Volume 27, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2020)
Avicenna J Clin Med 2020, 27(1): 5-12 |
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Rabiei S, Fallah M, Jamshidi F. Comparison of Pregnancy Rate of Frozen Embryos by Two Methods: Long with GnRH Agonist and OCP with Estradiol Only. Avicenna J Clin Med 2020; 27 (1) :5-12
URL: http://sjh.umsha.ac.ir/article-1-2019-en.html
URL: http://sjh.umsha.ac.ir/article-1-2019-en.html
1- , rabiei@umsha.ac.ir
Abstract: (8370 Views)
Background & Objective: In the treatment of infertility, the management method of the luteal phase is controversial and there is no general agreement regarding the preferred protocol. The purpose of this study was to compare the pregnancy rate of frozen embryos in the Long method with the GnRH agonist and OCP with estradiol alone.
Materials and Methods: In clinical trial study a total of 128 IVF candidates were randomly assigned into two groups of 64 GnRH -OCP agonists (group A) and group receiving estradiol alone (group B). In group A, patients were treated 15 days after OCP for 12 days; GnRH agonists were also given for 14 days. In group B, estradiol valerate tablets 6 mg 2 times daily for 5 days were used for at least 10 days if normal endometrial thickness normal.
Results: The study groups were similar in mean age, duration, type and cause of infertility (P> 0.05). The mean number of eggs taken, embryos formed, embryos transferred were similar in terms of number, motility, and morphology of the spermatozoa. Laboratory and clinical pregnancies in group A were 17.2% and 15.6%, respectively, in group B were 23.4% and 20.3%, respectively (P> 0.05). The rate of abortion and multiple pregnancies were 1.6% in group A and 3.1% in group B, respectively (P> 0.05).
Conclusion: Pregnancy rate of embryos frozen in Long method with GnRH agonist and OCP with estradiol was not significantly different only in pregnancy outcome.
Materials and Methods: In clinical trial study a total of 128 IVF candidates were randomly assigned into two groups of 64 GnRH -OCP agonists (group A) and group receiving estradiol alone (group B). In group A, patients were treated 15 days after OCP for 12 days; GnRH agonists were also given for 14 days. In group B, estradiol valerate tablets 6 mg 2 times daily for 5 days were used for at least 10 days if normal endometrial thickness normal.
Results: The study groups were similar in mean age, duration, type and cause of infertility (P> 0.05). The mean number of eggs taken, embryos formed, embryos transferred were similar in terms of number, motility, and morphology of the spermatozoa. Laboratory and clinical pregnancies in group A were 17.2% and 15.6%, respectively, in group B were 23.4% and 20.3%, respectively (P> 0.05). The rate of abortion and multiple pregnancies were 1.6% in group A and 3.1% in group B, respectively (P> 0.05).
Conclusion: Pregnancy rate of embryos frozen in Long method with GnRH agonist and OCP with estradiol was not significantly different only in pregnancy outcome.
Type of Study: Original |
Subject:
Obstetrics & Gynecology
References
1. Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375(6):523-33. PMID: 27509101 DOI: 10.1056/NEJMoa1513873
2. Nananbakhsh F, Ilkhanizadeh B, Moghadasian N. Comparing the outcome of fresh and frozen embryo transfer fertility in infertile women undergoing intracytoplasmic sperm injection. Urmia Med J. 2016;27(5):402-10. [Persian]
3. Imbar T, Kol S, Lossos F, Bdolah Y, Hurwitz A, Haimov-Kochman R. Reproductive outcome of fresh or frozen-thawed embryo transfer is similar in high-risk patients for ovarian hyperstimulation syndrome using GnRH agonist for final oocyte maturation and intensive luteal support. Hum Reprod. 2012;27(3):753-9. PMID: 22252086 DOI: 10.1093/humrep/der463
