Volume 30, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2023)
Avicenna J Clin Med 2023, 30(1): 30-37 |
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Khazaei M, Kulivand S, Hashemi S H, Soltanian A, Kahramfar Z, Nadi E. Comparison of Lung CT Scan Findings upon Admission and Three Months after the Discharge of Patients with COVID-19. Avicenna J Clin Med 2023; 30 (1) :30-37
URL: http://sjh.umsha.ac.ir/article-1-2657-en.html
URL: http://sjh.umsha.ac.ir/article-1-2657-en.html
Milad Khazaei1 
, Sohrab Kulivand2 , Seyed Hamid Hashemi3 , Alireza Soltanian4 , Zohreh Kahramfar1 , Ebrahim Nadi 5
, Sohrab Kulivand2 , Seyed Hamid Hashemi3 , Alireza Soltanian4 , Zohreh Kahramfar1 , Ebrahim Nadi 5
1- Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Infectious Diseases, School of Medicine, Infectious Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4- Depatment of Biostatistics, School of Health, Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , nadi@umsha.ac.ir
2- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Infectious Diseases, School of Medicine, Infectious Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4- Depatment of Biostatistics, School of Health, Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , nadi@umsha.ac.ir
Abstract: (602 Views)
Background and Objective: There is not enough information about the long-term pulmonary complications of patients with COVID-19. This prospective study aimed to compare the findings of lung CT scan upon admission and three months after the discharge of patients with COVID-19.
Materials and Methods: This prospective study was conducted on 60 patients with COVID-19 hospitalized in Shahid Beheshti and Sina hospitals in Hamadan, Iran, in 2020-2021. The lung CT scan results of the patients upon admission and three months later were assessed and compared by an experienced radiologist quantitatively and qualitatively after obtaining and recording the demographic characteristics, risk factors, and clinical findings.
Results: The mean score of lung involvement upon hospitalization of the patients was 3.7±1.4, and three months after discharge, it was determined at 1.1±1.2. The most frequent findings in the initial CT scan of the patients were ground-glass opacification, mixed GGO, and bands with frequencies of 60%, 36.7%, and 18.3%, respectively. After three months, CT scan results of 32 (53.3%) patients showed lung involvement and an abnormal finding in the lung, the most common of which were ground-glass opacification, mixed GGO, and bands with frequencies of 30%, 13.3%, and 10.0%, respectively. Patients who had pulmonary involvement three months after discharge had a higher average lung involvement score during hospitalization (4.4±1.5 vs. 2.9±0.7, P=0.001).
Conclusion: Abnormal CT scan results of the lung three months after discharge is common in COVID-19 patients, among whom patients with more pulmonary involvement during hospitalization have more abnormal findings
Materials and Methods: This prospective study was conducted on 60 patients with COVID-19 hospitalized in Shahid Beheshti and Sina hospitals in Hamadan, Iran, in 2020-2021. The lung CT scan results of the patients upon admission and three months later were assessed and compared by an experienced radiologist quantitatively and qualitatively after obtaining and recording the demographic characteristics, risk factors, and clinical findings.
Results: The mean score of lung involvement upon hospitalization of the patients was 3.7±1.4, and three months after discharge, it was determined at 1.1±1.2. The most frequent findings in the initial CT scan of the patients were ground-glass opacification, mixed GGO, and bands with frequencies of 60%, 36.7%, and 18.3%, respectively. After three months, CT scan results of 32 (53.3%) patients showed lung involvement and an abnormal finding in the lung, the most common of which were ground-glass opacification, mixed GGO, and bands with frequencies of 30%, 13.3%, and 10.0%, respectively. Patients who had pulmonary involvement three months after discharge had a higher average lung involvement score during hospitalization (4.4±1.5 vs. 2.9±0.7, P=0.001).
