Introduction : Epithelial cell carcinoma is the most common malignant neoplasm of gallbladder , but squamous cell carcinoma (SCC) is rare.
Case Report: Following the diagnosis of hydropsy of gallbladder in a sonography of a 60 years-old woman, cholesistectomy was performed. On macroscopic pathological examination, brownish deformed gallbladder was seen. After opening, on mucosal surface there was a cream, elastic polypoid tumoral lesion (2×1×0.5 cm). On microscopic evaluation, a pattern of pure and differentiated invasive Squamous Cell Carcinoma was diagnosed.
Conclusion: During the last twenty-two years, this has been the first report of SCC of gallbladder from province of Hamadan with incidence of 2.8% in Iran. This case can be used in hystogenesis of SCC of gallbladder.
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