Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs commonly prescribed in dental practice for the management of pain and swelling. But, rarely hypersensitivity reactions are reported.    

Case Report: A 28 year old woman underwent periodontal plastic surgery (gingival graft). Postoperative analgesics (400 mg Gelofen ,oral) and antibiotics were administrated  for the patient. Three hours after discharge of patient, she complained of  redness, itching , rapid swelling of her eyes in 10 minutes, and  watery eye discharge 1 hour after taking the drugs. She was treated with 8mg/2ml mg Dexamethasone IM at the dental department and with Hydrocortisone 100mg/ml IM and antihistamine drugs at the hospital.

Conclusion: There are no published protocols and sensitivity and specifity of skin pick testing and patch testing for Gelofen. So avoidance of re-exposure is the best management strategy. The use of Cox-2 specific medications would be a proper alternative for pain relief.