Volume 32, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2026)
Avicenna J Clin Med 2026, 32(4): 209-217 |
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Ahmadzadeh A, Mohammadjafari R, Saadati N, Sabzi Pilevari N. Histopathology and Colposcopy Findings in Patients with Low-Risk Human Papillomavirus (HPV) Types. Avicenna J Clin Med 2026; 32 (4) :209-217
URL: http://sjh.umsha.ac.ir/article-1-3289-en.html
URL: http://sjh.umsha.ac.ir/article-1-3289-en.html
1- Department of Obstetrics & Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Obstetrics & Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,dr.nasim.sp@gmail.com
2- Department of Obstetrics & Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
Abstract: (36 Views)
Background and Objective: Although infection with low-risk Human Papillomavirus (HPV) types is generally associated with a low risk of malignancy, clinical data on the colposcopy and histopathological features of these patients in specialized centers remain limited. This study was designed to systematically examine these findings in patients with low-risk HPV types referred to an oncology clinic.
Materials and Methods: This retrospective cross-sectional study was conducted on the medical records of 150 patients with low-risk HPV types who were referred to the oncology clinic of Imam Khomeini Hospital in Ahvaz between 2020 and 2023. Demographic, clinical, colposcopy, cytological, and histopathological data were collected. Data analysis was performed using the independent t-test for comparing means and the chi-square test for assessing associations between qualitative variables.
Results: The mean age of the patients was 34.03 years. Histopathologically, 94% of patients had benign results, while only 6% were diagnosed with Cervical Intraepithelial Neoplasia (CIN1). Colposcopy findings showed non-specific lesions in 40 %, normal results in 32%, and low-grade lesions in 28 %. Among the factors studied, colposcopy findings had the strongest association with a diagnosis of CIN1 (P=0.015); specifically, 66.67% of patients in the CIN1 group had "Low Grade" findings, whereas this rate was only 25.53% in the normal group. Infection with HPV type 55 showed a significant association with an increased risk of CIN1 (P=0.044). None of the other demographic or clinical variables showed a statistically significant association with the histopathological outcome.
Conclusion: The findings confirm that infection with low-risk HPV types rarely leads to premalignant lesions, and most cases have a benign outcome. However, it is essential to pay attention to specific genotypes such as HPV-55, which may increase the risk of CIN1.
Materials and Methods: This retrospective cross-sectional study was conducted on the medical records of 150 patients with low-risk HPV types who were referred to the oncology clinic of Imam Khomeini Hospital in Ahvaz between 2020 and 2023. Demographic, clinical, colposcopy, cytological, and histopathological data were collected. Data analysis was performed using the independent t-test for comparing means and the chi-square test for assessing associations between qualitative variables.
Results: The mean age of the patients was 34.03 years. Histopathologically, 94% of patients had benign results, while only 6% were diagnosed with Cervical Intraepithelial Neoplasia (CIN1). Colposcopy findings showed non-specific lesions in 40 %, normal results in 32%, and low-grade lesions in 28 %. Among the factors studied, colposcopy findings had the strongest association with a diagnosis of CIN1 (P=0.015); specifically, 66.67% of patients in the CIN1 group had "Low Grade" findings, whereas this rate was only 25.53% in the normal group. Infection with HPV type 55 showed a significant association with an increased risk of CIN1 (P=0.044). None of the other demographic or clinical variables showed a statistically significant association with the histopathological outcome.
Conclusion: The findings confirm that infection with low-risk HPV types rarely leads to premalignant lesions, and most cases have a benign outcome. However, it is essential to pay attention to specific genotypes such as HPV-55, which may increase the risk of CIN1.
Type of Study: Original |
Subject:
Obstetrics & Gynecology
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