Lichen Planus is an inflammatory disorder of skin  and mucous
   membrane, with approximately unknown etiology and pathogenesis. From
   the clinical aspect, the disease is characterized by polygonal, purple, itchy
   and plan papules. Pathological changes are various in dermis and
   epidermis. One of those, is necrotic Keratinocyte or Civatte Body that seen
   in lower layer of epidermis and specially in upper layer of dermis.

          This investigation was a three years study of clinical and histopathological
   characteristics of Lichen Planus and relationship between response of
   Civatte body (Civ-b) and activity of the disease, in Sina hospital of
   Hamadan city (1995-98). This study was an analytic cross sectional study,
   and was performed by 106 files and microscopic slides of the patients
   affected by Lichen Planus.

          In this study, results showed that 75.8% of all dermis Civatte Body are in
   active phase of disease and this number is 88.2% for epidermis. The
   correlation between number of Civatte body and disease activity was
   statistically established by Fisher’s exact test (P value < 0.001). On the other
   hand, disease activity was also related to intensity of band from infiltration.
   Also results confirm that the more Civatte Body in dermis, the more
   epidermis Civatte Body.

          In this research, it was established that the more Civatte body, the more
   activity of Linchen planus and the decrease of Civatte Body shows
   decrease activity and relieve of disease.