Volume 26, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2019)                   Avicenna J Clin Med 2019, 26(1): 44-50 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Basiri B, Sabzehei M K, Shokouhi Solgi M, Akbarzadeh S, Ivazeh S. Frequency and Risk Factors of Retinopathy of Prematurity in Newborns Admitted to Neonatal Intensive Care Unit in Hamadan. Avicenna J Clin Med 2019; 26 (1) :44-50
URL: http://sjh.umsha.ac.ir/article-1-1866-en.html
1- , siakbarzadeh65@yahoo.com
Abstract:   (4659 Views)
Background and Objective: Retinopathy of prematurity (ROP) is an evolutionary disorder in the retina of premature infants. Nowadays, the prevalence rate of retinopathy has increased due to the advancement of medical facilities and the increased survival of preterm infants. The aim of this study was to determine the prevalence rate of ROP and its related risk factors among infants admitted to and examined at neonatal intensive care unit (NICU) affiliated to Fatemieh Hospital in Hamadan.
Materials and Methods: This descriptive cross-sectional study was conducted on all premature infants selected with census sampling methods and with a gestational age of fewer than 34 weeks who were hospitalized in NICU for four weeks or more. The premature infants were investigated regarding the incidence of retinopathy and its risk factors.
Results: Out of 80 neonates under study, 24 (30%) cases suffered from ROP, of which 16 and 8 neonates were in stage I and II of ROP, respectively.  Moreover, the mean gestational age of newborns was 29.71±2.16 weeks, and more than 75% of ROP were observed in neonates under 29 weeks' gestational age. In addition, the results revealed that ROP correlated significantly with gestational age, low birth weight, 1st and 5th minute Apgar scores, the need to resuscitation, the use of inotropic drugs, and duration of oxygen therapy. However, there was a significant relationship between low birth weight and retinopathy based on the results obtained from logistic regression.
Conclusion: The prevalence rate of ROP stands on average regarding the results obtained from Iranian and foreign published data. Among the independent variables that affect retinopathy, low birth weight was the only significant variable affecting the incidence of retinopathy.
Full-Text [PDF 904 kb]   (1457 Downloads)    
Type of Study: Original | Subject: Pediatrics (all specialties)

1. Yau GS, Lee JW, Tam VT, Liu CC, Yip S, Cheng E, et al. Incidence and risk factors of retinopathy of prematurity from 2 neonatal intensive care units in a Hong Kong Chinese population. Asia Pac J Ophthalmol. 2016;5(3):185-91. PMID: 27183289 DOI: 10.1097/APO.0000000000000167
2. Kola M, HacioÄžLu DL, Erdol H, Turk A, Aslan Y. Determination of regional screening criteria for retinopathy of prematurity in the Eastern Black Sea region of Turkey. Turk J Med Sci. 2016;46(2):381-7. PMID: 27511500 DOI: 10.3906/sag-1410-97
3. Gibson DL, Sheps SB, Schechter MT, Wiggins S, McCormick AQ. Retinopathy of prematurity: a new epidemic? Pediatrics. 1989;83(4):486-92. PMID: 2927986
4. Augsburger JJ, Bornfeld N. Ophtalmology. St. Louis, MO: Mosby; 2004. P. 1097-102.
5. Mostafa Gharehbaghi M, Peirovifar A, Sadeghi K. Plasma leptin concentrations in preterm infants with retinopathy of prematurity (ROP). Iran J Neonatol. 2012;3(1):12-6. DOI: 10.22038/IJN.2012.275
6. Mustafa Gharebaghi M, Sadegh K, Zarghami N, Mostafizi H. Indices of vascular endothelial growth factor, leptin and insulin-like growth factor in retinopathy of prematurity. Urmia Univ Med J. 2012;23(2):91. [Persian]
7. Naderian G, Iranpour R, Mohammadizadeh M, Najafabadi FF, Badiei Z, Naseri F, et al. The frequency of retinopathy of prematurity in premature infants referred to an ophthalmology clinic in Isfahan. J Isfahan Med Sch. 2011;29(128):1-5. [Persian]
8. Nakhshab M, Ahmadzadeh Amiri A, Dargahi S, Farhadi R, Yazdani J. The incidence rate of retinopathy of prematurity and related risk factors: a study on premature neonates hospitalized in two hospitals in sari, Iran, 2014-2015. J Kerman Univ Med Sci. 2016;23(3):296-307. [Persian]
9. Mohammadi SF, Delshad H, Ghassemi F. Retinopathy of prematurity. 2nd ed. Tehran: Aftab Publication; 2014. [Persian]
10. Edy Siswanto J, Sauer PJ. Retinopathy of prematurity in Indonesia: incidence and risk factors. J Neonatal Perinat Med. 2017;10(1):85-90. PMID: 28304327 DOI: 10.3233/NPM-915142
