Volume 9, Issue 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2003)                   Avicenna J Clin Med 2003, 9(4): 0-0 | Back to browse issues page

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Bakht R, Modarres Gilani M. A Comparative Study of Trichomonas Vaginitis Treatment with Single and Seven Day Metronidazole Regimen . Avicenna J Clin Med 2003; 9 (4)
URL: http://sjh.umsha.ac.ir/article-1-781-en.html
Abstract:   (56628 Views)

          Vaginitis is one of the most common genital tract infectious disease and
   the major cause of that is trichomonas vaginalis.In this prospective study,
   seven day therapeutic regimen was compared with single day therapeutic
   regimen and rate of cure and recurrence was accounted.

          606 suspected women to trichomoniasis examined with wet mount.
   Trichomonas vaginalis was seen in 76 women. Randomisely, women and
   their partner were treated with seven day metronidazole (500 mg two times
   daily) and single day metronidazole (1 gr morning and evening) regimen.
   Every group composed of 38 women. Culture and wet mount was repeated
   1 week and 1 month after treatment. Efficacy and recurrence and clinical
   cure rate of two regimens were compared.

          Two groups were not significantly different in terms of age, weight,
   education, follow up and last menstrual period. In the single day group, one
   patient missed. By use of Dorsee culture cure rate were 100% in seven day
   group and 97.3% in single day group (P=0.87). Recurrence rate were 2.6%
   and 5.4% in seven and single day regimens respectively. There were not
   significantly statistical difference between two groups (P= 0.5). Occurrence
   of side effects were not significantly different between two groups, but
   headache was observed in 21.6% and 7.9% of women in single day and
   seven day groups respectively.

          Single day regimen is recommended as an alternative therapeutic
   regimen in trichomoniasis. High efficacy, short therapeutic period and low
   cost are advantages of this regimen.

Type of Study: Original | Subject: Other Clinical Specialties

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