various inherited or acquired disorders are characterized by palmoplantar kera-toderma hyperkeratosis of hands and feet, and when accompanied with deafness indicates mutations in the gene encoding connexin -26 or a particular mutation (A7445G) of the mito-chondrial t-RNA coded for serine (MT-TS1) is created.

Case Report: On skin examination of a 7 year old boy, we observed hyperkeratosis of palm and sole, elbows and knees (Keratoderma of palms &soles with extensor surface of limbs involvement), and found out the history and evidence of sensory-neural deafness since birth-day and he had undergone cochlear implant at the age of two. Thus this patient is placed in a rare group of keratoderma associated with sensory-neural deafness. Since there is no his-tory of similar disease in his pedigree, we suspected the boy had a rare type of keratoderma associated with sensory- neural deafness that has mitochondrial inheritance. In reported cases of this disorder in the world there is no involvement of limb's extensor. So we probably report a new subtype of the rare disorder or a rare separate disorder.

Conclusion: The patient is a case with diffuse palmoplantar keratoderma with the involvement of extensor surfaces and sensory-neural deafness that have mitochondrial inheritance that is unlikely to be reported yet. The disease should be controlled with maintenance treatments.

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Type of Study: Case Report | Subject: Other Clinical Specialties

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