11. Gebesce A, Uslu H, Keles E, Yildirim A, Gurler B, Yazgan H, et al. Retinopathy of prematurity: incidence, risk factors, and evaluation of screening criteria. Turk J Med Sci. 2016;46(2):315-20. PMID: 27511491 DOI: 10.3906/sag-1407-127
12. Senthil MP, Salowi MA, Bujang MA, Kueh A, Siew CM, Sumugam K, et al. Risk factors and prediction models for retinopathy of prematurity. Malays J Med Sci. 2015;22(5):57-63. PMID: 28239269
13. Fajolu IB, Rotimi-Samuel A, Aribaba OT, Musa KO, Akinsola FB, Ezeaka VC, et al. Retinopathy of prematurity and associated factors in Lagos, Nigeria. Paediatr Int Child Health. 2015;35(4):324-8. PMID: 26744157 DOI: 10.1080/20469047.2015.1109277
14. Karkhaneh R, Mousavi SZ, Riazi-Esfahani M, Ebrahimzadeh SA, Roohipoor R, Kadivar M, et al. Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran. Br J Ophthalmol. 2008;92(11):1446-9. PMID: 18728050 DOI: 10.1136/bjo.2008.145136
15. Fouladinejad M, Motahari MM, Gharib MH, Sheishari F, Soltani M. The prevalence, intensity and some risk factors of retinopathy of premature newborns in Taleghani Hospital, Gorgan, Iran. J Gorgan Univ Med Sci. 2009;11(2):51-4. [Persian]
16. Daraie G, Nooripoor S, Ashrafi AM, Ghorbani R. Incidence of retinopathy of prematurity and some related factors in premature infants born at Amir al- Momenin hospital in Semnan, Iran. Koomesh. 2016;17(2):297-303. [Persian]
17. Gerull R, Brauer V, Bassler D, Laubscher B, Pfister RE, Nelle M, et al. Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006-2015: a population-based analysis. Arch Dis Childhood Fetal Neonatal Ed. 2018;103(4):F337-42. PMID: 28916563 DOI: 10.1136/archdischild-2017-313574
18. Hwang JH, Lee EH, Kim EA. Retinopathy of prematurity among very-low-birth-weight infants in Korea: incidence, treatment, and risk factors. J Korean Med Sci. 2015;30(Suppl 1):S88-94. PMID: 26566363 DOI: 10.3346/jkms.2015.30.S1.S88
19. Thomas K, Shah PS, Canning R, Harrison A, Lee SK, Dow KE. Retinopathy of prematurity: risk factors and variability in Canadian neonatal intensive care units. J Neonatal Perinat Med. 2015;8(3):207-14. PMID: 26485554 DOI: 10.3233/NPM-15814128
20. Cerman E, Balci SY, Yenice OS, Kazokoglu H, Celiker H, Eraslan M. Screening for retinopathy of prematurity in a tertiary ophthalmology department in Turkey: incidence, outcomes, and risk factors. Ophthalmic Surg Lasers Imag Retina. 2014;45(6):550-5. PMID: 25423635 DOI: 10.3928/23258160-20141118-10
21. Chow PPC, Yip WWK, Ho M, Lok JYC, Lau HHW, Young AL. Trends in the incidence of retinopathy of prematurity over a 10-year period. Int Ophthalmol. 2019;39(4):903-9. PMID: 29907928 DOI: 10.1007/s10792-018-0896-0
22. Ahuja AA, Reddy YC, Adenuga OO, Kewlani D, Ravindran M, Ramakrishnan R. Risk factors for retinopathy of prematurity in a district in South India: a prospective cohort study. Oman J Ophthalmol. 2018;11(1):33-7. PMID: 29563692 DOI: 10.4103/ojo.OJO_97_2016
23. Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G. Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis. BMC Ophthalmol. 2018;18(1):83. PMID: 29606108 DOI: 10.1186/s12886-018-0732-3
24. Khatami SF, Yousefi A, Bayat GF, Mamuri G. Retinopathy of prematurity among 1000-2000 gram birth weight newborn infants. Iran J Pediatr. 2008;18(2):137-42.
25. Wallace DK, Kylstra JA, Phillips SJ, Hall JG. Poor postnatal weight gain: a risk factor for severe retinopathy of prematurity. J AAPOS. 2000;4(6):343-7. PMID: 11124668 DOI: 10.1067/mpa.2000.110342
26. Wu C, Lofqvist C, Smith LEH, VanderVeen DK, Hellstrom A, Consortium W. Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2012;130(8):992-9. PMID: 22491391 DOI: 10.1001/archophthalmol.2012.243
27. Binenbaum G, Ying GS, Quinn GE, Huang J, Dreiseitl S, Antigua J, et al. The CHOP postnatal weight gain, birth weight, and gestational age retinopathy of prematurity risk model. Arch Ophthalmol. 2012;130(12):1560-5. PMID: 23229697 DOI: 10.1001/archophthalmol.2012.2524
28. Hellstrom A, Engstrom E, Hard AL, Albertsson-Wikland K, Carlsson Br, Niklasson A, et al. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003;112(5):1016-20. PMID: 14595040
29. Stoltz Sjostrom E, Ãohlund I, Ahlsson F, Engstrom E, Fellman V, Hellstrom A, et al. Nutrient intakes independently affect growth in extremely preterm infants: results from a population-based study. Acta Paediatr. 2013;102(11):1067-74. PMID: 23855971 DOI: 10.1111/apa.12359
30. Dani C, Reali MF, Bertini G, Martelli E, Pezzati M, Rubaltelli FF. The role of blood transfusions and iron intake on retinopathy of prematurity. Early Hum Dev. 2001;62(1):57-63. PMID: 11245995

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb