Volume 12, Issue 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2006)                   Avicenna J Clin Med 2006, 12(4): 11-16 | Back to browse issues page

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Mazdeh M, Monsef A R, Mani Kashani K. Study of Relationship between Homocysteine and Stroke. Avicenna J Clin Med 2006; 12 (4) :11-16
URL: http://sjh.umsha.ac.ir/article-1-511-en.html
1- , mazdeh_m2007@yahoo.com
Abstract:   (4887 Views)

Introduction & Objective : Stroke is the third most common cause of death in the world , and it is also a major cause of longterm disability . The most promising strategy to reduce the stroke is prevention and the success of this prevention strategy depends , however , on identifying and controlling all important causal and modifiable risk factors. A previously emerging risk factor for stroke , which is prevalent and modifiable and may be causal , is elevated plasma homocysteine. The author of this study hypothesized that elevated homocysteine (Hcys) is a risk factor for all of stroke subtypes in which atherosclerosis plays a primary role.

Materials & Methods : This case-controlled study included 58 patients (33 men and 25 women ) with stroke who were admitted to a university teaching hospital in Hamadan. The control group consisted of 103 randomly selected subjects (60 men and 53 women) with a mean age of 50 years who did not have a stroke. Both groups of patients provided a history of their vascular modifiable risk factors , effectiveness factor in plasma Hcys level . Then analyzed fasting blood samples , for plasma Hcys levels.

Results : Compared with control subjects , ischemic (n=44) , and hemorrhagic (n=14) strokes had higher geometric mean values of total Hcys and higher proportions of Hcys³ 11.0 mmol/L that was significant.

Conclusion: There is a significant association between elevated Hcys and all of stroke subtypes.

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Type of Study: Original | Subject: Other Clinical Specialties

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