Conclusion: Abnormal CT scan results of the lung three months after discharge is common in COVID-19 patients, among whom patients with more pulmonary involvement during hospitalization have more abnormal findings
Type of Study: Original |
Subject:
Lung Diseases
Extended Abstract [HTML 24 KB] (47 Download)
References
1. Dhar J, Samanta J, Kochhar R. Corona Virus Disease-19 pandemic: The gastroenterologists' perspective. Indian J Gastroenterol. 2020;39(3):220-31. PMID: 32783168 DOI: 10.1007/s12664-020-01075-2
2. Guo J, Ge J, Guo Y. Recent advances in methods for the diagnosis of Corona Virus Disease 2019. J Clin Lab Anal. 2022;36(1):e24178. PMID: 34921443 DOI: 10.1002/jcla.24178
3. V'Kovski P, Kratzel A, Steiner S, Stalder H, Thiel V. Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol. 2021;19(3):155-70. PMID: 33116300 DOI: 10.1038/s41579-020-00468-6
4. Fang Y,Zhang H, Xie J, Lin MYing L, Pang PJi W. Sensitivity of chest CT for COVID-19:Comparison to RT-PCR. Radiology. 2020;296(2):115-7. PMID: 32073353 DOI: 10.1148/radiol.2020200432
5. Hu B, Guo H, Zhou P, Shi ZL. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021;19(3):141-54. PMID: 33024307 DOI: 10.1038/s41579-020-00459-7
6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. DOI: 10.1001/jama.2020.2648
7. Böger B, Fachi MM, Vilhena RO, Cobre AF, Tonin FS, Pontarolo R. Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19. Am J Infect Control. 2021;49(1):21-9. PMID: 32659413 DOI: 10.1016/j.ajic.2020.07.011
8. Dramé M, Tabue Teguo M, Proye E, Hequet F, Hentzien M, Kanagaratnam L, et al. Should RT-PCR be considered a gold standard in the diagnosis of COVID-19? J Med Virol. 2020;92(11):2312-3. PMID: 32383182 DOI: 10.1002/jmv.25996
9. Yamayoshi S, Sakai-Tagawa Y, Koga M, Akasaka O, Nakachi I, Koh H, et al. Comparison of rapid antigen tests for COVID-19. Viruses. 2020;12(12):1420. PMID: 33322035 DOI: 10.3390/v12121420
10. Chams N, Chams S, Badran R, Shams A, Araji A, Raad M, et al. COVID-19: A Multidisciplinary Review. Front Public Health. 2020;8:383. PMID: 32850602 DOI: 10.3389/fpubh.2020.00383
11. Rehman SU, Rehman SU, Yoo HH. COVID-19 challenges and its therapeutics. Biomed Pharmacother. 2021;142:112015. PMID: 34388532 DOI: 10.1016/j.biopha.2021.112015
12. Xiong Y, Sun D, Liu Y, Fan Y, Zhao L, Li X, et al. Clinical and high-resolution CT features of the COVID-19 infection: comparison of the initial and follow-up changes. Invest Radiol. 2020;55(6):332-9. PMID: 32134800 DOI: 10.1097/RLI.0000000000000674
13. González J, Benítez ID, Carmona P, Santisteve S, Monge A, Moncusí-Moix A, et al. Pulmonary function and radiologic features in survivors of critical COVID-19: A 3-month prospective cohort. Chest. 2021;160(1):187-98. PMID: 33676998 DOI: 10.1016/j.chest.2021.02.062
14. Vijayakumar B, Tonkin J, Devaraj A, Philip KEJ, Orton CM, Desai SR, et al. CT lung abnormalities after COVID-19 at 3 months and 1 year after hospital discharge. Radiology. 2022;303(2):444-54. PMID: 34609195 DOI: 10.1148/radiol.2021211746
15. Liang T, Liu Z, Wu CC, Jin C, Zhao H, Wang Y, et al. Evolution of CT findings in patients with mild COVID-19 pneumonia. Eur Radiol. 2020;30(9):4865-73. PMID: 32291502 DOI: 10.1007/s00330-020-06823-8
16. Mandal S, Barnett J, Brill SE, Brown JS, Denneny EK, Hare SS, et al. 'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax. 2021;76(4):396-8. PMID: 33172844 DOI: 10.1136/thoraxjnl-2020-215818
17. Shah AS, Wong AW, Hague CJ, Murphy DT, Johnston JC, Ryerson CJ, et al. A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations. Thorax. 2021;76(4):402-4. PMID: 33273023 DOI: 10.1136/thoraxjnl-2020-216308
18. Wu X, Dong D, Ma D. Thin-section computed tomography manifestations during convalescence and long-term follow-up of patients with severe acute respiratory syndrome (SARS). Med Sci Monit. 2016;22:2793-9. PMID: 27501327 DOI: 10.12659/msm.896985
19. Ahmed H, Patel K, Greenwood DC, Halpin S, Lewthwaite P, Salawu A, et al. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis. J Rehabil Med. 2020;52(5):jrm00063. PMID: 32449782 DOI: 10.2340/16501977-2694
20. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):18. PMID: 30872586 DOI: 10.1038/s41572-019-0069-0
21. Lerum TV, Aaløkken TM, Brønstad E, Aarli B, Ikdahl E, Lund KMA, et al. Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19. Eur Respir J. 2021;57(4):2003448. PMID: 33303540 DOI: 10.1183/13993003.03448-2020
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