4. Papageorgiou T, Guibert J, Goffinet F, Patrat C, Fulla Y, Janssens Y, et al. Percentile curves of serum estradiol levels during controlled ovarian stimulation in 905 cycles stimulated with recombinant FSH show that high estradiol is not detrimental to IVF outcome. Hum Reprod. 2002;17(11):2846-50. PMID: 12407037 DOI: 10.1093/humrep/17.11.2846
5. Forman R, Fries N, Testart J, Belaisch-Allart J, Hazout A, Frydman R. Evidence for an adverse effect of elevated serum estradiol concentrations on embryo implantation. Fertil Steril. 1988;49(1):118-22. PMID: 3335258 DOI: 10.1016/s0015-0282(16)59661-7
6. Smith EM, Anthony FW, Gadd SC, Masson GM. Trial of support treatment with human chorionic gonadotrophin in the luteal phase after treatment with buserelin and human menopausal gonadotrophin in women taking part in an in vitro fertilisation programme. BMJ. 1989;298(6686):1483-6. PMID: 2503080 DOI: 10.1136/bmj.298.6686.1483 HM. Assessment of the luteal phase in stimulatedand substituted cycles. Facts Views Vis Obgyn. 2009;1(1):30-46. PMID: 25478069
7. Niu Z, Chen Q, Sun Y, Feng Y. Long-term pituitary down-regulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis. Gynecol Endocrinol. 2013;29(12):1026-30. PMID: 24006906 DOI: 10.3109/09513590.2013.824960
8. Hebisha SA, Adel HM. GnRH agonist treatment improves implantation and pregnancy rates of frozen-thawed embryos transfer. J Obstet Gynaecol India. 2017;67(2):133-6. PMID: 28405121 DOI: 10.1007/s13224-016-0936-5
9. Sharara FI, McClamrock HD. Ratio of oestradiol concentration on the day of human chorionic gonadotrophin administration to mid-luteal oestradiol concentration is predictive of in-vitro fertilization outcome. Hum Reprod. 1999;14(11):2777-82. PMID: 10548621 DOI: 10.1093/humrep/14.11.2777
10. Gizzo S, Andrisani A, Esposito F, Noventa M, Di Gangi S, Angioni S, et al. Which luteal phase support is better for each IVF stimulation protocol to achieve the highest pregnancy rate? A superiority randomized clinical trial. Gynecol Endocrinol. 2014;30(12):902-8 PMID: 25268567 DOI: 10.3109/09513590.2014.964638
11. Mijatovic V, Florijn E, Halim N, Schats R, Hompes P. Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. Eur J Obstet Gynecol Reprod Biol. 2010;151(1):62-5. PMID: 20409633 DOI: 10.1016/j.ejogrb.2010.02.047
12. Aflatoonian A, Mansoori-Torshizi M, Farid Mojtahedi M, Aflatoonian B, Khalili MA, Amir-Arjmand MH, et al. Fresh versus frozen embryo transfer after gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone antagonist cycles among high responder women: A randomized, multi-center study. Int J Reprod Biomed (Yazd). 2018;16(1):9-18. PMID: 29675483
13. Tsai HW, Wang PH, Lin LT, Chen SN, Tsui KH. Using gonadotropin-releasing hormone agonist before frozen embryo transfer may improve ongoing pregnancy rates in hyperandrogenic polycystic ovary syndrome women. Gynecol Endocrinol. 2017;33(9):686-9. PMID: 28393637 DOI: 10.1080/09513590.2017.1307961
14. Wang R, Lin S, Wang Y, Qian W, Zhou L. Comparisons of GnRH antagonist protocol versus GnRH agonist long protocol in patients with normal ovarian reserve: a systematic review and meta-analysis. PLoS One. 2017;12(4):e0175985. PMID: 28437434 DOI: 10.1371/journal.pone.0175985
15. Sefrioui O, Madkour A, Kaarouch I, Louanjli N. Luteal estradiol pretreatment of poor and normal responders during GnRH antagonist protocol. Gynecol Endocrinol. 2019;35(12):1067-71. PMID: 31142165 DOI: 10.1080/09513590.2019.1622086
16. Khadem Ghaebi N, Mahmoudiniya M, Najaf Najafi M, Zohdi E, Attaran M. Comparison of letrozole with gonadotropin-releasing hormone agonist in frozen embryo transfer after recurrent implantation failure: an RCT. Int J Reprod Biomed (Yazd). 2020;18(2):105-12. PMID: 32259004 DOI: 10.18502/ijrm.v18i2.6417
17. Wong KM, Mastenbroek S, Repping S. Cryopreservation of human embryos and its contribution to in vitro fertilization success rates. Fertil Steril. 2014;102(1):19-26. PMID: 24890275 DOI: 10.1016/j.fertnstert.2014.05.027
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