Volume 32, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2025)
Avicenna J Clin Med 2025, 32(1): 21-27 |
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Kazempour M, Ranjbar Arani A, Farsad F, Negaresh O. Study of Cognitive Impairment and Depression in Patients with Systemic Lupus Erythematosus Compared to Patients with Type 2 Diabetes. Avicenna J Clin Med 2025; 32 (1) :21-27
URL: http://sjh.umsha.ac.ir/article-1-3198-en.html
URL: http://sjh.umsha.ac.ir/article-1-3198-en.html
1- Department of Rheumatology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Internal Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,drranjbar.ar@gmail.com
3- Department of Internal Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Internal Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
3- Department of Internal Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (89 Views)
Background and Objective: Systemic lupus erythematosus (SLE) and type 2 diabetes (T2D) are both chronic diseases that impact various organs and systems in the body across the globe. These conditions often necessitate long-term medication and may lead to psychiatric disorders, which can complicate the management of chronic diseases. Despite the known effects of these two diseases on cognitive function, there is limited comparative data on these conditions. The present study aimed to assess the prevalence of cognitive impairment and depression in these patients.
Materials and Methods: In this case-control study, 77 patients with lupus erythematosus, 110 patients with type 2 diabetes, and 52 healthy individuals were included and examined for cognitive impairment and depression.
Results: Cognitive impairment occurred with a frequency of 20% in people with diabetes, 15.6% in people with lupus, and 9.6% in healthy people. Although patients with diabetes had a worse cognitive status without considering the factors of age, gender, and education level (P=0.039), after adjusting for these factors, people with lupus had lower cognitive scores than normal people and patients with diabetes (P=0.12). Depression was reported in 14.55% of patients with diabetes, 51.9% of patients with lupus, and 3.8% of healthy people. The highest level of depression was observed in lupus, diabetes, and normal people, respectively (P<0.05).
Conclusion: Lupus and diabetes are both chronic diseases that cause depression and cognitive disorders. The results highlighted the necessity of screening these disorders for chronic diseases.
Materials and Methods: In this case-control study, 77 patients with lupus erythematosus, 110 patients with type 2 diabetes, and 52 healthy individuals were included and examined for cognitive impairment and depression.
Results: Cognitive impairment occurred with a frequency of 20% in people with diabetes, 15.6% in people with lupus, and 9.6% in healthy people. Although patients with diabetes had a worse cognitive status without considering the factors of age, gender, and education level (P=0.039), after adjusting for these factors, people with lupus had lower cognitive scores than normal people and patients with diabetes (P=0.12). Depression was reported in 14.55% of patients with diabetes, 51.9% of patients with lupus, and 3.8% of healthy people. The highest level of depression was observed in lupus, diabetes, and normal people, respectively (P<0.05).
Conclusion: Lupus and diabetes are both chronic diseases that cause depression and cognitive disorders. The results highlighted the necessity of screening these disorders for chronic diseases.
Type of Study: Original |
Subject:
Internal Medicine
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