Volume 26, Issue 3 (Avicenna Journal of Clinical Medicine-Autumn 2019)                   Avicenna J Clin Med 2019, 26(3): 158-165 | Back to browse issues page

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Akbarzadeh S, Mazdeh M, Cheraghi Z, Seyedan S M. Investigation of the Relationship between Retinal Nerve Fiber Layer Thickness and Mild Cognitive Impairment. Avicenna J Clin Med 2019; 26 (3) :158-165
URL: http://sjh.umsha.ac.ir/article-1-1942-en.html
1- Associate Professor, Department of Ophthalmology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- , mehrdokhtmazdeh@yahoo.com
Abstract:   (3184 Views)
Background and Objective: This study investigated the difference between patients with mild cognitive impairment and healthy controls using Optical Coherence Tomography (OCT) regarding Retinal Nerve Fiber Layer (RNFL) thickness.
Materials and Methods: In total, 20 patients with mild cognitive impairment and 20 healthy controls were subjected to neurological examination in this case-control study. The examinations included Minimal Mental State Examination test, comprehensive examination of the eye, and OCT using SPECTRALIS®. The data were analyzed to evaluate the thickness of RFNL through descriptive and analytical statistics. Both eyes were selected for analysis, and the patients with mild cognitive impairment were compared with the healthy controls regarding the RFNL thickness.
Results: The mean age of the patients was 61.4±3.4 years (age range: 53-65 years), and the mean RNFL thickness in patients was 100±10.1 μm. Moreover, the mean values of RNFL thickness in the lower, upper, nasal, and temporal quadrants were 128±18.9, 119±12.2, 87±14.06, and 68±10.3 μm, respectively. There was no difference between females (99±13.2) and males (103±5.6) regarding the RNFL thickness. In addition, no significant difference was observed between the male and female age groups in terms of the RNFL thickness. Additionally, there was no significant difference between the patients (100±10.1) and control group (104±8.7) regarding the RNFL thickness. The chance of developing mild cognitive impairment is increased by 1.45 times with increasing age. It should be noted that this relationship was statistically significant (P<0.001).
Conclusion: The results of this study indicate that patients with mild cognitive impairment had reduced RNFL thickness, compared to healthy controls. However, since this difference was not significant, it cannot be regarded as a proper approach for diagnosis and follow up of the patients.
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Type of Study: Original | Subject: Ophthalmology (all specialties)

1. Alzheimer’s Association. Help fight Alzheimer's. Chicago: Alzheimer’s Association; 2018.
2. Ankri J, Poupard M. Prevalence and incidence of dementia in the very elderly. Review of the literature. Rev Epidemiol Sante Publique. 2003;51(3):349-60.
3. Yokeş MB. Molecular genetics of Alzheimer's disease. J Cell Mol Biol. 2007;6(2):73-97.
4. Cogan DG. Visual disturbances with focal progressive dementing disease. Am J Ophthalmol. 1985;100(1):68-72. PMID: 3893141 DOI: 10.1016/s0002-9394(14)74985-2
5. Cronin-Golomb A, Corkin S, Growdon JH. Visual dysfunction predicts cognitive deficits in Alzheimer’s disease. Optom Vis Sci. 1995;72(3):168-76. PMID: 7609939 DOI: 10.1097/00006324-199503000-00004
6. Cummings JL. Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurological basis. Response to commentaries. Neurobiol Aging. 2000;21(6):845-61. DOI: 10.1016/S0197-4580(00)00183-4
7. Danesh-Meyer HV, Birch H, Ku JY, Carroll S, Gamble G. Reduction of optic nerve fibers in patients with Alzheimerdisease identified by laser imaging. Neurology. 2006;67(10):1852-4. PMID: 17130422 DOI:10.1212/01.wnl.0000244490.07925.8b
8. Lad EM, Mukherjee D, Stinnett SS, Cousins SW, Potter GG, Burke JR, et al. Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer’s disease. PLoS One. 2018;13(2):e0192646. PMID: 29420642 DOI: 10.1371/journal.pone.0192646
9. Ko F, Muthy ZA, Gallacher J, Sudlow C, Rees G, Yang Q, et al. Association of retinal nerve fiber layer thinning with current and future cognitive declinea: a study using optical coherence tomography. JAMA Neurol. 2018;75(10):1198-205. PMID: 29946685 DOI: 10.1001/jamaneurol.2018.1578
10. Kesler A, Vakhapova V, Korczyn AD, Naftalive E, Neudorfer M. Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Clin Neurol Neurosurg. 2011;113(7):523-6. PMID: 21454010 DOI: 10.1016/j.clineuro.2011.02.014
11. Paquet C, Boissonnot M, Roger F, Dighiero P, Gil R, Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2007;420(2):97-9. PMID: 17543991 DOI: 10.1016/j.neulet.2007.02.090
12. Sonmez I, Kosger F, Aykan U. Retinal nerve fiber layer thickness measurement by spectral-domain optical coherence tomography in patients with major depressive disorder. Noro Psikiyatr Ars. 2017;54(1):62-6. PMID: 28566961 DOI: 10.5152/npa.2015.10115
13. Budenz DL, Anderson DR, Varma R, Schuman J, Cantor L, Savell J, et al. Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT. Ophthalmology. 2007;114(6):1046-52. PMID: 17210181 DOI: 10.1016/j.ophtha.2006.08.046
14. Varma R, Bazzaz S, Lai M. Optical tomography-measured retinal nerve fiber layer thickness in normal Latinos. Invest Ophthalmol Vis Sci. 2003;44(8):3369-73. PMID: 12882783 DOI: 10.1167/iovs.02-0975
15. Mok KH, Lee VW, So KF. Retinal nerve fiber layer measurment of the Hong Kong Chinness population by optical coherence tomography. J Glaucoma. 2002;11(6):481-3.
16. Nazari M, Baladi MN, Entezari M. Comparison of the thickness of the retinal nerve fibers in normal people with multiple sclerosis patients with optic neuritis. [PhD Thesis]. Tehran: Medical School, Shahid Beheshti University of Medical Sciences and Health Services; 2013. [Persian]
17. Repka AX, Quigly HA. The effect of age on normal human optic nerve fiber layer number and diameter. Ophthalmology. 1989;96(1):26-32. PMID: 2919049 DOI: 10.1016/s0161-6420(89)32928-9

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